Genomic profiling of Mexican patients with B-cell precursor acute lymphoblastic leukemia reveals clinically significant somatic and potential germline variants [0.03%]
墨西哥B细胞前体急性淋巴细胞白血病患者的基因组谱分析揭示了临床意义重大的体细胞性和潜在的胚系变异
Daniel Martínez Anaya,María Del Rocío Juárez-Velázquez,Ulises Juárez Figueroa et al.
Daniel Martínez Anaya et al.
B-cell precursor acute lymphoblastic leukemia (preB-ALL) is characterized by pathogenic variants currently used in precision oncology. However, the mutational landscape of Mexican children with preB-ALL has not yet been thoroughly explored ...
Not all NTRK fusions in mesenchymal neoplasia are driver events: implications on classification and targeted therapy [0.03%]
并非肉瘤中的所有NTRK融合均为驱动基因改变：对分类和靶向治疗的启示
Mohamed A Yakoub,Purvil Sukhadia,Carla Saoud et al.
Mohamed A Yakoub et al.
NTRK fusions drive the pathogenesis of a distinctive group of mesenchymal neoplasms with significant impact on classification and targeted therapy. However, unexpected NTRK fusions have been reported in other sarcoma entities, raising uncer...
Immune checkpoint profiling of B7-H proteins predicts survival and treatment response in metastatic clear cell renal cell carcinoma [0.03%]
B7-H蛋白免疫检查点谱分析可预测转移性透明细胞肾癌患者的预后和治疗反应
Maite Emaldi,Esther Rey-Iborra,Lorena Mosteiro et al.
Maite Emaldi et al.
The B7-H family of immune checkpoint proteins plays a central role in tumor immune regulation, yet their prognostic and predictive significance in metastatic clear cell renal cell carcinoma (ccRCC) remains incompletely defined. We analyzed ...
Clinical and molecular correlates of digitally quantified anthracosis in lung tissue slides: utility of an automated quantitative workflow [0.03%]
基于肺组织切片的数字化煤尘沉着症量化定量工作流程的临床和分子相关性研究：自动化定量工作流程的有效性研究
Lucas C Fung,Brenden Joseph,Kenneth Ofori-Amanfo et al.
Lucas C Fung et al.
Air pollution, such as particulate matter with a diameter of ≤2.5 μm (PM2.5) is a major contributor to lung cancer in the never-smoking population. Anthracotic pigments (black deposits in the lungs) are physical evidence of environmental ...
Tumor-type-specific expression of TTF-1 in primary central nervous system tumors classified by the 2021 WHO criteria [0.03%]
基于2021年WHO分类的原发中枢神经系统肿瘤中TTF-1表达的肿瘤特异性分布
Lu Xu,Hong-Jiu Ren,Jian Gu et al.
Lu Xu et al.
Thyroid transcription factor-1 (TTF-1) is a widely used immunohistochemical marker for tumors of thyroid and pulmonary origin; however, its expression profile and diagnostic relevance in primary central nervous system (CNS) tumors remain in...
Mechanosensitive TRPV4 immunohistochemistry improves deep learning-based classification of ductal carcinoma in situ beyond H&E morphology [0.03%]
机械敏感型TRPV4免疫组化通过HE染色形态学以外的特征改进了对导管原位癌的基于深度学习的分类
Janghyun Yoo,Raghav Karthikeyan,Kashi Kamat et al.
Janghyun Yoo et al.
Ductal carcinoma in situ (DCIS) spans a biologic continuum from atypical ductal hyperplasia (ADH) to high-grade lesions with variable risk of progression to invasive ductal carcinoma (IDC), yet morphologic assessment by hematoxylin and eosi...
MET-amplified gastric cancers exhibit co-amplifications of BRAF, CDK6, and EGFR [0.03%]
MET扩增的胃癌中BRAF、CDK6和EGFR共扩增
Silke Lüschen,Ulrike Ebert,Hans-Michael Behrens et al.
Silke Lüschen et al.
MET-positive gastric cancer (GC) has a poor prognosis. In addition, targeting MET with monoclonal antibodies or tyrosine kinase inhibitors had limited success. We searched for additional genetic alterations that might explain the poor outco...
SOX10 distinguishes oligodendrogliomas from low-grade glioneuronal tumors/low-grade gliomas with oligodendrocyte-like features [0.03%]
SOX10可区分少突胶质瘤与具有少突胶质细胞样特征的低级别胶质神经元肿瘤/低级别glioma
Danmei Zhou,Xiaomu Hu,Yin Wang et al.
Danmei Zhou et al.
Oligodendrogliomas exhibit significant morphological overlap with low-grade glioneuronal tumors/low-grade gliomas with oligodendrocyte-like features, posing challenges in histopathological diagnosis. SOX10, a transcription factor critical f...
Pan-TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative activity [0.03%]
神经胶质瘤中泛-TRK表达与NTRK基因异常及肿瘤分级和增殖活性之间的关系研究
Yinan Zhu,Mingfang Sun,Wanchen Lu et al.
Yinan Zhu et al.
Tropomyosin receptor kinase (TRK) fusions are actionable oncogenic drivers, and pan-TRK immunohistochemistry (IHC) serves as a reliable screening tool for NTRK gene aberrations. However, the expression profile and clinical significance of p...
Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle-invasive bladder cancer [0.03%]
肌侵袭性膀胱癌中CD39和CD73表达水平独立且相反地预示生存率
Stephan Ledderose,Julia Schwenke,Lennert Eismann et al.
Stephan Ledderose et al.
Bladder cancer is one of the leading causes of cancer-related mortality worldwide. Long-term survival is particularly poor in patients with muscle-invasive bladder cancer (MIBC). Modulation of purinergic signaling through the ectonucleotida...