Cancer-associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi-omics and machine learning analysis [0.03%]
癌症相关成纤维细胞与结肠腺癌中CD8+T细胞耗竭及预后不良有关：多组学和机器学习分析
Myungsun Shim,One-Zoong Kim,Byoung Kwan Son et al.
Myungsun Shim et al.
Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer-associated fib...
Expression of Nectin-4 and Trop-2 in upper tract urothelial carcinoma: implications for biomarker-driven antibody-drug conjugate therapy [0.03%]
nectin-4和trop-2在上尿路尿路上皮癌中的表达：抗体药物偶联物治疗的生物标志物意义
Ping Shi,Qingqing Wu,Yong Zhang et al.
Ping Shi et al.
Recent advancements in antibody-drug conjugates, including FDA-approved therapies targeting Nectin-4 and Trop-2, have transformed the cancer treatment landscape, including upper tract urothelial carcinoma (UTUC). However, varied treatment e...
AI for pathologists: a universal lymph node metastasis detection app that enhances efficiency while preserving diagnostic accuracy [0.03%]
面向病理学家的人工智能：一种通用的淋巴结转移检测应用程序，可在提高效率的同时保持诊断准确性
Jennifer Vazzano,Bindu Challa,Vidya Arole et al.
Jennifer Vazzano et al.
Increasing workload combined with the shortage of pathologists is the leading cause of diagnostic errors and delays. Nonetheless, in clinical practice, pathologists often spend hours on tedious tasks such as counting mitoses and searching f...
Alcian blue-positive stromal phenotype in basal cell carcinoma is associated with progression on first-line hedgehog inhibitors [0.03%]
巴克霍夫蓝色染色阳性基底细胞癌间质表型与一线 Hedgehog 途径抑制剂治疗失败相关
Viola K DeTemple,Rudolf Stadler,Sabine Bredemeier et al.
Viola K DeTemple et al.
Basal cell carcinoma (BCC) is the most frequent malignancy in fair-skinned populations. Although curable in most cases, approximately 4% of patients develop locally advanced or metastatic disease (advBCC) requiring systemic therapy. Hedgeho...
Assessing the association between homologous recombination deficiency scores and treatment response in localized and metastatic prostate cancer [0.03%]
评估同源重组缺陷评分与局部和转移性前列腺癌治疗反应之间的关联
Qiyu Zhu,Yifu Shi,Ting Wang et al.
Qiyu Zhu et al.
The aim of this study was to evaluate the predictive value of homologous recombination deficiency scores for therapeutic efficacy in prostate cancer across various disease stages under different regimens. We collected tissue samples from 16...
Prognostic significance of beta-adrenergic receptor expression in oesophageal adenocarcinoma [0.03%]
β肾上腺素能受体在食管腺癌中的预后意义
Talita Oliveira,Swathi Sasi,James Trainor et al.
Talita Oliveira et al.
Expression of the β-adrenergic receptors' family has been associated with survival outcomes in multiple different cancer types, showing their potential to act as prognostic factors. No previous work has evaluated these receptors in relatio...
Diagnostic utility and pitfalls of human T-lymphotropic virus serology in adult T-cell leukemia/lymphoma: evidence from a 25-year pathology-based nonendemic cohort [0.03%]
成人T细胞白血病/淋巴瘤人类T细胞淋巴病毒血清学诊断的实用性和陷阱：一项基于病理学的非流行地区队列25年证据分析
Chang-Tsu Yuan,Li-Yu Sun,Shih-Sung Chuang et al.
Chang-Tsu Yuan et al.
Adult T-cell leukemia/lymphoma (ATLL) is a distinct type of peripheral T-cell lymphoma (PTCL) driven by human T-lymphotropic virus type I (HTLV-1)-infected T cells, but diagnosis can be confounded by histological overlap with non-ATLL PTCL....
Implementing Immunoscore in colorectal cancer: lessons from cohort studies, limitations and barriers to adoption [0.03%]
结直肠癌中实施免疫评分：队列研究中的经验、局限性和障碍
Matthew Ss Hsu,Suet Yi Leung
Matthew Ss Hsu
The Immunoscore (IS) quantifies the immune contexture of colorectal cancer (CRC) by measuring CD3+ and CD8+ T-cell densities in the tumour centre and invasive margin, providing superior prognostic performance compared with TNM staging and m...
Validation of fibroblast activation protein and α-smooth muscle actin as prognostic biomarkers in prostate cancer through AI-assisted image analysis of dual-marker IHC [0.03%]
通过人工智能辅助的双标记免疫组化图像分析验证成纤维细胞活化蛋白和α-平滑肌肌动蛋白作为前列腺癌预后生物标志物的有效性
Jenni Säilä,Timo-Pekka Lehto,Antti Rannikko et al.
Jenni Säilä et al.
Prostate cancer (PCa) lacks reliable and accurate tissue-based biomarkers to support prognostic stratification and clinical treatment decisions. Current diagnostic assessment, including Gleason grading, has limitations such as interobserver...
Systemic and local decorin levels mirror the clinical course of pancreatic cancer [0.03%]
系统性和局部Decorin水平反映了胰腺癌的临床病程
Maja Svensson,Sophie Lehn,Hedda Jacobsen et al.
Maja Svensson et al.
Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine-rich ...
Observational Study
The journal of pathology. Clinical research. 2026 Jan;12(1):e70066. DOI:10.1002/2056-4538.70066 2026