Automated tumor-stroma ratio estimation for improved prognostic stratification of squamous cell carcinoma of the oral tongue [0.03%]
自动估算舌鳞癌肿瘤-基质比率以改善预后分层
Lixiao Wang,Katrine Sörensen,Philip J Coates et al.
Lixiao Wang et al.
Squamous cell carcinoma of the oral tongue (SCCOT) represents an aggressive malignancy characterized by high metastatic potential and significant heterogeneity in its tumor microenvironment. The tumor-stroma ratio (TSR) has emerged as a pro...
NDRG1 is a prognostic biomarker in breast cancer and breast cancer brain metastasis [0.03%]
NDRG1是乳腺癌和乳腺癌脑转移的预后生物标志物
Vaibhavi Joshi,Andrew Stacey,Yufan Feng et al.
Vaibhavi Joshi et al.
Brain metastases are secondary brain tumours characterised by their aggressive nature and poor prognosis. Breast cancer is one of the most common primary tumours in women to spread to the brain. A lack of biomarkers predicting likely spread...
Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers [0.03%]
透明质酸堆积与肾细胞癌中透明质酸酶表达降低相关，CD44、HAS1和HYAL2成为预后标志物
Otto Jokelainen,Teemu Rintala,Satu Remes et al.
Otto Jokelainen et al.
Hyaluronan (HA), a large extracellular matrix glycosaminoglycan, is associated with malignant features in several human cancers. The accumulation of HA in renal cell carcinomas (RCC) correlates with unfavorable outcomes, higher tumor grade,...
Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial [0.03%]
GUSTO临床试验中膀胱癌分子分型的验证
Jon Griffin,Jenny Down,Lewis A Quayle et al.
Jon Griffin et al.
The GUSTO clinical trial (Gene expression subtypes of Urothelial carcinoma: Stratified Treatment and Oncological outcomes) uses molecular subtypes to guide neoadjuvant therapies in participants with muscle-invasive bladder cancer (MIBC). Be...
Leveraging deep learning to discover interpretable cellular spatial biomarkers for prognostic predictions based on hepatocellular carcinoma histology [0.03%]
基于肝细胞癌组织学的深度学习可解释性细胞空间生物标志物的发现用于预后预测
Huijuan Hu,Tianhua Tan,Yerong Liu et al.
Huijuan Hu et al.
The spatial structure of various cell types in the tumour microenvironment (TME) can provide valuable insights into disease progression. However, identifying the spatial organization of diverse cell types that significantly correlates with ...
A quantitative tumor-wide analysis of morphological heterogeneity of colorectal adenocarcinoma [0.03%]
结直肠腺癌形态异质性的定量分析
Mihnea P Dragomir,Vlad Popovici,Simon Schallenberg et al.
Mihnea P Dragomir et al.
The intertumoral and intratumoral heterogeneity of colorectal adenocarcinoma (CRC) at the morphologic level is poorly understood. Previously, we identified morphological patterns associated with CRC molecular subtypes and their distinct mol...
Entropy and expertise: assessing changes in pathologists' language over time using the UK Liver Pathology External Quality Assessment scheme [0.03%]
基于熵和专家意见的评测：使用英国肝脏病理外部质量评估方案随时间变化的语言评估病理学家的意见
Jonathan P Callaghan,Katrina Z Freimane,Rachel M Brown et al.
Jonathan P Callaghan et al.
External Quality Assessment (EQA) schemes are an important quality assurance tool and aim to ensure consistency among histopathologists. In this study, we use Shannon entropy as a novel metric to evaluate linguistic variability in the UK Li...
Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer [0.03%]
三种替代的结直肠癌侵袭性肿瘤前缘组织病理评分方法的研究
Walaiphorn Woraharn,Ashley McCulloch,Christopher Bigley et al.
Walaiphorn Woraharn et al.
Although the characteristics at the invasive tumour front in colorectal cancer (CRC) are simple to assess, they are not included in routine pathology reports because they lack reproducibility and standardisation. In this study, we aimed to ...
Emerging pathological diagnostic strategies for solid pseudopapillary neoplasm of the pancreas: insights from omics and innovative techniques [0.03%]
胰腺实体假乳头状瘤的新兴病理诊断策略：来自组学和创新技术的新见解
Yuanhao Liu,Junya Peng,Yupei Zhao et al.
Yuanhao Liu et al.
Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low-grade malignant tumor, representing 0.9-2.7% of all exocrine pancreatic tumors. SPN patients generally have a favorable prognosis with a 5-year survival rate exceeding 95% ...
AXL and SRC in clear cell renal cell carcinoma: absence of mutations, rare alternative splicing events, but association of protein expression with poor prognosis [0.03%]
AXL和SRC在透明细胞肾细胞癌中的作用：无突变，罕见的剪接事件，但蛋白表达与不良预后相关
Muriel D Brada,Tülay Karakulak,Peter Schraml et al.
Muriel D Brada et al.
Novel treatment options for metastatic renal cell carcinomas (RCC) include specific MET inhibitors, GAS6/AXL inhibitors, and SRC inhibitors. The interplay between c-MET, SRC, AXL expression, and their gene mutation patterns in different ren...