A Method to Identify and Analyze Biological Programs through Automated Reasoning [0.03%]
一种通过自动推理鉴定和分析生物程序的方法
Boyan Yordanov,Sara-Jane Dunn,Hillel Kugler et al.
Boyan Yordanov et al.
Predictive biology is elusive because rigorous, data-constrained, mechanistic models of complex biological systems are difficult to derive and validate. Current approaches tend to construct and examine static interaction network models, whi...
Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire [0.03%]
通过自动枚举和分析表型谱系来阐明基因型-表型映射关系
Jason G Lomnitz,Michael A Savageau
Jason G Lomnitz
Background: The gap between genotype and phenotype is filled by complex biochemical systems most of which are poorly understood. Because these systems are complex, it is widely appreciated that quantitative understanding ...
Emergence of multiple collective motility modes in a physical model of cell chains [0.03%]
细胞链物理模型中多种集体运动模式的产生
Collective cell migration is central to processes like development and cancer metastasis. While mechanisms of collective motility are increasingly understood, their classification remains incomplete. Here, we study the migration of small ce...
Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer's disease [0.03%]
外周血疾病转化模型鉴定出可预测阿尔茨海默病的2型糖尿病生物标志物
Type 2 diabetes (T2D) is a significant risk factor for Alzheimer's disease (AD). Despite multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is poorly understood. It is challenging to design studies that ad...