Molecular subtype concordance and metastatic patterns in muscle-invasive bladder cancer [0.03%]
肌浸润性膀胱癌的分子亚型一致性及转移模式
Csilla Olah,Dániel Juhász,Melinda Váradi et al.
Csilla Olah et al.
Molecular subtypes are potential prognostic and predictive tools in muscle-invasive bladder cancer (MIBC). However, subtype concordance between primary tumors and metastases, as well as subtype-specific differences in metastatic patterns, r...
ATM immunohistochemistry as an effective screening method for POLE variants among endometrial carcinomas lacking mismatch repair deficiency and p53 abnormalities [0.03%]
ATM免疫组化在缺乏错配修复缺陷和P53异常的子宫内膜癌中的POLE变异有效筛查方法
Xinyi Huang,Yingmei Wang,Wenjing Ni et al.
Xinyi Huang et al.
The molecular classification of endometrial carcinomas (ECs) is now integrated into clinical practice. However, identification of polymerase-ε (POLE) variants remains reliant on DNA sequencing, which limits broader implementation. Given th...
Folate receptor alpha (FRα) expression in tubo-ovarian and endometrial tumors: a study of 923 cases [0.03%]
输卵管和卵巢肿瘤及子宫内膜肿瘤中叶酸受体alpha(FRα)的表达：923例病例研究
Isabela Töltési,Kristýna Němejcová,Michaela Kendall Bártů et al.
Isabela Töltési et al.
Folate receptor alpha (FRα) is a promising therapeutic target due to its high expression in several tumor types and its rare expression in healthy tissue. Recently, the antibody-drug conjugate mirvetuximab soravtansine has been approved fo...
Weakly supervised deep learning for cutaneous squamous and basal cell carcinoma in whole-slide histopathology [0.03%]
弱监督深度学习在整张病理切片图像中区分皮肤鳞状细胞癌和基底细胞癌
Anne Petzold,Anja Wessely,Stefan Schliep et al.
Anne Petzold et al.
Distinguishing infiltrative basal cell carcinoma (BCC) from poorly differentiated cutaneous squamous cell carcinoma (cSCC) remains a significant histopathological challenge. Automated deep learning approaches hold promise for improving diag...
Spatial heterogeneity of antibody-drug conjugate targets in pancreatic ductal adenocarcinoma [0.03%]
胰腺导管腺癌中抗体偶联药物靶点的空间异质性
Deema Sabtan,Marie-Lisa Eich,Florian Loch et al.
Deema Sabtan et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, with limited therapeutic options, few patients showing targetable molecular changes. New therapeutic strategies are necessary. Antibody-drug conjugates (ADCs) have emerged as alte...
Clinicopathologic and molecular landscape of villitis of unknown etiology: insights from a large-scale case-control study in PR China [0.03%]
中国大规模病例对照研究揭示胎盘绒毛发炎的临床病理和分子特征
Meiling Wang,Xiaorong Sun,Huayan Ren et al.
Meiling Wang et al.
Villitis of unknown etiology (VUE) is a chronic placental inflammatory lesion characterized by lymphohistiocytic infiltration and destruction of villous architecture in the absence of infection. Although VUE is well recognized for its assoc...
Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study [0.03%]
NPM1突变、单核细胞来源以及器官和系统受累的预后意义在粒细胞肉瘤中的研究：一项多中心研究
Alex Jenei,Béla Kajtár,Tamás László et al.
Alex Jenei et al.
Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, e...
AI-derived prognostic biomarkers from melanoma whole slide image segmentation: an initial discovery and assessment [0.03%]
基于黑色素瘤整片图像分割的AI衍生预后生物标志物的研究与评估
Emily L Clarke,Derek Magee,Julia Newton-Bishop et al.
Emily L Clarke et al.
The current melanoma staging system predicts 74% of the variance in survival, with prognostic biomarkers subject to high levels of inter-observer variation. This work assesses whether a previously developed convolutional neural network (CNN...
Preservation of cell-free RNA in percutaneous core-needle biopsy specimens' supernatants from non-small cell lung cancer improves genomic testing performance [0.03%]
保存非小细胞肺癌经皮空心针穿刺活检标本上清液中的无细胞RNA可提高基因组检测性能
Sheng Xu,Yi-Dan Ma,Zhi-Xin Bie et al.
Sheng Xu et al.
This prospective single-center study aimed to investigate whether preserving cell-free ribonucleic acid (cfRNA) in specimens' supernatants (SS) obtained from percutaneous core-needle biopsy (CNB) of non-small cell lung cancer (NSCLC) can im...
Impact of tissue staining and scanner variation on the performance of pathology foundation models: a study of sarcomas and their mimics [0.03%]
组织染色和扫描器差异对病理基础模型性能的影响：一种关于肉瘤及其类似病变的研究方法
Binghao Chai,Jianan Chen,Paul Cool et al.
Binghao Chai et al.
Histopathological analysis is considered the gold standard for the diagnosis and prognostication of cancer. Recent advances in AI, driven by large-scale digitisation and pan-cancer foundation models, are opening new opportunities for clinic...