Wrapshap a high dimension feature selection framework to explore biological systems through machine learning explanations [0.03%]
一种通过机器学习解释探索生物系统的高维特征选择框架
Félix Furger,Miguel Thomas,Colas Foulon et al.
Félix Furger et al.
Among the existing feature selection (FS) methods in machine learning (ML), those known as wrapper methods often produce the most effective subset of features. However, their high computational cost and tendency to overfit make them impract...
Artificial intelligence perceives marginal gains from MHC class I haplotype data in antigen presentation predictions [0.03%]
基于MHCⅠ类等位基因数据的抗原提呈预测的人工智能方法得边际收益
Fabio Massimo Zanzotto,Michele Mastromattei,Aleksander Palkowski et al.
Fabio Massimo Zanzotto et al.
Artificial Intelligence offers valuable tools for scientific discovery, but when used improperly, it can cause blunders. In this paper, we report findings related to the role of Major Histocompatibility Complexes (MHCs) in epitope predictio...
Study of wrap mode impact on Pseudomonas aeruginosa motion in the chemotactic field of fungi [0.03%]
缠绕模式对铜绿假单胞菌在真菌化感诱向场中运动影响的研究
Austin Hansen,Alireza Ramezani,Dale A Pelletier et al.
Austin Hansen et al.
An agent-based discrete computational model biologically calibrated to Pseudomonas aeruginosa migration is used to explore the impacts of bacterial reversals and wrap mode on the efficiency of motion in different environments, both with and...
MoCaPS: a machine learning model for stratification of cancer-associated cachexia based on blood biomarkers [0.03%]
基于血液生物标志物的机器学习模型用于癌症恶病质的分层诊断（MoCaPS）
Kayode D Olumoyin,Magaret Park,Evan W Davis et al.
Kayode D Olumoyin et al.
Identification of minimally invasive biomarkers of cancer-associated cachexia may help to recognize high risk patients for progression to more severe cachectic stages. We developed a machine learning-based Model for Cachectic Patients Strat...
Multiscale Modeling of Embryonic Morphogenesis from Fertilization to Organogenesis [0.03%]
从受精到器官发生多尺度建模胚胎形态发生的多尺度模型
Debanik Deb,Orishma Parida,Laasya Naduthota et al.
Debanik Deb et al.
Embryonic development transforms a single cell into a structured multicellular organism through coordinated molecular, cellular, and tissue-level processes. In this review, we discuss multiscale modeling studies spanning early embryogenesis...
Sleep restriction reprograms systemic immunity through NK and T cell crosstalk [0.03%]
睡眠限制通过NK和T细胞互作重新编程全身免疫反应
Zhengyang Qiu,Jichen Jin,Pengqi Zhang et al.
Zhengyang Qiu et al.
Insufficient sleep is a recognized risk factor for inflammatory diseases, yet how sleep loss functionally perturbs immune regulation remains unclear. Here, we apply a multi-omics framework combining two-sample Mendelian randomization, sleep...
Drug-tolerant persisters to TRAIL emerge from a dose-dependent surface in a cell-state continuum of sensitivity [0.03%]
剂量依赖性的细胞状态连续体中产生对TRAIL药物耐受的休眠细胞簇群
Giada Fiandaca,Marielle Péré,Kelian Bonhomme et al.
Giada Fiandaca et al.
Clonal cancer cells show heterogeneous responses to cytotoxic drugs, raising the question of whether this variability reflects discrete phenotypes or a continuum of underlying cell states. We address this by quantifying single-cell caspase-...
The unreasonable likelihood of being: origin of life, terraforming, and AI [0.03%]
存在的不合理可能性：生命起源、地球改造和人工智能
Robert G Endres
Robert G Endres
The origin of life on Earth via the spontaneous emergence of a protocell prior to Darwinian evolution remains a fundamental open question in physics and chemistry. Here, we develop a conceptual framework based on information theory and algo...
Th2 bias and T-cell exhaustion characterize the immunopathology of non-tuberculous mycobacterial pulmonary disease [0.03%]
非结核分枝杆菌肺病的免疫病理特征为 Th2 偏移和 T 细胞耗竭
Tingting Fang,Feifei Yuan,Yu Chen et al.
Tingting Fang et al.
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is an escalating global health concern with poorly defined immunological mechanisms, necessitating comprehensive profiling to guide therapeutic advances. We analyzed peripheral blood ...
Oncostatin M orchestrates collective epithelial migration via HIF1A activation [0.03%]
通过激活HIF1AONSAT介导集体上皮迁移
Ian C McLean,Sean M Gross,Tiera A Liby et al.
Ian C McLean et al.
Extracellular signals strongly influence cell behavior, yet the mechanisms by which specific ligands mediate changes in phenotype remain unclear. The cytokine Oncostatin M (OSM) regulates homeostasis, wound healing, inflammation, and cancer...