Quantifying and comparing causal patterns in stochastic chemical reaction networks [0.03%]
量化和比较随机化学反应网络中的因果模式
Ozan Kahramanoğulları
Ozan Kahramanoğulları
Chemical reaction networks (CRNs) are broadly used to study biological systems via simulations. Gillespie's Stochastic Simulation Algorithm (SSA) is commonly used to perform stochastic simulations with CRNs. Comparing two CRNs in such a set...
Computational approaches in chemical space exploration for carbon fixation pathways [0.03%]
计算方法在碳固定途径化学空间探索中的应用
Anne-Susann Abel,Nino Lauber,Jakob Lykke Andersen et al.
Anne-Susann Abel et al.
Chemical space exploration is an important part of chemistry and biology, enabling the discovery and optimization of metabolic pathways, advancing synthetic metabolic functions, and understanding biochemical network evolution. We use a grap...
Mathematical modeling of combinatorial antigen targeting with multiple CAR T-cell products for glioblastoma treatment [0.03%]
基于多种CAR-T细胞产品的胶质母细胞瘤治疗的组合抗原靶向的数学建模
Runpeng Li,Michael Barish,Margarita Gutova et al.
Runpeng Li et al.
Glioblastoma is a highly aggressive and difficult-to-treat brain cancer that resists conventional therapies. Recent advances in chimeric antigen receptor (CAR) T-cell therapy have shown promising potential for treating glioblastoma; however...
Delaying cancer progression by integrating toxicity constraints in a model of adaptive therapy [0.03%]
通过在适应性治疗模型中整合毒性的限制来延缓癌症的发展
Jana L Gevertz,Harsh Vardhan Jain,Irina Kareva et al.
Jana L Gevertz et al.
Cancer therapies often fail when intolerable toxicity or drug-resistant cancer cells undermine otherwise effective treatment strategies. Over the past decade, adaptive therapy has emerged as a promising approach to postpone emergence of res...
Rethinking medical education through systems biology to address complexity [0.03%]
通过系统生物学重新思考医学教育以应对复杂性
Laurent David,Pierre-Antoine Gourraud,Guillaume Lamirault et al.
Laurent David et al.
While reductionism has advanced biology and medicine, it fosters a fragmented understanding of health, ill-suited to modern challenges like chronic and systemic diseases. Systems biology offers a new perspective, framing biological entities...
Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation [0.03%]
I型毒素-抗毒素系统中的双稳态可能导致压力诱导的休眠菌形成
Sofija Markovic,Magdalena Djordjevic,Hong-Yu Ou et al.
Sofija Markovic et al.
Antibiotic persistence, characterized by a dormant subpopulation of bacterial cells that causes chronic and recurrent infections, remains poorly understood despite being recognized nearly a century ago. Toxin-antitoxin (TA) systems, which i...
Mapping fusion-driven cell reprogramming through integrative single-cell computational frameworks [0.03%]
通过综合单细胞计算框架绘制融合驱动的细胞重编程图谱
Fateme Nazaryabrbekoh,JoAnne Huang,Syeda S Shoaib et al.
Fateme Nazaryabrbekoh et al.
Cell fusion generates hybrid cells with unique traits. To understand the transcriptional and signaling alterations after fusion, we analyzed a published single-cell RNA-sequencing dataset of fused murine cardiomyocytes (mHL1) and mesenchyma...
Modelling dysfunction-specific interventions for seizure termination in epilepsy [0.03%]
构建针对癫痫 seizures 终止的紊乱特异性干预措施模型
Aravind Kumar Kamaraj,Matthew Parker Szuromi
Aravind Kumar Kamaraj
Epileptic seizures result from abnormal synchronous neuronal firing caused by an imbalance between excitatory and inhibitory neurotransmission. While most seizures are self-limiting, those lasting over five minutes, termed status epilepticu...
Author Correction: Neural mechanisms balancing accuracy and flexibility in working memory and decision tasks [0.03%]
作者更正：在工作记忆和决策任务中平衡准确性和灵活性的神经机制
Han Yan,Jin Wang
Han Yan
Published Erratum
NPJ systems biology and applications. 2025 Dec 16;11(1):138. DOI:10.1038/s41540-025-00634-7 2025
Biophysical simulation enables segmentation and nervous system atlas mapping for image first spatial omics [0.03%]
生物物理模拟使图像优先空间组学的分割和神经系统图谱映射成为可能
Lina Mohammed Ali,Aldrin Kay Yuen Yim,Emanuel Gerbi et al.
Lina Mohammed Ali et al.
Spatial omics (SO) produces high-definition mapping of subcellular molecules within tissue samples. Mapping transcripts to anatomical regions requires segmentation, but this remains challenging in tissue cross-sections with tubular structur...