Multidimensional trophoblast invasion assessment by combining 3D in vitro modeling and deep learning analysis [0.03%]
结合体外三维模型和深度学习分析的多维度滋养层侵袭评估方法
Ayberk Alp Gyunesh,Marlene Rezk-Füreder,Celine Kapper et al.
Ayberk Alp Gyunesh et al.
Infertility affects millions of couples worldwide, and in vitro fertilization is a key therapeutic strategy for achieving parenthood. Despite advances, the first IVF attempt fails in ~60% of patients, highlighting the need for innovative so...
Predicting treatment-free remission in chronic myeloid leukemia patients using an integrated model of tumor-immune dynamics [0.03%]
基于肿瘤免疫动力学综合模型预测慢性髓系白血病患者的治疗-free缓解期
Artur C Fassoni,Agnes S M Yong,Richard E Clark et al.
Artur C Fassoni et al.
The interactions between tumor and the immune system are main factors in determining cancer treatment outcomes. In Chronic Myeloid Leukemia (CML), considerable evidence shows that the dynamics between residual leukemia and the patient's imm...
María Moscardó García,Atte Aalto,Arthur N Montanari et al.
María Moscardó García et al.
Biological phenotypes emerge from complex interactions across molecular layers. Yet, data-driven approaches to infer these regulatory networks have primarily focused on single-omic studies, overlooking inter-layer regulatory relationships. ...
Systems modeling and uncertainty quantification of AMP-activated protein kinase signaling [0.03%]
AMP活化蛋白激酶信号转导的系统建模及不确定性量化
Nathaniel Linden-Santangeli,Jin Zhang,Boris Kramer et al.
Nathaniel Linden-Santangeli et al.
AMP-activated protein kinase (AMPK) plays a key role in restoring cellular metabolic homeostasis after energy stress. Importantly, AMPK acts as a hub of metabolic signaling, integrating multiple inputs and acting on numerous downstream targ...
An integrative molecular systems approach unravels mechanisms underlying biphasic nitrate uptake by plant nitrate transporter NRT1.1 [0.03%]
整合型分子系统方法解析植物双相硝酸盐摄取的机理
Seemadri Subhadarshini,Sarthak Sahoo,Mohit Kumar Jolly et al.
Seemadri Subhadarshini et al.
Elucidating the mechanisms of transport kinetics in plants is crucial to develop crops that can use nutrients efficiently. The plant nitrate transporter NRT1.1 rapidly switches between high- and low-affinity transport modes to maintain an o...
Constraint based modeling of drug induced metabolic changes in a cancer cell line [0.03%]
基于约束的癌症细胞系药物诱导的代谢变化建模研究
Xavier Benedicto,Åsmund Flobak,Miguel Ponce-de-Leon et al.
Xavier Benedicto et al.
Cancer cells frequently reprogramme their metabolism to support growth and survival, making metabolic pathways attractive targets for therapy. In this study, we investigated the metabolic effects of three kinase inhibitors and their synergi...
Hossein Akbarialiabad,Amirmohammad Pasdar,Dédée F Murrell et al.
Hossein Akbarialiabad et al.
Digital twins (DTs) can transform randomized clinical trials by improving ethical standards, including safety, informed consent, equity, and data privacy. They also enhance trial efficiency by enabling early detection of adverse events and ...
Minimal gene signatures enable high-accuracy prediction of antibiotic resistance in Pseudomonas aeruginosa [0.03%]
最小的基因标记可以实现对铜绿假单胞菌抗生素抗性的高精度预测
Nabia Shahreen,Syed Ahsan Shahid,Mahfuze Subhani et al.
Nabia Shahreen et al.
Antimicrobial resistance (AMR) in Pseudomonas aeruginosa poses a critical global health challenge, with current diagnostics relying on slow, culture-based methods. Here, we present a ML framework leveraging transcriptomic data to predict an...
Machine learning framework to extract physicochemical features of B-cell epitopes recognized by a cross-reactive antibody [0.03%]
机器学习框架提取B细胞表位的理化特征以识别交叉反应性抗体
Simranjit Grewal,Uwa Iyamu,Daniel Ferrer Vinals et al.
Simranjit Grewal et al.
During infection with Plasmodium falciparum in pregnancy, parasites express a unique virulence factor, VAR2CSA, that mediates binding of infected red blood cells to the placenta. A major goal in designing vaccines to protect pregnant women ...
Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback [0.03%]
拟南芥根表皮细胞型式由基因调控网络和扩散动力学反馈产生
Aarón Castillo-Jiménez,Adriana Garay-Arroyo,María de La Paz Sánchez et al.
Aarón Castillo-Jiménez et al.
We propose a system biology approach to understand how GRNs' dynamical feedback with diffusion of some molecular components underlie the emergence of spatial cellular patterns. We use experimental data on the GRN underlying cell differentia...