Spatiotemporal instability of influenza seasonality during viral co-circulation [0.03%]
病毒共循环期间流感季节性时空不稳定性研究
Hong Liu,Xuanfeng Li,Ning Sun et al.
Hong Liu et al.
Co-circulation of multiple influenza subtypes poses a major challenge to global public health. However, its specific impact on non-stationary epidemic sequences and coupling relationships with environmental drivers remains poorly understood...
Learning patient-specific spatial biomarker dynamics via operator learning for Alzheimer's disease progression [0.03%]
基于算子学习的阿尔茨海默病进展过程中的个体特异性空间生物标志物动力学研究
Jindong Wang,Yutong Mao,Xiao Liu et al.
Jindong Wang et al.
Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder with substantial heterogeneity in progression and treatment response. Despite recent therapeutic advances, predictive models capable of accurately forecasting ...
Genetic basis of temporal variation in phenology in a woody perennial plant [0.03%]
木质多年生植物物候时间变化的遗传基础
Yang Liu
Yang Liu
The form of phenotypic plasticity in traits that are repeatedly and potentially reversibly expressed multiple times throughout an individual's lifetime is labile plasticity. Yet, little is known about selection on, and genetic variation and...
Design principles for robust multistability in coupled feedforward-feedback regulatory circuits [0.03%]
兼备前馈-反馈调控回路的稳健多稳态设计原理
Hong Qi,Zhi-Yu Zhao,Yu-Song Yin et al.
Hong Qi et al.
Feedforward loops (FFLs) and feedback loops (FBLs) are ubiquitous network motifs that mediate signal filtering, pulse generation, and state switching; yet, how coupling FBLs to FFLs produces robust multistability-a key mechanism for cellula...
Karoline Horgmo Jæger,Aslak Tveito
Karoline Horgmo Jæger
Excitable cells are commonly studied via the extracellular potentials (EPs) they generate, which underlie signals in electroencephalography (EEG), electrocardiography (ECG), and multielectrode array (MEA) recordings. However, some excitable...
Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia [0.03%]
关联感觉时空层次和功能梯度正则化递归神经网络在精神分裂症中的应用
Subati Abulikemu,Puria Radmard,Michail Mamalakis et al.
Subati Abulikemu et al.
The human neocortex is functionally organised at its highest level along a continuous sensory-to-association (AS) hierarchy. This study investigates two questions-how this hierarchy is structurally altered in schizophrenia, and what these a...
Single-trajectory Bayesian modeling reveals multi-state diffusion of the MSH sliding clamp [0.03%]
基于单轨迹的贝叶斯模型揭示MSH滑动夹具的多态扩散特性
Seongyu Park,Inho Yang,Jinseob Lee et al.
Seongyu Park et al.
DNA mismatch repair (MMR) is an essential mechanism for preserving genomic integrity across diverse living organisms. In this process, MutS homologs (MSH) play crucial roles in detecting mismatched basepairs and recruiting downstream MMR pr...
Leona M Irwin,Shaun M Cowley,Himanshu Kaul
Leona M Irwin
Human gastrulation remains a black box due to ethical and technical reasons. Human pluripotent stem cell-based 2D micropatterns and 3D organoids (gastruloids) recapitulate aspects of human gastrulation. Understanding the integrated multisca...
Rewiring miR-22/SNAI1 via CRISPR-based edge editing destabilizes the epithelial phenotype [0.03%]
通过CRISPR边缘编辑改变miR-22/SNAI1的相互作用使上皮表型不稳态
John T Nguyen,Lijia Huang,Herbert Levine et al.
John T Nguyen et al.
Epithelial-to-Mesenchymal Transition (EMT) is a critical biological process by which cells acquire enhanced migratory and invasive properties. A key signaling pathway involved in EMT phenotypes includes transforming growth factor β (TGFβ)...