SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes [0.03%]
SMARCD1调节肝细胞衰老相关的脂质积累
Chisato Inoue,Chong Zhao,Yumi Tsuduki et al.
Chisato Inoue et al.
Previously, we have identified 16 senescence-associated genes by a subtractive proteomic analysis using presenescent and senescent human fibroblast cells, TIG-1. The aim of this study was to clarify the role of SMARCD1, one of the identifie...
Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation [0.03%]
外周时钟调控交感功能障碍导致的年龄相关昼夜节律紊乱
Yu Tahara,Yuta Takatsu,Takuya Shiraishi et al.
Yu Tahara et al.
The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. To date, little is known about age-related changes in the entra...
Hsa-miR-520d-5p promotes survival in human dermal fibroblasts exposed to a lethal dose of UV irradiation [0.03%]
微RNA hsa-miR-520d-5p通过抑制PDCD4促进人类皮肤成纤维细胞生存应对致死剂量的紫外线照射
Yoshitaka Ishihara,Satoshi Tsuno,Bingqiong Ping et al.
Yoshitaka Ishihara et al.
We previously reported that hsa-miR-520d-5p is functionally involved in the induction of the epithelial-mesenchymal transition and stemness-mediated processes in normal cells and cancer cells, respectively. On the basis of the synergistic e...
The oxidation state of the cytoplasmic glutathione redox system does not correlate with replicative lifespan in yeast [0.03%]
细胞质谷胱甘肽氧化还原系统的状态与酵母复制寿命无关
Robert A Knieß,Matthias P Mayer
Robert A Knieß
What is cause and what is consequence of aging and whether reactive oxygen species (ROS) contribute to this phenomenon is debated since more than 50 years. Notwithstanding, little is known about the cellular buffer and redox systems in agin...
Metformin decreases progerin expression and alleviates pathological defects of Hutchinson-Gilford progeria syndrome cells [0.03%]
二甲双胍降低早衰细胞中原纤维肌动蛋白表达并改善早衰症细胞的病理缺陷
Anne-Laure Egesipe,Sophie Blondel,Alessandra Lo Cicero et al.
Anne-Laure Egesipe et al.
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that causes systemic accelerated aging in children. This syndrome is due to a mutation in the LMNA gene that leads to the production of a truncated and toxic form of lam...
Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive function [0.03%]
血管紧张素转换酶2缺乏导致认知功能障碍恶化
Xiao-Li Wang,Jun Iwanami,Li-Juan Min et al.
Xiao-Li Wang et al.
The classical renin-angiotensin system (RAS), known as the angiotensin (Ang)-converting enzyme (ACE)/Ang II/Ang II type 1 (AT1) receptor axis, induces various organ damages including cognitive decline. On the other hand, the ACE2/Ang-(1-7)/...
Increased oxidative phosphorylation in response to acute and chronic DNA damage [0.03%]
急性与慢性DNA损伤后线粒体氧化磷酸化的增强
Lear E Brace,Sarah C Vose,Kristopher Stanya et al.
Lear E Brace et al.
Accumulation of DNA damage is intricately linked to aging, aging-related diseases and progeroid syndromes such as Cockayne syndrome (CS). Free radicals from endogenous oxidative energy metabolism can damage DNA, however the potential of acu...
Kazuo Tsubota
Kazuo Tsubota
Yumiko Oishi,Ichiro Manabe
Yumiko Oishi
Chronic inflammation is the common pathological basis for such age-associated diseases as cardiovascular disease, diabetes, cancer and Alzheimer's disease. A multitude of bodily changes occur with aging that contribute to the initiation and...
It takes two to tango: NAD+ and sirtuins in aging/longevity control [0.03%]
尼古丁转运蛋白家族成员在植物和动物中的功能分化及相互作用机制研究进展
Shin-Ichiro Imai,Leonard Guarente
Shin-Ichiro Imai
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called 'sirtuins.' This intimate connection between NAD+ and sirtuins has an ancient origin and provide...