Rui Yan,Junping Fan,Cheng Chi et al.
Rui Yan et al.
Glucosinolates (GLSs) play crucial roles in plant defense against herbivores. GTR1 facilitates the high-affinity transport of GLSs through a proton-dependent process. However, the molecular mechanism underlying GLS recognition and transport...
Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia [0.03%]
ODAD1功能丧失变异影响外区隔臂附着并导致原发性纤毛运动障碍中的肌动蛋白细胞骨架重塑
Chunxiao Huo,Ting Luo,Shuo Yang et al.
Chunxiao Huo et al.
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by defective mucociliary clearance due to impaired motile cilia function. Outer dynein arm docking complex subunit 1 (ODAD1) encodes a structural compone...
Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction [0.03%]
补体5a受体2通过PSS-MFN2相互作用介导的MAM形成促进来缓解糖尿病肾病
Yi-Yang Zhao,Yi-Hui Wang,Zi-Han Li et al.
Yi-Yang Zhao et al.
Complement-mediated metabolic disorders are considered important contributors to the pathogenesis of diabetic kidney disease (DKD). This study investigated the non-canonical roles of complement 5a receptor 2 (C5aR2) in metabolism and its un...
Highly regional generation and heterogeneous differentiation of basal cells in mouse trachea [0.03%]
小鼠气管基底细胞的高区域性生成和异质性分化
Xiuxiu Liu,Wendong Weng,Zhen He et al.
Xiuxiu Liu et al.
Structural basis of human zinc-activated channel (ZAC) signaling and modulation [0.03%]
人锌激活通道(ZAC)信号传导和调节的结构基础
Zixuan Zhou,Yonghui Long,Yulin Chao et al.
Zixuan Zhou et al.
Zinc (Zn2+) plays essential roles in a plethora of physiological processes, including key functions as a neuromodulator. The zinc-activated channel (ZAC) belongs to the Cys-loop receptor (CLR) superfamily of pentameric ligand-gated ion chan...
Bilirubin directly activates RIPK3 to induce non-classical necroptosis [0.03%]
胆红素通过直接激活RIPK3诱导非经典坏死型细胞死亡
Qian Xue,Xi Ma,Ziyuan Chen et al.
Qian Xue et al.
Bilirubin, a byproduct of heme metabolism, is traditionally recognized for its antioxidant properties. However, its accumulation under pathological conditions can result in severe clinical manifestations, including neurotoxicity. Here, we r...
Jing Cao,Jie Li,Miaohan Jin et al.
Jing Cao et al.
Rapid production of precisely edited cattle and mice via a single AAV delivered miniature IscB#/ωRNA [0.03%]
一种AAV递送微型IscB/ω-RNA实现精确编辑的小鼠和牛的快速生产
Lishuang Song,Xuefei Liu,Anqi Di et al.
Lishuang Song et al.
Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis [0.03%]
次黄嘌呤通过2,3-BPG-PNP轴促进红细胞代谢重构并恢复氧气释放以达到逆转衰老的效果
Wuping Liu,Zhaoyu Yang,Changhan Chen et al.
Wuping Liu et al.
Aging-related diseases are aggravated by tissue hypoxia; however, the underlying mechanism remains unknown. Here, we report that the oxygen (O2) release capacity of red blood cells (RBCs) gradually decreases with age and is closely associat...
The mitochondrial translocation of phosphorylated EZH2 promotes PARP inhibitor resistance in BRCA1-deficient epithelial ovarian cancer [0.03%]
BRCA1缺陷型卵巢癌中磷酸化EZH2的线粒体易位促进PARP抑制剂耐药性
Ling Hu,Xiaolu Ma,Xushan Cai et al.
Ling Hu et al.
BRCA1-deficient epithelial ovarian cancer (EOC) is reported to respond to poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPis); however, acquired resistance frequently emerges, limiting the long-term clinical efficacy of PARPi...