Identification of phillyrin as a PPAR-γ ligand through network pharmacology and molecular modeling [0.03%]
网络药理学和分子建模识别 Phillyrin 作为 PPAR-γ 配体
Ling Huang,Zhizheng Fang,Rongchun Han et al.
Ling Huang et al.
Insulin resistance is a core pathological hallmark of metabolic syndromes like type 2 diabetes mellitus. Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a classical therapeutic target for improving insulin sensitivity, yet the...
Karuthedath Shaijal,Meera Joshi,Sanu Shameer
Karuthedath Shaijal
Whole-plant models capture the dynamics of plant architecture and physiology. However, the representation of metabolism in these frameworks remains limited. This work surveys the representation of metabolism in popular mechanistic whole-pla...
Modeling single nucleus microglia across species identifies immune pathways and therapeutic candidates in Alzheimer's disease [0.03%]
跨物种单细胞模型揭示了阿尔茨海默病的免疫通路和治疗靶点
Alexander Bergendorf,Jee Hyun Park,Brendan K Ball et al.
Alexander Bergendorf et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and behavioral changes. A pivotal influence on AD pathology is the dysregulation of microglia in the brain. Despite promising findings in mouse...
Jyoti Jyoti,Hannah Zoller,Wolfgang Zu Castell et al.
Jyoti Jyoti et al.
Understanding the composition of microbial communities in their environment remains a challenge due to the complex interplay of factors like inter-species interactions and nutrient availability. In this context, it has become an established...
Gene prioritization across ancestries uncovers distinct molecular pathophysiology and therapeutic landscape in polycystic ovary syndrome [0.03%]
跨祖先的基因优先级划分揭示了多囊卵巢综合征在分子病理生理学和治疗方面的独特特征
Sindhuja Rajavelu,Debojyoti De
Sindhuja Rajavelu
Polycystic ovary syndrome (PCOS) is a highly prevalent and heterogeneous endocrine disorder affecting women of reproductive age, with substantial reproductive, metabolic, and long-term health consequences. While genome-wide association stud...
A mathematical model of folate-mediated one-carbon metabolism in Down syndrome [0.03%]
唐氏综合症介导的一碳代谢的数学模型
Allison Piovesan,Diletta Poluzzi,Giuseppe Ramacieri et al.
Allison Piovesan et al.
Down syndrome (DS), the most frequent human genetic disorder marked by an extra copy of chromosome 21 (Hsa21) or a portion thereof, leads to physical and cognitive impairments. Following the Lejeune work, researchers focused on a potential ...
A minimal mechanically consistent model of smoothly dividing disk-shaped cells [0.03%]
光滑分裂盘状细胞的最小机械一致性模型
Lukas Hupe,Yoav G Pollack,Jonas Isensee et al.
Lukas Hupe et al.
Replication through cell division is one of the fundamental processes of life and a major driver of dynamics in systems ranging from bacterial colonies to embryogenesis, tissues and tumors. While regulation also shapes self-organization, ma...
Maria Abou Chakra,Nika Shakiba
Maria Abou Chakra
Human development begins with a zygote, yet how this cell forms complex tissues remains a mystery. Progress has been limited by ethical constraints and scarce biological materials. Advances in stem-cell models and virtual twins are now tran...
Characterizing open-ended evolution through undecidability mechanisms in random Boolean networks [0.03%]
通过随机布尔网络中的不可判定机制来表征开放终结进化
Amahury J López-Díaz,Pedro Juan Rivera Torres,Gerardo L Febres et al.
Amahury J López-Díaz et al.
Discrete dynamical models underpin systems biology, but we still lack substrate-agnostic diagnostics for identifying finite-horizon dynamical signatures that may be relevant to open-ended evolution (OEE), such as the recurrent production of...
Resveratrol alleviates intervertebral disc degeneration by regulating ferroptosis of nucleus pulposus cells [0.03%]
白藜芦醇通过调节髓核细胞铁死亡的进程来缓解椎间盘退行性疾病的研究
Xiaoqiang Wang,Jiale Lv,Daqian Zhou et al.
Xiaoqiang Wang et al.
Intervertebral disc degeneration (IVDD) is a major contributor to chronic low back pain, yet its molecular mechanisms remain incompletely understood. Emerging evidence suggests that ferroptosis, an iron-dependent form of regulated cell deat...