Myeloid sarcoma shows a high frequency of mutations activating the MAPK/ERK pathway and association with clonal hematopoiesis [0.03%]
髓系肉瘤显示MAPK / ERK途径激活突变频率较高，并与克隆造血相关
Dominik Nann,Tim-Colin Schade,Mathis Overkamp et al.
Dominik Nann et al.
Myeloid sarcoma (MS) is a mass-forming extramedullary manifestation of myeloid blasts, either in relation to an underlying acute myeloid leukemia (AML), another myeloid neoplasm (MN) or as a de novo occurrence. Data on the genetic profile o...
Translational milestones in urologic pathology: integrating molecular diagnostics across cancer types [0.03%]
泌尿病理的转化里程碑：各类癌症分子诊断的整合
Andres Matoso,Andres M Acosta
Andres Matoso
In its first decade, The Journal of Pathology: Clinical Research has become a leading source of translational studies advancing molecular diagnostics in cancer, particularly in urologic pathology. This commentary highlights recent contribut...
MYCN amplification defines an aggressive phenotype in IDH-mutant gliomas [0.03%]
MYCN扩增界定了IDH突变型胶质瘤的一个侵袭性亚型
Xujun Xie,Qin Yan,Fang Wang et al.
Xujun Xie et al.
In alignment with the latest WHO classification system, which underscores the integration of molecular alterations in glioma diagnosis and grading, this study investigates the prognostic significance of MYCN amplification in IDH-mutant glio...
Assessing PD-L1 expression in non-small cell lung carcinoma: a prospective study of matched fine-needle aspirates, core biopsies, and resection specimens using alcohol and forming fixatives [0.03%]
配对细针吸取物、核心活检和切除标本中评估非小细胞肺癌的PD-L1表达：使用酒精和_forming固定剂的前瞻性研究
Alexander Haragan,Natalie Kipling,Michael Shackcloth et al.
Alexander Haragan et al.
PD-L1 expression for the prediction of response to immune-checkpoint blockade remains the most broadly utilised clinically validated biomarker in a range of tumour types. In this study, we aimed to assess, in a prospectively collected match...
Targeting the cancer glycocalyx in salivary duct carcinoma: tumor-associated mucin 1 (Tn-MUC1) as a novel cell surface marker [0.03%]
靶向唾液管癌的癌症糖萼：肿瘤相关黏蛋白1（Tn-MUC1）作为新型细胞表面标志物
Masashi Kuroki,Ryo Kawaura,Hiroyuki Tomita et al.
Masashi Kuroki et al.
Despite the use of targeted drugs for human epidermal growth factor receptor type 2 (HER2)-positive salivary duct carcinoma (SDC) treatment, the overall prognosis for SDC remains poor. In this study, we aimed to investigate whether the glyc...
Development of a prognostic risk model for clear cell renal cell carcinoma by systematic evaluation of DNA methylation markers: an update after ISUP/WHO 2022 classification [0.03%]
系统评估DNA甲基化标记物后透明细胞肾细胞癌预后风险模型的开发：ISUP/WHO 2022分类更新后的研究
Selena Odeh,Iryna Samarska,Andres Matoso et al.
Selena Odeh et al.
Although several prognostic models have been developed for clear cell renal cell carcinoma (ccRCC), these are still suboptimal and there is a need to identify additional prognostic biomarkers. Previously, we developed a prognostic model con...
Synchronous endometrial/cervical and ovarian/fallopian tube carcinoma: a genome-wide mutation analysis [0.03%]
同步子宫内膜/宫颈癌和卵巢/输卵管癌的全基因组突变分析
Lihong Li,Mengfei Yao,Luyuan Li et al.
Lihong Li et al.
In this study, we explored the genomic underpinnings of synchronous endometrial and ovarian/fallopian tube carcinoma (SEOC) and synchronous cervical and ovarian/fallopian tube carcinoma (SCOC), focusing on their clonal relationships to disc...
Tumor-associated macrophages: potential role in skeletal involvement in classic Hodgkin lymphoma [0.03%]
肿瘤相关巨噬细胞在经典霍奇金淋巴瘤骨骼受累中的潜在作用
Maja Dam Andersen,Katharina Wolter,Marie Hairing Enemark et al.
Maja Dam Andersen et al.
The biology of tumor spread to bone is poorly understood, not least in classic Hodgkin lymphoma (cHL). We used gene expression profiling and immunohistochemistry to characterize the nodal tumor microenvironment of cHL cases with and without...
Which descriptor should spread through air spaces (STAS) be incorporated into? T descriptor versus residual tumor classification [0.03%]
STAS应归于T分期还是残余肿瘤分类？
Yedong Mi,Donglai Chen,Zhangqiang Chen et al.
Yedong Mi et al.
It has not been determined which descriptor spread through air spaces (STAS) should be incorporated into the context of the ninth Tumor, Node and Metastasis (TNM) staging system: the T or the uncertain resection [R(un)] category. A multicen...
Pathogenesis of peritoneal high-grade serous carcinoma after risk-reducing surgery: a systematic review [0.03%]
风险减除手术后腹膜高级别浆液性癌发病机制的系统评价
Tamar A Gootzen,Anouk B Bouwmeester,Joanne A de Hullu et al.
Tamar A Gootzen et al.
Germline BRCA1/2 pathogenic variant carriers have an increased risk for high-grade serous carcinoma (HGSC) and are therefore advised to have risk-reducing salpingo-oophorectomy around the age of 40. However, a risk of 0.9% to develop perito...