Time distortions in Alzheimer's disease: a systematic review and theoretical integration [0.03%]
阿尔茨海默病的时间扭曲：系统回顾及理论整合
Mohamad El Haj,Dimitrios Kapogiannis
Mohamad El Haj
Time perception is an essential function of the human brain, which is compromised in Alzheimer's disease (AD). Here, we review empirical findings on time distortions in AD and provide a theoretical framework that integrates time and memory ...
Inge Seim,Siming Ma,Vadim N Gladyshev
Inge Seim
Different cell types within the body exhibit substantial variation in the average time they live, ranging from days to the lifetime of the organism. The underlying mechanisms governing the diverse lifespan of different cell types are not we...
Kazuo Tsubota
Kazuo Tsubota
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids [0.03%]
阿米洛伊德蛋白毒性引发的炎症反应可被大麻中的活性成分阻断
Antonio Currais,Oswald Quehenberger,Aaron M Armando et al.
Antonio Currais et al.
The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well unde...
Masaharu Uno,Eisuke Nishida
Masaharu Uno
The molecular mechanisms underlying the aging process have garnered much attention in recent decades because aging is the most significant risk factor for many chronic diseases such as type 2 diabetes and cancer. Until recently, the aging p...
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism [0.03%]
分子氢刺激转录共激活因子PGC-1α的基因表达以增强脂肪酸代谢
Naomi Kamimura,Harumi Ichimiya,Katsuya Iuchi et al.
Naomi Kamimura et al.
We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibit multiple functions. Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in d...
Cytochrome b5 reductase and the control of lipid metabolism and healthspan [0.03%]
细胞色素b5还原酶与脂质代谢和健康寿命的调控
Alejandro Martin-Montalvo,Yaning Sun,Alberto Diaz-Ruiz et al.
Alejandro Martin-Montalvo et al.
Cytochrome b5 reductases (CYB5R) are required for the elongation and desaturation of fatty acids, cholesterol synthesis and mono-oxygenation of cytochrome P450 enzymes, all of which are associated with protection against metabolic disorders...
Yeast longevity promoted by reversing aging-associated decline in heavy isotope content [0.03%]
由逆转衰老引起的同位素含量下降所促进的酵母寿命延长
Xiyan Li,Michael P Snyder
Xiyan Li
Dysregulation of metabolism develops with organismal aging. Both genetic and environmental manipulations promote longevity by effectively diverting various metabolic processes against aging. How these processes converge on the metabolome is...
Jonathan B Lin,Kazuo Tsubota,Rajendra S Apte
Jonathan B Lin
Extensive investigations have demonstrated that organismal aging is associated with tissue dysfunction in many organs. The eye is no exception to this rule. Under healthy conditions, the eye is designed like an advanced camera with the cent...
Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation [0.03%]
异时性微小RNA在神经干细胞时间特化中的作用：应用于细胞年轻化
Takuya Shimazaki,Hideyuki Okano
Takuya Shimazaki
Plasticity is a critical factor enabling stem cells to contribute to the development and regeneration of tissues. In the mammalian central nervous system (CNS), neural stem cells (NSCs) that are defined by their capability for self-renewal ...