ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells [0.03%]
与衰老细胞中干扰素诱导基因组成型表达相关的是具有较低磷酸化的ISGF3
Mari Yamagami,Motoyuki Otsuka,Takahiro Kishikawa et al.
Mari Yamagami et al.
During cellular aging, many changes in cellular functions occur. A hallmark of aged cells is secretion of inflammatory mediators, which collectively is referred to as the senescence-associated secretory phenotype (SASP). However, the mechan...
CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves [0.03%]
CA1神经元特异性Nampt敲低重现老化小鼠海马认知表型并用NMN改善
Sean Johnson,David F Wozniak,S Imai
Sean Johnson
Cognitive dysfunction is one of the most concerning outcomes in global population aging. However, the mechanisms by which cognitive functions are impaired during aging remain elusive. It has been established that NAD+ levels are reduced in ...
Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4 [0.03%]
通过限制G蛋白偶联受体CXCR4的上调和激活来控制衰老和抗癌治疗中的炎症反应
Raji R Nair,Shreyas V Madiwale,Deepak Kumar Saini
Raji R Nair
One of the major pathological outcomes of DNA damage during aging or anticancer therapy is enhanced inflammation. However, the underlying signaling mechanism that drives this is not well understood. Here, we show that in response to DNA dam...
Erratum: Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study [0.03%]
校正：重复给药NRPT（烟酰胺核糖和pterostilbene）可安全而持续地提高人体NAD +水平：随机，双盲，安慰剂对照试验
Ryan W Dellinger,Santiago Roel Santos,Mark Morris et al.
Ryan W Dellinger et al.
[This corrects the article DOI: 10.1038/s41514-017-0016-9.].
Published Erratum
NPJ aging and mechanisms of disease. 2018 Aug 20:4:8. DOI:10.1038/s41514-018-0027-1 2018
The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy [0.03%]
PCSK9抑制剂与他汀类药物联合治疗的冠状动脉钙化年增长率低于单用他汀类药物治疗
Yuichi Ikegami,Ikuo Inoue,Kaiji Inoue et al.
Yuichi Ikegami et al.
Statins and/or PCSK9 inhibitors cause the regression of coronary atheroma and reduce clinical events. However, it currently remains unclear whether these drugs modulate coronary atheroma calcification in vivo. Coronary artery calcium (CAC) ...
A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans [0.03%]
一种类似孤雌生殖的非正常程序可导致秀丽隐杆线虫在衰老过程中形成畸胎类肿瘤
Hongyuan Wang,Yuan Zhao,Marina Ezcurra et al.
Hongyuan Wang et al.
A long-standing belief is that aging (senescence) is the result of stochastic damage accumulation. Alternatively, senescent pathology may also result from late-life, wild-type gene action (i.e., antagonistic pleiotropy, as argued by William...
Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction [0.03%]
组织特异性转录组分析揭示了果蝇限制饮食条件下GATA转录因子的长寿作用
Adam J Dobson,Xiaoli He,Eric Blanc et al.
Adam J Dobson et al.
Dietary restriction (DR) extends animal lifespan, but imposes fitness costs. This phenomenon depends on dietary essential amino acids (EAAs) and TOR signalling, which exert systemic effects. However, the roles of specific tissues and cell-a...
Blocking negative effects of senescence in human skin fibroblasts with a plant extract [0.03%]
植物提取物可防止人皮肤纤维母细胞衰老的负面影响
Ingo Lämmermann,Lucia Terlecki-Zaniewicz,Regina Weinmüllner et al.
Ingo Lämmermann et al.
There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding t...
Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control [0.03%]
酿酒酵母种群的生理老化自然变异揭示了饮食依赖性的寿命控制机制
Paul P Jung,Zhi Zhang,Nicole Paczia et al.
Paul P Jung et al.
Aging is a complex trait of broad scientific interest, especially because of its intrinsic link with common human diseases. Pioneering work on aging-related mechanisms has been made in Saccharomyces cerevisiae, mainly through the use of del...
Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial [0.03%]
从发现到随机、双盲、安慰剂对照试验的SR-0379功能性肽治疗肢体溃疡的医师发起型临床研究
Hironori Nakagami,Ken Sugimoto,Takahiro Ishikawa et al.
Hironori Nakagami et al.
SR-0379 is a functional peptide that has wound healing effect with anti-microbial action, making it an ideal drug to prevent infection. To evaluate the safety, efficacy, and pharmacokinetics of SR-0379 for the treatment of leg ulcers, a phy...