Single-trajectory Bayesian modeling reveals multi-state diffusion of the MSH sliding clamp [0.03%]
基于单轨迹的贝叶斯模型揭示MSH滑动夹具的多态扩散特性
Seongyu Park,Inho Yang,Jinseob Lee et al.
Seongyu Park et al.
DNA mismatch repair (MMR) is an essential mechanism for preserving genomic integrity across diverse living organisms. In this process, MutS homologs (MSH) play crucial roles in detecting mismatched basepairs and recruiting downstream MMR pr...
Leona M Irwin,Shaun M Cowley,Himanshu Kaul
Leona M Irwin
Human gastrulation remains a black box due to ethical and technical reasons. Human pluripotent stem cell-based 2D micropatterns and 3D organoids (gastruloids) recapitulate aspects of human gastrulation. Understanding the integrated multisca...
Rewiring miR-22/SNAI1 via CRISPR-based edge editing destabilizes the epithelial phenotype [0.03%]
通过CRISPR边缘编辑改变miR-22/SNAI1的相互作用使上皮表型不稳态
John T Nguyen,Lijia Huang,Herbert Levine et al.
John T Nguyen et al.
Epithelial-to-Mesenchymal Transition (EMT) is a critical biological process by which cells acquire enhanced migratory and invasive properties. A key signaling pathway involved in EMT phenotypes includes transforming growth factor β (TGFβ)...
Biomarker identification of triple negative breast cancer subtypes using machine learning [0.03%]
利用机器学习鉴定三阴性乳腺癌亚型的生物标志物
Syed Mohammad,Vaisali Chandrasekar,Ajay Vikram Singh et al.
Syed Mohammad et al.
Triple Negative Breast Cancer is a clinically aggressive and molecularly heterogeneous subtype of breast cancer that currently lacks effective targeted therapies. Recognising biologically distinct subtypes within this disease is crucial for...
Context-aware multi-property antibody predictor: a novel framework integrating text and protein language models [0.03%]
上下文感知多属性抗体预测器：一种集成文本和蛋白质语言模型的新框架
Luca Giancardo,Melih Yilmaz,Edward Lee et al.
Luca Giancardo et al.
Recent advances in Machine Learning have transformed antibody development through in silico models, accelerating therapeutic candidate identification. However, challenges persist: rapid adaptation of property predictors to laboratory-specif...
Liver progenitor cells perform wound healing in a scratch assay by concerted bistable circuits [0.03%]
由协同双稳电路驱动的肝祖细胞在划痕实验中修复损伤
Marija Lazovska,Kristine Salmina,Dace Pjanova et al.
Marija Lazovska et al.
Liver progenitor cells (LPC) exhibit the potential to differentiate into both hepatocytes and cholangiocytes, making them promising candidates for cell therapy in cases of severe liver pathology. However, the mechanisms of LPCs regeneration...
The complexome contextualizes proteomics data to fingerprint biological states and highlight perturbed functional modules in disease [0.03%]
复杂体对蛋白质组数据进行上下文设定以表征生物状态并突出疾病中的功能模块异常
Mainak Guharoy,Isabelle Adant,Matthew Bird et al.
Mainak Guharoy et al.
Analyzing single omics and integrating multimodal omics datasets to capture functional dysregulation in disease remains challenging. Here, we propose a bioinformatics framework that leverages curated datasets of protein complexes ('complexo...
Creating an engine of scientific discovery, an Indo-Japan perspective: learnings from IJNTC 2025 workshop [0.03%]
创造一个科学发现引擎的印度-日本视角：IJNTC 2025研讨会的经验教训
Sucheendra K Palaniappan,Moreno Zolfo,Satish Kottapalli et al.
Sucheendra K Palaniappan et al.
The Nobel Turing Challenge (NTC) proposes AI systems capable of autonomous, Nobel-level scientific discovery. The IJNTC2025 workshop convened researchers from India and Japan to advance this goal in health and biomedicine. This perspective ...
When normalization induces correlation: shared and unstable references can create hidden dependencies [0.03%]
归一化引发相关性：共享引用和不稳定引用会产生隐藏依赖关系
Kiyoshi F Fukutani,Thomas H Hampton,Mattheus Luís Alves Santiago et al.
Kiyoshi F Fukutani et al.
Correlation analyses are widely used to infer biological relationships, yet preprocessing can introduce structural dependencies that inflate correlation estimates. Here, we examine an under-recognized mechanism: shared-reference transformat...
Modeling epithelial deformation and cell rearrangement in response to external forces during Zebrafish epiboly [0.03%]
关于斑马鱼胚盘扩展过程中上皮变形和细胞重新排列的力学模型研究
Sharon B Minsuk,T J Sego,David M Umulis et al.
Sharon B Minsuk et al.
Morphogenesis in early development involves complex and extreme deformations in response to intra- and intercellular forces. Zebrafish epiboly, the spreading of the blastoderm to cover and engulf the large yolk cell, is a key early event th...