Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging [0.03%]
应对千变万化的敌人：免疫衰老、疫苗和健康老龄化
Giuseppe Del Giudice,Jörg J Goronzy,Beatrix Grubeck-Loebenstein et al.
Giuseppe Del Giudice et al.
The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect older adults is one pivotal in...
Neuroprotective role of retinal SIRT3 against acute photo-stress [0.03%]
视网膜SIRT3的神经保护作用对抗急性光压力损伤中的作用
Norimitsu Ban,Yoko Ozawa,Hideto Osada et al.
Norimitsu Ban et al.
SIRT3 is a key regulator of mitochondrial reactive oxygen species as well as mitochondrial function. The retina is one of the highest energy-demanding tissues, in which the regulation of reactive oxygen species is critical to prevent retina...
Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration [0.03%]
细胞色素b5通过保护视杆细胞免受光照诱导的脂质过氧化来预防视网膜变性
Xinping Chen,Hana Hall,Jeffrey P Simpson et al.
Xinping Chen et al.
Lipid peroxides are generated by oxidative stress in cells, and contribute to ageing and neurodegenerative disease. The eye is at special risk for lipid peroxidation because photoreceptors possess amplified sensory membranes rich in peroxid...
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study [0.03%]
随机双盲安慰剂对照试验：NRPT（烟酰胺核糖和pterostilbene）重复给药可安全且持续地提高人体内NAD+水平
Ryan W Dellinger,Santiago Roel Santos,Mark Morris et al.
Ryan W Dellinger et al.
NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD+) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial ...
Health benefits of late-onset metformin treatment every other week in mice [0.03%]
隔周一次晚发 metformin 处理的小鼠的健康益处
Irene Alfaras,Sarah J Mitchell,Hector Mora et al.
Irene Alfaras et al.
Chronic 1% metformin treatment is nephrotoxic in mice, but this dose may nonetheless confer health benefits if given intermittently rather than continuously. Here, we examined the effects of 1% metformin given every-other week (EOW) or two ...
Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice [0.03%]
由细菌感染引起的牙周炎会加剧转基因小鼠阿尔茨海默病的症状
Naoyuki Ishida,Yuichi Ishihara,Kazuto Ishida et al.
Naoyuki Ishida et al.
Periodontitis is a localized infectious disease caused by periodontopathic bacteria, such as Porphyromonas gingivalis. Recently, it has been suggested that bacterial infections may contribute to the onset and the progression of Alzheimer's ...
Erratum: Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span [0.03%]
DNA修复因子dPrp19的泛表达延长果蝇寿命并减少DNA损伤——刊载于2013年7月《美国科学院院报》的论文的勘误
Kathrin Garschall,Hanna Dellago,Martina Gáliková et al.
Kathrin Garschall et al.
[This corrects the article DOI: 10.1038/s41514-017-0005-z.].
Published Erratum
NPJ aging and mechanisms of disease. 2017 Aug 15:3:10. DOI:10.1038/s41514-017-0008-9 2017
Andrzej Bartke
Andrzej Bartke
Although larger species of animals typically live longer than smaller species, the relationship of body size to longevity within a species is generally opposite. The longevity advantage of smaller individuals can be considerable and is best...
Edward J Calabrese,Mark P Mattson
Edward J Calabrese
Hormesis refers to adaptive responses of biological systems to moderate environmental or self-imposed challenges through which the system improves its functionality and/or tolerance to more severe challenges. The past two decades have witne...
Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality [0.03%]
用SGLT2抑制剂TA-1887治疗糖尿病小鼠可以对抗糖尿病恶病质并降低死亡率
Taichi Sugizaki,Shunshun Zhu,Ge Guo et al.
Taichi Sugizaki et al.
A favorable effect of an inhibitor of the sodium-glucose cotransporter 2 (SGLT2i) on mortality of diabetic patients was recently reported, although mechanisms underlying that effect remained unclear. Here, we examine SGLT2i effects on survi...