Subtype-associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms [0.03%]
胰腺肿瘤中与亚型相关的NLRP3炎性小体景观的复杂性和预后意义
Kristóf Németh,Eszter Mezei,Justína Vörös et al.
Kristóf Németh et al.
Intraductal papillary mucinous neoplasm (IPMN) can progress into malignant pancreatic cancer, posing challenges in accurately assessing the risk of malignancy. While the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin do...
Platinum drugs upregulate CXCR4 and PD-L1 expression via ROS-dependent pathways, with implications for novel combined treatment in gastric cancer [0.03%]
铂类药物通过依赖ROS的途径上调胃癌中CXCR4和PD-L1表达并对其联合治疗具有潜在影响
Xiaoyu Kang,Lin Zhang,Shushang Liu et al.
Xiaoyu Kang et al.
CXC chemokine receptor 4 (CXCR4) and programmed cell death-ligand 1 (PD-L1) are two critical molecules involved in the tumor immune microenvironment. However, the impact of platinum drugs, such as cisplatin, on CXCR4 or PD-L1 expression and...
Authors' reply: Re: Koga et al. Retrieval-augmented generation versus document-grounded generation: a key distinction in large language models [0.03%]
作者回复：关于小川等人的评论：“检索增强生成与文档基础生成：大型语言模型中的关键区别”
Katherine J Hewitt,Isabella C Wiest,Jakob N Kather
Katherine J Hewitt
Retrieval-augmented generation versus document-grounded generation: a key distinction in large language models [0.03%]
检索增强生成与基于文档的生成：大型语言模型中的关键区别
Shunsuke Koga,Daisuke Ono,Amrom Obstfeld
Shunsuke Koga
Immunohistochemistry-based molecular subtypes of urothelial carcinoma derive different survival benefit from platinum chemotherapy [0.03%]
基于免疫组化的膀胱尿路上皮癌分子分型指导铂类化疗预后预测价值研究
Csilla Olah,Oleksandr Shmorhun,Gilbert Georg Klamminger et al.
Csilla Olah et al.
Distinct molecular subtypes of muscle-invasive bladder cancer (MIBC) may show different platinum sensitivities. Currently available data were mostly generated at transcriptome level and have limited comparability to each other. We aimed to ...
Loss of MTAP expression is strongly linked to homozygous 9p21 deletion, unfavorable tumor phenotype, and noninflamed microenvironment in urothelial bladder cancer [0.03%]
MTAP表达缺失与同源9p21基因座缺失及不利肿瘤表型和非炎症微环境显著相关：一项关于尿路上皮癌的研究
Natalia Gorbokon,Niklas Wößner,Viktoria Ahlburg et al.
Natalia Gorbokon et al.
Homozygous 9p21 deletions usually result in a complete loss of S-methyl-5'-thioadenosine phosphorylase (MTAP) expression visualizable by immunohistochemistry (IHC). MTAP deficiency has been proposed as a marker for predicting targeted treat...
Large multimodal model-based standardisation of pathology reports with confidence and its prognostic significance [0.03%]
基于大型多模态模型的病理报告标准化及其预后意义
Ethar Alzaid,Gabriele Pergola,Harriet Evans et al.
Ethar Alzaid et al.
Despite the existence of established standards and guidelines for pathology reporting, many pathology reports are still written in unstructured free text. Extracting information from these reports and formatting it according to a standard i...
High chromosomal instability is associated with higher 10-year risks of recurrence for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer patients: clinical evidence from a large-scale, multiple-site, retrospective study [0.03%]
高染色体不稳定与激素受体阳性人表皮生长因子受体2阴性乳腺癌患者的10年复发风险增加相关：大型多中心回顾性研究的临床证据
Yu-Yang Liao,Jianfei Fu,Xiang Lu et al.
Yu-Yang Liao et al.
Long-term survival varies among hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer patients and is seriously impaired by metastasis. Chromosomal instability (CIN) was one of the key d...
Clinicopathological and epigenetic differences between primary neuroendocrine tumors and neuroendocrine metastases in the ovary [0.03%]
卵巢原发神经内分泌肿瘤与转移性神经内分泌肿瘤的临床病理及表观遗传学差异
Merijn Cf Mulders,Anna Vera D Verschuur,Quido G de Lussanet de la Sablonière et al.
Merijn Cf Mulders et al.
Currently, the available literature provides insufficient support to differentiate between primary ovarian neuroendocrine tumors (PON) and neuroendocrine ovarian metastases (NOM) in patients. For this reason, patients with a well-differenti...
Katherine J Hewitt,Isabella C Wiest,Zunamys I Carrero et al.
Katherine J Hewitt et al.
The WHO guidelines for classifying central nervous system (CNS) tumours are changing considerably with each release. The classification of CNS tumours is uniquely complex among most other solid tumours as it incorporates not just morphology...