Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma [0.03%]
整合临床与分子数据可发现具有指导意义的肺腺癌亚型和生物标志物
Jun Shang,He Jiang,Yueren Yan et al.
Jun Shang et al.
Deeper insights into omics in the clinical and tumor microenvironments of lung adenocarcinoma (LUAD) could reveal therapy-sensitive subtypes and novel treatments. From a cohort of 1008 samples from Chinese patients with LUAD with whole-geno...
IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration [0.03%]
IGF2BP3依赖的谷氨酰胺/支链氨基酸代谢重编程可使衰老的人类脂肪衍生干细胞恢复活力并增强组织再生能力
Zichao Li,Lin Feng,Xinxin Wei et al.
Zichao Li et al.
Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo exper...
Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells [0.03%]
L1td1通过转录后调控内源性逆转录病毒获得多能干细胞全能性潜力的抑制作用研究
Yi Wu,Yang Liu,Yile Huang et al.
Yi Wu et al.
Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases [0.03%]
破骨细胞谱系趋化、分化、骨吸收及疾病的细胞信号传导和转录调控
Siyu Zhu,Ming-Qi Yan,Alasdair Masson et al.
Siyu Zhu et al.
Osteoclasts are bone-resorbing cells that play a central role in normal bone remodeling and contribute to bone loss associated with pathological conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, periodontal disease, and...
Julià Agramunt,Yuanbo Kang,Yuval Rinkevich
Julià Agramunt
Mammalian wound healing is orchestrated by tightly regulated cellular and molecular programs across the hemostasis, inflammation, proliferation, and remodeling phases. Here, we propose the concept of spatiotemporal clocks as a unifying fram...
Lineage tracing reveals the origins and dynamics of macrophages in lung injury and repair [0.03%]
谱系追踪揭示了肺损伤和修复过程中巨噬细胞的起源与动态变化过程
Hengwei Jin,Jialing Mou,Huan Zhu et al.
Hengwei Jin et al.
Macrophages play a vital role in tissue repair and regeneration following injury. However, the cell fate, dynamic responses, and functions of macrophages from various origins during lung injury and repair are not fully understood. Here, we ...
Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling [0.03%]
前额皮层-下丘脑环路通过AMPKβ2信号通路调控暗示增强的美味食物摄入行为
Jiakun Xiang,Minghong Shi,Jiajia Kang et al.
Jiakun Xiang et al.
Cognitive factors critically influence appetite and food consumption, contributing to the increasing incidence of obesity in modern obesogenic environments. However, the cellular and molecular mechanisms underlying this phenomenon remain po...
tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells [0.03%]
tRNA m1A修饰对肠道稳态和第3组先天淋巴细胞功能必不可少
Jingyu Li,Zirun Tang,Yunzhu Chen et al.
Jingyu Li et al.
Group 3 innate lymphoid cells (ILC3s) play crucial roles in maintaining intestinal homeostasis and defending against bacterial infections. However, the epigenetic mechanisms that regulate ILC3 responses are not well understood. In this stud...
Luminal hormone-responsive cells tune the regenerative remodeling of mammary glands in large mammals [0.03%]
腔体激素反应细胞调节大型哺乳动物乳腺再生重塑
Yongtao Li,Liping Zhang,Tao Luo et al.
Yongtao Li et al.
The remodeling of mammary glands during pregnancy is essential for initiating lactation. In dairy animals, the overlap of pregnancy and mammary involution triggers a unique process, regenerative remodeling, which is critical for extending l...
Maternal acute SARS-CoV-2 infection impairs preimplantation embryo development and reprograms the early offspring hematopoietic system [0.03%]
母体急性感染SARS-CoV-2损害胚胎植入前发育并重塑后代早期造血系统
Meiling Zhang,Di Liu,Songmao Li et al.
Meiling Zhang et al.
SARS-CoV-2 infection has raised significant concerns regarding its impact on assisted reproductive technology. We found that oocyte retrieval during acute SARS-CoV-2 infection significantly reduced the rates of good-quality blastocyst forma...