Mariana Monteiro,James Morrissey,Cleo Kontoravdi
Mariana Monteiro
Metabolic network models are widely used in systems and synthetic biology to study cellular metabolism from microbes to mammals. However, their application to mammalian cells remains limited by the scarcity of intracellular flux measurement...
L A Murray,A P Quinn,C Pinali et al.
L A Murray et al.
Myofibril arrangement is critical to cardiac muscle function in health and disease. Historically, analysis of the impact of myofibril organisation on force and cell contraction has relied on the assumption of uniaxial arrays. However, impro...
A double-staining automated flow cytometry method for real-time monitoring of bacteria in continuous bioreactors [0.03%]
连续生物反应器中细菌的在线监测的一种双荧光自动流动检测方法
Juan López-Gálvez,Erik Schönfelder,Hanna Mayer et al.
Juan López-Gálvez et al.
In biotechnological processes, cell density and physiology are critical parameters for controlling the feed rate, harvest time, and process performance. We developed an automated flow cytometry approach that enables continuous, real-time (f...
A proteome optimal allocation model for elucidating effects of temperature on bacterial growth [0.03%]
一种蛋白质组最优分配模型用于阐明温度对细菌生长的影响
Deyu Wang,Qing Zhang,Hualin Shi
Deyu Wang
Although considerable research has been conducted on how bacteria respond to temperature, there are still few studies that use simple protein allocation models to characterize these responses. To bridge this gap, we utilize a protein alloca...
Unifying theories in high-dimensional biophysics: approaches, challenges and opportunities [0.03%]
高维生物物理中的统一理论：方法、挑战和机遇
Marianne Bauer,Akshit Goyal,Sidhartha Goyal et al.
Marianne Bauer et al.
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets. At the ICTS workshop ‘Unifying Theories in High-Dimensional Biophysics’, we discussed whether this high dimensionality poses a challenge...
The SjD Map: an interactive pathway tour into Sjögren's disease signalling mechanisms [0.03%]
SjD地图：一种交互式的途径游览进入Sjögren信号机制
Sacha E Silva-Saffar,Xavier Mariette,Jacques-Eric Gottenberg et al.
Sacha E Silva-Saffar et al.
Sjögren's disease (SjD) remains a major unmet medical challenge, characterised by biological complexity, patient heterogeneity, and the absence of curative treatments. To advance mechanistic understanding and support therapeutic discovery,...
KinForm: kinetics-informed feature optimised representation models for enzyme kcat and KM prediction [0.03%]
基于动力学信息的酶kcat和KM预测的优化表示模型 KinForm
Saleh Alwer,Ronan M T Fleming
Saleh Alwer
Kinetic parameters such as the turnover number (kcat) and Michaelis constant (KM) are essential for modelling enzymatic activity but experimental data remains limited in scale and diversity. Previous methods for predicting enzyme kinetics t...
From FAIR to CURE: guidelines for computational models of biological systems [0.03%]
从FAIR到CURE：生物系统计算模型的指导原则
Herbert M Sauro,Eran Agmon,Michael L Blinov et al.
Herbert M Sauro et al.
Guidelines for managing scientific data have been established under the FAIR principles, requiring that data be Findable, Accessible, Interoperable, and Reusable. In many scientific disciplines, especially computational biology, both data a...
Metabolic gene expression-based stratification and prognostic risk predictive model of head and neck squamous cell carcinoma [0.03%]
基于代谢基因表达的头颈部鳞状细胞癌分层及预后风险预测模型
Soumya Sau,Anjali Gupta,Swastik Sinha et al.
Soumya Sau et al.
Head and neck squamous cell carcinoma (HNSCC) is a complex multivariable disease posing a significant challenge in therapeutics. OXPHOS and PPP are centrally implicated in metabolic heterogeneity influencing tumor behavior, treatment respon...
Multi-omics integration reveals ANXA6-high γδ T cell-endothelial communication as a potential link between periodontitis and MASLD [0.03%]
多组学整合揭示ANXA6高表达的γδT细胞-内皮细胞通讯可能是牙周炎和MASLD联系的关键因素
Zhongxuan Zhang,Zihan Ma,Ruidong Zhang et al.
Zhongxuan Zhang et al.
Periodontitis (PD) and metabolic dysfunction-associated steatotic liver disease (MASLD) were highly prevalent inflammatory disorders that frequently coexisted, yet the molecular basis of their comorbidity remained poorly defined. Here, we a...