Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle-invasive bladder cancer [0.03%]
肌侵袭性膀胱癌中CD39和CD73表达水平独立且相反地预示生存率
Stephan Ledderose,Julia Schwenke,Lennert Eismann et al.
Stephan Ledderose et al.
Bladder cancer is one of the leading causes of cancer-related mortality worldwide. Long-term survival is particularly poor in patients with muscle-invasive bladder cancer (MIBC). Modulation of purinergic signaling through the ectonucleotida...
Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer [0.03%]
雌激素受体磷酸化谱和基于PAM50的计算分类可反映乳腺癌的性别二元性特征
Subarnarekha Chatterji,Aimee Diack,Marcin Szostok et al.
Subarnarekha Chatterji et al.
Breast cancer (BC) is most prevalent in females but also accounts for
Clinicopathological and molecular characterization of HPV-associated cervical poorly cohesive carcinoma: a rare aggressive entity [0.03%]
与HPV相关的宫颈低黏附性癌的临床病理和分子特征：一种罕见的侵袭性肿瘤实体
Wei Liu,Xiao-Jiang Wang,Yan-Mei Cui et al.
Wei Liu et al.
Primary signet-ring cell carcinoma and poorly differentiated adenocarcinoma with poorly cohesive morphology in the cervix are rare conditions, and their clinicopathological features remain poorly described. This study defines primary cervic...
YAP-activated lymph node fibroblasts contribute to extracellular matrix remodeling associated with extranodal extension of oral squamous cell carcinoma [0.03%]
YAP激活的淋巴结成纤维细胞参与头颈部鳞癌淋巴结转移灶外侵相关的细胞外基质重塑
Qian Zhang,Shanben Jiang,Ansardin Abliz et al.
Qian Zhang et al.
Desmoplasia, characterized by excessive expansion of cancer-associated fibroblasts (CAFs) and aberrant extracellular matrix (ECM) deposition, is widely present especially in invasive cancers. The extranodal extension (ENE) of nodal metastas...
A subset of high-grade sarcomas with myogenic differentiation are associated with recurrent FGFR fusions [0.03%]
部分横纹肌肉瘤伴有FGFR融合的高分化的肉瘤亚型
Maximus Cf Yeung,Carla Saoud,Sarah Chiang et al.
Maximus Cf Yeung et al.
Recurrent fusions involving FGFR1-4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with...
Do all colorectal mucinous adenocarcinomas arise via the serrated neoplasia pathway? [0.03%]
并非所有的结直肠黏液腺癌都起源于锯齿状息肉病途径吗？
Anne-Marie Vos,Peter H van Zwam,Natasja Rutgers et al.
Anne-Marie Vos et al.
Colorectal mucinous adenocarcinomas (MACs) and serrated adenocarcinomas (SACs) demonstrate considerable overlap in morphological and molecular features, suggesting a spectrum rather than two distinct tumour types. This study investigates th...
The prognostic significance of the IASLC grading system in ALK-positive invasive non-mucinous adenocarcinoma of the lung: correlation with clinicopathological features [0.03%]
I型腺癌中IASLC分级系统预后的意义及其与临床病理特征的关系：肺癌ALK阳性患者的分析
Dongmei Gu,Jie Bao,Hong Chen et al.
Dongmei Gu et al.
The prognostic value of the International Association for the Study of Lung Cancer (IASLC) grading system in anaplastic lymphoma kinase (ALK)-positive invasive non-mucinous adenocarcinoma (INMA) remains unclear, particularly in relation to ...
Reduced folate receptor alpha (FOLR1) protein expression in fallopian tubes from premenopausal women: implications for the FOLR1 CDx assay for mirvetuximab-soravtansine therapy [0.03%]
绝经前女性输卵管中叶酸受体α（FOLR1）蛋白表达：mirvetuximab soravtansine治疗FOLR1伴随检测的含义
Annika Nasdala,Leonie D Kandt,Martin Radner et al.
Annika Nasdala et al.
Mirvetuximab-soravtansine (MIRV-S) is an antibody-drug conjugate targeting folate receptor alpha (FOLR1). MIRV-S is approved for the treatment of FOLR1-positive, platinum-resistant ovarian carcinoma. Patient eligibility is determined by imm...
Katherine J Hewitt,Nic G Reitsam,Sebastian Foersch et al.
Katherine J Hewitt et al.
The application of artificial intelligence in computational pathology depends on both robust algorithms and high-quality, clinically reliable data. Progress in this field has been limited by the scarcity of large, diverse, and well-validate...
MET fusions and splicing variants in glioma: a landscape integrating clinical, pathological, and survival features [0.03%]
胶质瘤中的MET融合和拼接变异：整合临床、病理和生存特征的图谱分析
Zheng Fang,Chengjun Zheng,Peng Wang et al.
Zheng Fang et al.
MET alterations, including MET fusions and splicing variants (F/SVs), are linked to glioma progression, but the clinical features remain underexplored since the 2021 WHO classification of tumors of the CNS. We aimed to systematically depict...