Netrin-1 and B-cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives [0.03%]
网状蛋白-1和B细胞成熟抗原在淋巴瘤队列中的表达：浆细胞样淋巴瘤的敏感及特异性染色及相关治疗展望
Marie Donzel,Alexis Trecourt,Hervé Ghesquières et al.
Marie Donzel et al.
Netrin-1 and B-cell maturation antigen (BCMA) are currently being evaluated as therapeutic targets in oncology. However, studies investigating their expression in mature human lymphoid malignancies are sparse. This study aimed to investigat...
Genomic features of liquid biopsies from patients with prostate cancer with and without ductal adenocarcinoma [0.03%]
前列腺癌患者液态活检的基因组特征（伴有或不伴有导管腺癌）
Qiyu Zhu,Ting Wang,Yifu Shi et al.
Qiyu Zhu et al.
Ductal adenocarcinoma of the prostate (DA) is relatively rare and highly co-existent with prostate adenocarcinoma (AC). This study aimed to investigate the distinctive genomic profiles of patients with DA compared to those without. Blood sa...
MMR deficiency is frequent in colorectal carcinomas with diffuse SLFN11 immunostaining: clinicopathologic and molecular study of 31 cases identified among 3,300 tumors [0.03%]
弥漫性SLFN11免疫染色的结直肠癌中常出现MMR缺陷：在3300肿瘤中鉴别出的31例病例的临床病理及分子研究
Maciej Kaczorowski,Małgorzata Chłopek,Ondřej Daum et al.
Maciej Kaczorowski et al.
Schlafen 11 (SLFN11), a regulator of cell fate following DNA injury, sensitizes tumor cells to DNA-damaging agents. Patients with SLFN11-positive tumors may benefit from DNA-damaging chemotherapies. SLFN11 has been studied in different type...
Do explainable AI (XAI) methods improve the acceptance of AI in clinical practice? An evaluation of XAI methods on Gleason grading [0.03%]
可解释的人工智能(XAI)方法是否能提高临床实践中对人工智能的接受度？在Gleason分级上对XAI方法的评估
Robin Manz,Jonas Bäcker,Samantha Cramer et al.
Robin Manz et al.
This work aimed to evaluate both the usefulness and user acceptance of five gradient-based explainable artificial intelligence (XAI) methods in the use case of a prostate carcinoma clinical decision support system environment. In addition, ...
Costs of biomarker testing in advanced non-small cell lung cancer: a global study comparing next-generation sequencing and single-gene testing [0.03%]
晚期非小细胞肺癌生物标志物检测的成本：一项比较下一代测序和单一基因检测的全球研究
Umberto Malapelle,Chien-Chin Chen,Enrique de Álava et al.
Umberto Malapelle et al.
Current European/US guidelines recommend that molecular testing in advanced non-small cell lung cancer (aNSCLC) be performed using next-generation sequencing (NGS). However, the global uptake of NGS is limited, largely owing to reimbursemen...
Observational Study
The journal of pathology. Clinical research. 2025 Mar;11(2):e70018. DOI:10.1002/2056-4538.70018 2025
Enhancing HER2 testing in breast cancer: predicting fluorescence in situ hybridization (FISH) scores from immunohistochemistry images via deep learning [0.03%]
提高乳腺癌HER2检测水平：通过深度学习从免疫组化图像预测荧光原位杂交(FISH)评分
Daniel O Macaulay,Wenchao Han,Mark D Zarella et al.
Daniel O Macaulay et al.
Breast cancer affects millions globally, necessitating precise biomarker testing for effective treatment. HER2 testing is crucial for guiding therapy, particularly with novel antibody-drug conjugates (ADCs) like trastuzumab deruxtecan, whic...
Oncocytic and spindle cell typical carcinoids of lung: different immunophenotype and biological behavior [0.03%]
肺嗜酸细胞和梭形细胞典型类癌：不同的免疫表型及生物学行为
Giovanna Sabella,Giovanni Centonze,Patrick Maisonneuve et al.
Giovanna Sabella et al.
Pulmonary typical carcinoids (TCs) are uncommon, well-differentiated neuroendocrine tumors of the lung that do not exhibit necrosis and have fewer than two mitoses per 2 mm2, as defined by the current World Health Organization classificatio...
Association between individual Warburg-related proteins and prognosis in colorectal cancer [0.03%]
沃伯格相关蛋白与结肠癌预后的关联研究
Kelly Offermans,Josien Ca Jenniskens,Colinda Cjm Simons et al.
Kelly Offermans et al.
We previously showed that Warburg subtyping (low/moderate/high), based on the expression of six glycolytic proteins and transcriptional regulators [glucose transporter 1 (GLUT1), pyruvate kinase M2 (PKM2), lactate dehydrogenase A (LDHA), mo...
Comprehensive transcriptomic profiling reveals molecular characteristics and biomarkers associated with risk stratification in papillary thyroid carcinoma [0.03%]
全面转录组分析揭示了与乳头状甲状腺癌风险分层相关分子特性和生物标志物
Congcong Yan,Chen Zheng,Jiaxing Luo et al.
Congcong Yan et al.
Papillary thyroid carcinoma (PTC) is one of the most common endocrine malignancies, with varying levels of risk and clinical behavior. A better understanding of the molecular characteristics could improve molecular diagnosis and risk assess...
Sarcomatoid areas of urothelial carcinoma are enriched for CD163-positive antigen-presenting cells [0.03%]
尿路上皮癌的肉瘤样区域富含CD163阳性的抗原呈递细胞
Burles A Johnson rd,Vamsi Parimi,Sonia Kamanda et al.
Burles A Johnson rd et al.
Sarcomatoid urothelial carcinoma (SUC) is a rare histologic subtype with poor prognosis. While there is known intra-tumoral heterogeneity between individual SUC tumors, the relationship between sarcomatoid and conventional urothelial carcin...