Pathway dysregulation and therapeutic resistance in glioblastoma: molecular mechanisms and emerging therapeutic targets [0.03%]
胶质母细胞瘤的通路失调与治疗抵抗：分子机理及新兴治疗靶点
William Li,Jia Ming Chen,Yi Chao Ma
William Li
The review further examines mechanisms underlying treatment resistance and the limitations of current targeted therapies. Although many pathway-directed treatments have demonstrated promising preclinical activity, clinical translation remai...
Drug-Induced liver injury with adebrelimab: how to assess causality using the updated RUCAM? [0.03%]
阿得贝利单抗所致药物性肝损伤的致病关联评估——应用更新后的RUCAM量表如何打分？
Jie Min,Li Liu,Si-Qin Sun et al.
Jie Min et al.
Aim: To report a case of Adebrelimab-related liver injury and emphasize the role of the updated RUCAM in causality assessment for suspected immune checkpoint inhibitor-induced hepatotoxicity. ...
Real-world evidence on off-label underdosing of direct oral anticoagulants in Asian patients with atrial fibrillation: prescribing patterns, determinants, and outcomes [0.03%]
口服直接凝血酶抑制剂在亚洲房颤患者中的实际应用剂量不足：用药模式，影响因素及转归
Pajaree Mongkhon,Tanaphorn Koonlachad,Purachai Bvornphattanasakul et al.
Pajaree Mongkhon et al.
Background: Off-label underdosing of direct oral anticoagulants (DOACs) is common among Asian patients with atrial fibrillation (AF), partly reflecting concerns about bleeding, yet Southeast Asian data remain limited. Thi...
Comment on: 'Ultrasound-guided injection strategies for lateral epicondylitis-a multicenter randomized comparison of corticosteroid, platelet-rich plasma, and ozone' [0.03%]
关于“侧副韧带炎超声引导注射策略的多中心随机对照研究：皮质类固醇、富血小板血浆和臭氧的比较”的评论
Ritu Raj Singh,Sunita Sharma,Aiyesha Khatun
Ritu Raj Singh
Ozone therapy by rectal insufflation in long COVID syndrome: a preliminary study with thermographic evaluation and quality of life measurement [0.03%]
长新冠综合征的臭氧治疗：初步研究（含热图评估和生活质量测量）
Raquel Sacristan Perez,Maria José Martínez Vivas,Silvia Menéndez-Cepero et al.
Raquel Sacristan Perez et al.
Introduction: Post-acute coronavirus disease 2019 syndrome (PACS) is a multisystemic clinical condition that clinically starting weeks or even months after acute SARS-CoV-2 (COVID 19) infections. The objective of this stu...
Evolution and future directions of bispecific antibodies in breast cancer: a global clinical trial landscape analysis [0.03%]
双特异性抗体在乳腺癌中的进化和未来方向：全球临床试验格局分析
Xubin Zhu,Shiyou Luo,Yiheng Li
Xubin Zhu
USP14 promotes head and neck squamous cell carcinoma progression via deubiquitinating and stabilizing CFL2 [0.03%]
USP14通过去泛素化和稳定CFL2促进头颈部鳞状细胞癌进展
Yue Liu,Zhiyuan Wang,Weixing Liu et al.
Yue Liu et al.
Aim: To identify novel substrates of USP14 and elucidate the molecular mechanisms by which USP14 promotes head and neck squamous cell carcinoma (HNSCC) progression. ...
Global burden and trends of stomach cancer, Colon and rectum cancer, peptic ulcer disease, and gastritis and duodenitis from 1990 to 2021: a systematic analysis for the global burden of disease study 2021 [0.03%]
1990年至2021年全球胃癌、结直肠癌、消化性溃疡病和胃肠炎及十二指肠炎的疾病负担和趋势：2021年度全球疾病负担研究系统分析报告
Quan-Yao Li,Hui Liu,Wen-Chao Qiu et al.
Quan-Yao Li et al.
Background: Geographical disparities are evident in the burden of digestive system diseases. To date, however, a comparative analysis that simultaneously examines the burden of common digestive cancers alongside non-malig...
An experimental study on the role of naloxone in facilitating alcohol metabolism in acute alcohol intoxication rats [0.03%]
纳洛酮促急性乙醇中毒大鼠体内乙醇代谢的实验研究
Ziqi Jin,Yingqi Hu,Xuqi Liu et al.
Ziqi Jin et al.
Objectives: Naloxone has been used in acute alcohol intoxication (AAI) in China and some other Asian countries. However, the effects of naloxone on alcohol metabolism and its mechanisms are unclear. This study aimed to ex...
Clinical immunogenicity and pharmacokinetic assessments of E3112, a recombinant human hepatocyte growth factor [0.03%]
重组人肝细胞生长因子E3112的临床免疫原性和药代动力学评估
Muneo Aoyama,Toshiyuki Takanohashi,Fuminori Ohba et al.
Muneo Aoyama et al.
Aims: E3112 is a recombinant human hepatocyte growth factor (HGF) intended for the treatment of acute liver failure. As the presence of anti-drug antibody (ADA) against E3112 could pose a significant risk in clinical sett...