Integrated multi-omics and single-cell analysis reveals CDKN2A-mediated cuproptosis mechanisms driving thyroid carcinoma progression [0.03%]
整合多组学和单细胞分析揭示了CDKN2A介导的铜死亡机制驱动甲状腺癌进展
Jukai Huang,Liping Wang
Jukai Huang
Cuproptosis is a recently identified copper-dependent cell death pathway with growing relevance in tumor biology, yet its involvement in thyroid carcinoma (TC) remains poorly understood. In this study, we integrated multi-omics datasets to ...
Neuronal and glial networks interact with traumatic brain injury to modulate cognition in ABCD study [0.03%]
ABCD研究中神经元和胶质网络与创伤性脑损伤相互作用以调节认知功能
Michael Cheng,Melody Mao,Wenjing Meng et al.
Michael Cheng et al.
Mild traumatic brain injury (mTBI) disproportionately affects children and adolescents and has been associated with poorer neurocognitive performance, but the biological mechanisms driving symptom variability and severity remain understudie...
Simone Bruno,Domitilla Del Vecchio
Simone Bruno
Here, we review mathematical models of epigenetic memory, focusing on chromatin modifications as key mechanisms to achieve long-term maintenance of epigenetic states. After reviewing the main stochastic modeling frameworks, we focus on stoc...
The p21 resilience network: a conceptual framework linking senescence to ferroptosis and cuproptosis resistance [0.03%]
p21耐逆境网络：一个连接衰老、铁死亡和铜死亡抗性的概念框架
Shantanu Gupta
Shantanu Gupta
We reconceptualize p21 as the master regulator of a "resilience network" that empowers cancer cells to defy therapy. Beyond cell cycle arrest, p21 orchestrates a multi-faceted defense, suppressing ferroptosis and cuproptosis by governing re...
Mathematical modeling of planar cell polarity: principles, approaches, and open questions [0.03%]
平面细胞极性的数学建模：原则、方法及悬而未决的问题
Mohd Suhail Rizvi,Mohit Kumar Jolly
Mohd Suhail Rizvi
Planar cell polarity represents a fundamental mechanism by which cells within epithelial sheets align their orientation, enabling coordinated tissue morphogenesis and function. Disruption of PCP leads to developmental defects and disease, h...
Publisher Correction: Rethinking medical education through systems biology to address complexity [0.03%]
出版更正：通过系统生物学重新考虑医学教育以解决复杂性问题
Laurent David,Pierre-Antoine Gourraud,Guillaume Lamirault et al.
Laurent David et al.
Published Erratum
NPJ systems biology and applications. 2026 Mar 6;12(1):33. DOI:10.1038/s41540-026-00672-9 2026
Neuro-Dynamic Quantitative Systems Pharmacology (QSP) model describing Alzheimer's disease pathophysiology and treatment effects [0.03%]
描述阿尔茨海默病病理生理学和治疗作用的神经动力定量系统药理学（QSP）模型
Youfang Cao,Brian A Willis,Kanta Horie et al.
Youfang Cao et al.
Lecanemab, an anti-amyloid antibody, has demonstrated a significant clinical benefit in slowing cognitive decline in early Alzheimer's disease (AD). A mechanistic Neuro-Dynamic Quantitative Systems Pharmacology (QSP) model was developed to ...
Cancer-associated fibroblasts drive metabolic heterogeneity in colorectal cancer cells: predictions from metabolic modeling [0.03%]
癌症相关成纤维细胞驱动结直肠癌细胞代谢异质性：来自代谢模型的预测
Elizabeth Elton,Niki Tavakoli,Handan Cetin et al.
Elizabeth Elton et al.
KRAS-mutant colorectal cancer (CRC) undergoes metabolic reprogramming that promotes tumor progression and drug resistance. Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play a pivotal role in m...
Experimentally calibrated multiscale model predicts schedule dependent drug combination effects [0.03%]
实验校准的多尺度模型预测时间依赖性的药物组合效应
Othmane Hayoun-Mya,Arnau Montagud,Alfonso Valencia et al.
Othmane Hayoun-Mya et al.
Therapeutic synergy emerges from interactions between molecular drug action, intracellular signaling, and tissue-level transport dynamics. We developed a multiscale model integrating these scales to predict schedule-dependent drug combinati...
Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation [0.03%]
瘦素缺乏型肥胖小鼠在饥饿状态下的代谢反应能力的全面下降及酶活性升高
Dongzi Li,Keigo Morita,Toshiya Kokaji et al.
Dongzi Li et al.
Starvation induces complex metabolic adaptations in skeletal muscle, a key tissue for maintaining energy homeostasis; however, these adaptations are largely impaired in obesity. How obesity alters global metabolic adaptations to starvation ...