Daniel Ramirez,David A Kessler,Mingyang Lu et al.
Daniel Ramirez et al.
The Epithelial-mesenchymal transition (EMT) is a cellular state transition fundamental to development, wound healing, and cancer metastasis. The gene regulatory mechanisms underlying EMT have been extensively documented, revealing gene regu...
Digital dementia and testing of cognitive intervention for degenerating neural networks [0.03%]
数字化痴呆及退化型神经网络的认知干预测试方法研究
Jasmine A Moore,Vibujithan Vigneshwaran,Anthony J Winder et al.
Jasmine A Moore et al.
The development of effective interventions for neurodegenerative disorders, such as posterior cortical atrophy (a visual Alzheimer's variant), remains to be a significant clinical challenge. We introduce a computational framework using conv...
Author Correction: Enhancing randomized clinical trials with digital twins [0.03%]
作者勘误：用数字孪生技术增强随机临床试验
Hossein Akbarialiabad,Amirmohammad Pasdar,Dédée F Murrell et al.
Hossein Akbarialiabad et al.
Published Erratum
NPJ systems biology and applications. 2025 Nov 6;11(1):124. DOI:10.1038/s41540-025-00609-8 2025
Modeling tumor dynamics and predicting response to therapies in a murine pancreatic cancer model [0.03%]
一种小鼠胰腺癌模型的肿瘤动态建模及预测对各种疗法的反应
Krithik Vishwanath,Hoon Choi,Mamta Gupta et al.
Krithik Vishwanath et al.
We seek to establish a parsimonious mathematical framework for understanding the interaction and dynamics of the response of pancreatic cancer to the NGC triple chemotherapy regimen (mNab-paclitaxel, gemcitabine, and cisplatin), stromal-tar...
Flexible modulation of hybrid feedback loops in competitive biological oscillators [0.03%]
竞争性生物振荡器中混合反馈回路的灵活调控
Peng Zhao,Jian Liu,Tengfei Bao et al.
Peng Zhao et al.
Biological oscillators control vital rhythmic processes, and their dysregulation is associated with disorders such as cancer, sleep disturbances, and motor deficits. These oscillators often exhibit competitive interactions through mutual in...
Alternative Promoters Drive Transcriptomic Reprogramming and Prognostic Stratification in TNBC [0.03%]
替代启动子驱动的三阴性乳腺癌转录组重塑及预后分层
Simran Jit,Kirti Jain,Leepakshi Dhingra et al.
Simran Jit et al.
Pre-transcriptional regulation through alternative promoter usage is a critical yet underexplored mechanism influencing gene expression in Triple-Negative Breast Cancer (TNBC), a highly aggressive and heterogeneous breast cancer subtype. Wh...
MMP9 shapes cell mechanics to enable collective invasion in cancer [0.03%]
基质金属蛋白酶MMP9通过重塑肿瘤细胞机械性能促进集体侵袭
Asadullah,Sarbajeet Dutta,Sumon Kumar Saha et al.
Asadullah et al.
Cooperation among phenotypically distinct sub-populations within a tumor plays a key role in cancer progression. In this study, we investigated how proteolytic heterogeneity supports collective cancer invasion. In invasive MDA-MB-231 breast...
ROS-induced voltage-gated ion channel expression and electrophysiological remodeling in malignant human cells [0.03%]
ROS诱导的电压门控离子通道在恶性人类细胞中的表达及电生理重构
Mohammad Mohammadiaria
Mohammad Mohammadiaria
Environmental stressors such as radiation, pH shifts, temperature variations, and electromagnetic fields can trigger intracellular oxidative stress, upregulating voltage-gated ion channel (VGIC) gene expression. This paper presents a hybrid...
A constraint-based framework for exploring the impact of multireaction dependencies on metabolic functions [0.03%]
基于约束的探索多反应依赖性对代谢功能影响的框架
Anika Küken,Damoun Langary,Angela Angeleska et al.
Anika Küken et al.
Metabolism operates under physico-chemical constraints that result in multireaction dependencies. Understanding how multireaction dependencies affect metabolic phenotypes remains challenging, hindering their biotechnological applications. H...
JNK activation dynamics drive distinct gene expression patterns over time mediated by mRNA stability [0.03%]
JNK激活动力学通过mRNA稳定性在不同时段驱动不同的基因表达模式
Abbas Jedariforoughi,Rachel Burke,Andrew Chesak et al.
Abbas Jedariforoughi et al.
c-Jun N-terminal kinase (JNK) plays a major role in the regulation of cell death. Numerous studies have highlighted how the dynamics of this kinase dictate whether cells survive in response to cellular stress or induce cell death mechanisms...