From FAIR to CURE: guidelines for computational models of biological systems [0.03%]
从FAIR到CURE：生物系统计算模型的指导原则
Herbert M Sauro,Eran Agmon,Michael L Blinov et al.
Herbert M Sauro et al.
Guidelines for managing scientific data have been established under the FAIR principles, requiring that data be Findable, Accessible, Interoperable, and Reusable. In many scientific disciplines, especially computational biology, both data a...
Metabolic gene expression-based stratification and prognostic risk predictive model of head and neck squamous cell carcinoma [0.03%]
基于代谢基因表达的头颈部鳞状细胞癌分层及预后风险预测模型
Soumya Sau,Anjali Gupta,Swastik Sinha et al.
Soumya Sau et al.
Head and neck squamous cell carcinoma (HNSCC) is a complex multivariable disease posing a significant challenge in therapeutics. OXPHOS and PPP are centrally implicated in metabolic heterogeneity influencing tumor behavior, treatment respon...
Multi-omics integration reveals ANXA6-high γδ T cell-endothelial communication as a potential link between periodontitis and MASLD [0.03%]
多组学整合揭示ANXA6高表达的γδT细胞-内皮细胞通讯可能是牙周炎和MASLD联系的关键因素
Zhongxuan Zhang,Zihan Ma,Ruidong Zhang et al.
Zhongxuan Zhang et al.
Periodontitis (PD) and metabolic dysfunction-associated steatotic liver disease (MASLD) were highly prevalent inflammatory disorders that frequently coexisted, yet the molecular basis of their comorbidity remained poorly defined. Here, we a...
Improving severity grading of chemotherapy-induced myelosuppression in AML via data-driven and model-based deep learning [0.03%]
基于数据驱动和模型驱动的深度学习改进化疗引起的急性髓系白血病髓抑制分级
Yu Zhou,Yuyang Xiao,Qian Wang et al.
Yu Zhou et al.
Chemotherapy-induced myelosuppression in acute myeloid leukemia (AML) frequently leads to life-threatening complications, yet current assessment standards lack the specificity required for personalized risk prediction. We present MM-AI-AML,...
Signed, sealed, delivered: a generalizable model for living biotherapeutic dosing and metabolism [0.03%]
已签署，已封口，已送达：活生物治疗剂给药和代谢的可推广模型
Vicenzo L DeVito,Bhargav R Karamched
Vicenzo L DeVito
Living Biotherapeutic Products (LBPs) offer a promising therapeutic strategy for metabolic disorders rooted in gut microbiome dysfunction, yet quantitative frameworks for predicting their efficacy remain underdeveloped. We introduce the Bac...
Manifold-based learning for high-throughput single-peanut phenotyping [0.03%]
基于流形的学习在高通量单粒花生表型分析中的应用
Weng Kung Peng,Xiaomin Lin,Peishan Deng et al.
Weng Kung Peng et al.
Peanut (Arachis hypogaea L.), a major legume crop valued for its high oil content, displays complex genotypic-phenotypic interactions shaped by environmental influences, yet these relationships remain poorly understood. We present a high-th...
Overcoming vascular niche-mediated TKI resistance in acute myeloid leukemia through miR-126 inhibition [0.03%]
通过抑制miR-126克服急性髓系白血病中的血管生态位介导的TKI耐药性
Matthew Froid,Sergio Branciamore,Ziang Chen et al.
Matthew Froid et al.
Acute myeloid leukemia (AML) is a hematologic malignancy originating in the bone marrow and often progressing to extramedullary sites. Despite advances in molecularly targeted therapies and hematopoietic stem cell transplantation, clinical ...
Effects of feeding strategies on culture performance and product quality in NISTCHO [0.03%]
投喂策略对密闭循环水系统石斑鱼生长性能和产品质量的影响
Veronika Schäpertöns,Larissa Hofer,Thomas Berger et al.
Veronika Schäpertöns et al.
Monoclonal antibody N-glycosylation is a critical quality attribute influencing therapeutic safety and efficacy, and is strongly influenced by bioprocess design. NISTCHO, a publicly available Chinese hamster ovary producer cell line, is inc...
Context-aware synthetic promoter design using neural networks enables rewiring of eukaryotic transcriptional networks [0.03%]
基于神经网络的上下文感知合成启动子设计可实现真核生物转录网络的重新布线
Lukas Kuhajda,Tomas Honzik,Jan Svec et al.
Lukas Kuhajda et al.
Gene regulation through promoter engineering is a cornerstone of synthetic biology, enabling precise control over transcriptional networks. However, experimental approaches remain labor-intensive. While artificial neural networks (ANNs) hav...
Generative design of synthetic gene circuits for functional and evolutionary properties [0.03%]
具有功能和进化属性的合成基因电路的生成设计
Olivia Gallup,Harrison Steel
Olivia Gallup
In the past decades, a wide suite of design tools for biological systems has been developed, but using these to create biotechnologies that achieve reliable and predictable behaviour remains challenging. Modelling approaches have enabled re...