Data driven network inference and longitudinal transcriptomics unveil dynamic regulation in Chronic Lymphocytic Leukaemia models [0.03%]
数据驱动的网络推理和纵向转录组学揭示慢性淋巴细胞白血病模型中的动态调节作用
Malvina Marku,Hugo Chenel,Julie Bordenave et al.
Malvina Marku et al.
How do cancer cells respond to their environment, and what are the key regulators behind their behaviour? While immune cell reprogramming in the tumour microenvironment (TME) has been extensively studied, the dynamic regulatory changes with...
Modeling the microRNA regulation of TGF-β/SMAD signaling pathways for seizure control in temporal lobe epilepsy [0.03%]
用于控制颞叶癫痫发作的miRNA调节TGF-β/SMAD信号通路的建模
Kurt J A Pumares,Daniel P Martins,Aiman Khalil et al.
Kurt J A Pumares et al.
Temporal lobe epilepsy (TLE) is the most prevalent type of focal epilepsy. Recent developments in sequencing, proteomics and network analysis tools provide new avenues for investigating potential molecular therapeutic targets. Both the TGF-...
Mechanisms of rectified gap junctional coupling enhancing pacemaking activity of biologically engineered pacemaker cells [0.03%]
整流缝隙连接耦合增强生物工程技术起搏细胞起搏活性的机制研究
Yacong Li,Jun Liu,Xiangyun Bai et al.
Yacong Li et al.
Bio-pacemakers offer a potential alternative to electronic devices, yet their stable implementation at cellular and tissue levels remains unresolved. In this computational study, we aimed to investigate possible effects of the electrotonic ...
Cross-platform metabolomics imputation using importance-weighted autoencoders [0.03%]
基于重要性加权自编码器的跨平台代谢组学数据插补方法
Alexander Smith,Rui Pinto,Loukas Zagkos et al.
Alexander Smith et al.
Metabolomics data are often generated through different platforms and quantification methods which makes their synthesis and large-scale replication challenging. This study developed an ensemble of importance-weighted autoencoders to perfor...
Quantifying and comparing causal patterns in stochastic chemical reaction networks [0.03%]
量化和比较随机化学反应网络中的因果模式
Ozan Kahramanoğulları
Ozan Kahramanoğulları
Chemical reaction networks (CRNs) are broadly used to study biological systems via simulations. Gillespie's Stochastic Simulation Algorithm (SSA) is commonly used to perform stochastic simulations with CRNs. Comparing two CRNs in such a set...
Computational approaches in chemical space exploration for carbon fixation pathways [0.03%]
计算方法在碳固定途径化学空间探索中的应用
Anne-Susann Abel,Nino Lauber,Jakob Lykke Andersen et al.
Anne-Susann Abel et al.
Chemical space exploration is an important part of chemistry and biology, enabling the discovery and optimization of metabolic pathways, advancing synthetic metabolic functions, and understanding biochemical network evolution. We use a grap...
Mathematical modeling of combinatorial antigen targeting with multiple CAR T-cell products for glioblastoma treatment [0.03%]
基于多种CAR-T细胞产品的胶质母细胞瘤治疗的组合抗原靶向的数学建模
Runpeng Li,Michael Barish,Margarita Gutova et al.
Runpeng Li et al.
Glioblastoma is a highly aggressive and difficult-to-treat brain cancer that resists conventional therapies. Recent advances in chimeric antigen receptor (CAR) T-cell therapy have shown promising potential for treating glioblastoma; however...
Delaying cancer progression by integrating toxicity constraints in a model of adaptive therapy [0.03%]
通过在适应性治疗模型中整合毒性的限制来延缓癌症的发展
Jana L Gevertz,Harsh Vardhan Jain,Irina Kareva et al.
Jana L Gevertz et al.
Cancer therapies often fail when intolerable toxicity or drug-resistant cancer cells undermine otherwise effective treatment strategies. Over the past decade, adaptive therapy has emerged as a promising approach to postpone emergence of res...
Rethinking medical education through systems biology to address complexity [0.03%]
通过系统生物学重新思考医学教育以应对复杂性
Laurent David,Pierre-Antoine Gourraud,Guillaume Lamirault et al.
Laurent David et al.
While reductionism has advanced biology and medicine, it fosters a fragmented understanding of health, ill-suited to modern challenges like chronic and systemic diseases. Systems biology offers a new perspective, framing biological entities...
Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation [0.03%]
I型毒素-抗毒素系统中的双稳态可能导致压力诱导的休眠菌形成
Sofija Markovic,Magdalena Djordjevic,Hong-Yu Ou et al.
Sofija Markovic et al.
Antibiotic persistence, characterized by a dormant subpopulation of bacterial cells that causes chronic and recurrent infections, remains poorly understood despite being recognized nearly a century ago. Toxin-antitoxin (TA) systems, which i...