Diffuse glioma with FGFR3-TACC3 fusion in adults is not a homogenous clinicopathological and molecular entity [0.03%]
成人弥散性胶质瘤中的FGFR3-TACC3融合不是同质的临床病理和分子实体
Xiaoli Su,Jiawen Wu,Pingling Wang et al.
Xiaoli Su et al.
Adult diffuse gliomas with FGFR3-TACC3 (F3T3) fusion are rare and highly heterogeneous central nervous system (CNS) tumors. Current research on the biological behavior of these tumors is limited, especially regarding whether histopathologic...
The diagnostic landscape of bone and soft tissue sarcoma: the pan-sarcoma era and AI-driven classification [0.03%]
骨和软组织肉瘤的诊断格局：泛肉瘤时代与人工智能驱动分类法
William Ch Cross
William Ch Cross
Bone and soft tissue sarcomas are a diagnostic challenge due to their histological complexity, variety, and mutational heterogeneity. This has led to continued refinements in classification and diagnostic criteria, presented and soon to be ...
Inter-rater agreement of HER2-low scores between expert breast pathologists and the Visiopharm digital image analysis application (HER2 APP, CE2797) [0.03%]
专家乳腺病理学家与Visiopharm数字图像分析应用程序（HER2 APP，CE2797）之间的HER2低评分的评分者一致性
Suzanne Parry,Lila Zabaglo,Abeer M Shaaban et al.
Suzanne Parry et al.
Inter-observer concordance data for the HER2 category as assessed by a group of 16 specialist breast pathologists on 50 diagnostic core biopsies was compared with that produced by digital image analysis (DIA) using the HER2 APP, CE2797 (VP ...
Cribriform pattern and IDC-P in prostate biopsies: prognostic relevance and reporting in metastatic disease [0.03%]
筛状结构和IDC-P在前列腺活检中的预后意义及转移性疾病报告中的注意事项
Yoichiro Okubo,Rika Kasajima,Shinya Sato et al.
Yoichiro Okubo et al.
Cribriform pattern and intraductal carcinoma of the prostate are recognized adverse histological features, yet their prognostic value in treatment-naïve metastatic disease remains uncertain. We conducted a single-center retrospective study...
Histopathology-based assessment of the tumour microenvironment in gastrointestinal cancers: practical approaches to prognostication and treatment stratification [0.03%]
基于病理组织学的胃肠道癌症肿瘤微环境评估：预后和治疗分层的方法学实践
Shelly Yunbi Ni,Howard Ho-Wai Leung,Anthony Wing-Hung Chan
Shelly Yunbi Ni
The tumour microenvironment (TME) is a key factor in carcinogenesis by affecting tumour growth, invasion, metastasis, and drug resistance. Histopathology and immunohistochemistry provide accessible and reproducible methodologies for TME eva...
Reduced GATA3 expression associates with immuno-metabolic alterations and aggressive features in breast cancer [0.03%]
GATA3低表达与乳腺癌的免疫代谢改变及侵袭性表型相关
Anna Km Sæle,Amalie A Svanøe,Cecilie Askeland et al.
Anna Km Sæle et al.
In breast cancer (BC), the transcription factor GATA3 is linked to estrogen receptor (ER) alpha biology, and its loss is associated with aggressive tumor features. Little is reported about potential roles and implications of GATA3 independe...
Computational pathology in the age of artificial intelligence - embrace not fear [0.03%]
人工智能时代下的计算病理学——拥抱而不是恐惧
Alfonso Tan-Garcia,Tzy Harn Chua,Wei-Qiang Leow
Alfonso Tan-Garcia
Anatomical pathology has traditionally relied on the interpretation of histomorphological features under a light microscope by trained pathologists for diagnosis. Technological advancements have enabled the digitisation of tissue slides to ...
Automated multi-regional IHC scoring enhances prognostication in colorectal cancer [0.03%]
自动的多区域IHC评分可提高结直肠癌预后判断能力
Jun Cheng,Yulong Han,Ye Yuan et al.
Jun Cheng et al.
The tumor immune microenvironment plays a critical role in colorectal cancer (CRC) prognosis. However, most studies assess a limited set of immune markers manually in the tumor region, without considering immune heterogeneity across multipl...
Histological types of invasive breast cancer in 830,000 women diagnosed in England during 1988-2016 [0.03%]
1988年至2016年英格兰新诊断的83万名乳腺癌患者的病理类型分布情况
Jake Probert,John Broggio,Sarah C Darby et al.
Jake Probert et al.
Breast cancer can be categorised into a number of histological types, based on microscopic appearances. There is some evidence that the different breast cancer histological types are associated with different patient and tumour characterist...
Somatic whole exome sequencing of colorectal carcinoma in young patients from sub-Saharan Africa reveals novel insights [0.03%]
来自东非年轻患者的结直肠癌全外显子组测序研究揭示了新的科学见解
Alessandro Pietro Aldera,Dennis Owusu,Leonardo Biral et al.
Alessandro Pietro Aldera et al.
Colorectal carcinoma (CRC) is a frequent cause of morbidity and mortality in sub-Saharan Africa. The incidence of early-onset, microsatellite stable (MSS) CRC is on the rise, and the tumour biology of these lesions is poorly categorised. Pr...