Preclinical assessment of GNEwt/bi-shRNA-GNEM743T lipoplex product development for GNE myopathy [0.03%]
用于GNE肌病的GNEwt/bi-shRNAGNEM743T脂质体产品开发的临床前评估
Fabienne Kerneis,Christopher M Jay,Donald Rao et al.
Fabienne Kerneis et al.
Aims: GNE myopathy is a heredity disease of unmet medical need associated with progressive skeletal muscle wasting, atrophy and weakness caused by mutations in the GNE gene. GNE plays a pivotal role in sialic acid product...
Association between circadian rhythm-related behaviors and breast cancer: a bidirectional Mendelian randomization study [0.03%]
昼夜节律相关行为与乳腺癌的双向孟德尔随机化研究
Yan-Yu Hou,Hua-Tao Wu,Wen-Jia Chen et al.
Yan-Yu Hou et al.
Background: Breast cancer (BC) is a major cause of cancer-related morbidity and mortality in women, with its development linked to circadian rhythm disruption. This study employs two-sample bidirectional Mendelian randomi...
Significant but small: the modest impact of population ageing on reported COVID-19 case rates worldwide [0.03%]
显著但有限：人口老龄化对全球新冠肺炎报告病例率的影响较小
Wenpeng You,Frank Donnelly,Luisa Garcia et al.
Wenpeng You et al.
Background: Older adults experienced disproportionate morbidity during the COVID-19 pandemic; however, the independent contribution of population ageing to cross-national variation in reported COVID-19 case rates remains ...
Targeting FMO3 suppresses the malignant phenotype of colorectal cancer: evidence from bioinformatics to functional experiments [0.03%]
靶向FMO3可抑制结直肠癌恶性表型：从生物信息学到功能实验的证据
Rong Su,Cuncun Huang,Zhe Jing et al.
Rong Su et al.
Aims: Flavin-containing monooxygenase 3 (FMO3) is a key metabolic enzyme involved in endogenous metabolism; however, its role in colorectal cancer (CRC) remains poorly understood. This study aimed to investigate the expre...
Soluble cytokine receptor levels in obstructive sleep apnea patients treated with continuous positive airway pressure therapy [0.03%]
持续气道正压治疗对阻塞性睡眠呼吸暂停患者可溶性细胞因子受体水平的影响
Sarah Hall Kiriluk,Lisa A Freeburg,Samira Khan et al.
Sarah Hall Kiriluk et al.
Aims: Continuous positive airway pressure (CPAP) is an established therapy for obstructive sleep apnea (OSA), but how CPAP compliance changes inflammation/cytokine activation remains unclear. ...
Structure-activity insights and molecular modeling approaches of anti-TNBC agents: a comprehensive systematic review [0.03%]
针对抗三阴性乳腺癌药物的构效关系及分子建模研究：全面系统综述
Risqi Ayu Febriana,Dhania Novitasari,Nur Kusaira Khairul Ikram et al.
Risqi Ayu Febriana et al.
Aim: Triple-negative breast cancer (TNBC) is a highly aggressive and treatment-resistant subtype of breast cancer, characterized by the lack of hormone receptor expression. This study aims to comprehensively evaluate the ...
Understanding breast cancer causes: insights from Jordanian women's awareness [0.03%]
了解乳腺癌的病因：约旦女性意识的启示
Ghaith B Heilat,Tahani Alwidyan,Amjad Z Alrosan et al.
Ghaith B Heilat et al.
Objective: To evaluate the awareness and understanding of breast cancer (BC) etiology among Jordanian women and identify associated demographic factors. M...
Diagnosis, evaluation, and management of patients with non-muscle invasive bladder cancer [0.03%]
非肌层浸润性膀胱癌患者的诊断、评估和治疗
Sri Saran Manivasagam,Amar Kassim,Jay D Raman
Sri Saran Manivasagam
Introduction: Non-muscle invasive bladder cancer (NMIBC) accounts for over 75% of bladder cancer cases worldwide and is associated with high recurrence rates and significant surveillance costs. Advances in diagnostic moda...
Ketamine as primary anesthetic for upper limb trauma during war: a case series of 100 surgeries at Rafik Hariri University Hospital, Lebanon's National War Trauma Referral Center [0.03%]
ketamine用于战争中上肢创伤的首选用麻醉药：黎巴嫩国家战争创伤转诊中心Rafik Hariri大学医院100例手术系列报道
Mustapha Nahle,Miguel Nunez,Mayyas Msheik
Mustapha Nahle
Background: The Beirut pager explosions on September 17, 2024 resulted in mass casualties with severe upper limb trauma admitted to Rafik Hariri University Hospital (RHUH), Lebanon's national war trauma referral center. I...
Fulminant disseminated strongyloidiasis mimicking inflammatory bowel disease: a case report [0.03%]
类炎症性肠病型严重强直弓线虫感染一例报告
Oussama Trabelsi,Imen Akkari,Emna Cherif et al.
Oussama Trabelsi et al.
Background: Strongyloidiasis is a gastrointestinal parasitic infection caused by Strongyloides stercoralis (S. stercoralis). Its autoinfection capability allows the parasite to persist lifelong in the absence of treatment...