Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration [0.03%]
年龄相关性黄斑变性假定通路和蛋白质-蛋白质相互作用网络的存储库
Fran M Pool,Christina Kiel,Luis Serrano et al.
Fran M Pool et al.
Age-related macular degeneration (AMD) is one of the commonest causes of sight loss in the elderly population and to date there is no intervention that slows or prevents early AMD disease progressing to blinding neovascularization or geogra...
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome [0.03%]
短期补充烟酰胺腺嘌呤二核苷酸可预防小头细胞性角化病模型小鼠听力下降
Mustafa N Okur,Beatrice Mao,Risako Kimura et al.
Mustafa N Okur et al.
Age-related hearing loss (ARHL) is one of the most common disorders affecting elderly individuals. There is an urgent need for effective preventive measures for ARHL because none are currently available. Cockayne syndrome (CS) is a prematur...
Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila [0.03%]
蓝光暴露可缩短果蝇寿命并导致神经元退化
Trevor R Nash,Eileen S Chow,Alexander D Law et al.
Trevor R Nash et al.
Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can inte...
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy [0.03%]
抗衰老药物 nordihydroguaiaretic acid 抑制 p300 和激活自噬作用
Tugsan Tezil,Manish Chamoli,Che-Ping Ng et al.
Tugsan Tezil et al.
Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules. The natural compound nordihydrogua...
Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system [0.03%]
RU486和GeneSwitch系统通过组织特异性改变基因表达和功能来诱导疾病模型中的治疗性基因沉默
Maricela Robles-Murguia,Liam C Hunt,David Finkelstein et al.
Maricela Robles-Murguia et al.
The GeneSwitch (GS) is a modified Gal4/UAS system, whereby transgene expression is induced in Drosophila by adding the drug RU486 to food. The GS system is routinely used in Drosophila aging and behavioral studies to avoid confounding effec...
Erratum: Publisher Correction: Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging [0.03%]
表观沉默Lgr5诱导肠上皮类器官在衰老过程中的衰老 Erratum
Ryoei Uchida,Yoshimasa Saito,Kazuki Nogami et al.
Ryoei Uchida et al.
[This corrects the article DOI: 10.1038/s41514-018-0031-5.].
Published Erratum
NPJ aging and mechanisms of disease. 2019 Mar 7:5:5. DOI:10.1038/s41514-019-0035-9 2019
Ilja L Kruglikov,Philipp E Scherer
Ilja L Kruglikov
Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psori...
Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer's disease [0.03%]
职业性有机磷暴露扰乱小胶质细胞并加速阿尔茨海默病大鼠模型的病变发展
Jaymie R Voorhees,Matthew T Remy,Claire M Erickson et al.
Jaymie R Voorhees et al.
Occupational exposure to organophosphate pesticides, such as chlorpyrifos (CPF), increases the risk of Alzheimer's disease (AD), though the mechanism is unclear. To investigate this, we subjected 4-month-old male and female wild-type (WT) a...
New drugs for pharmacological extension of replicative life span in normal and progeroid cells [0.03%]
可延缓正常及早衰细胞复制衰老的新型药物
Sergei Vatolin,Tomas Radivoyevitch,Jaroslaw P Maciejewski
Sergei Vatolin
A high-throughput anti-aging drug screen was developed that simultaneously measures senescence-associated β-galactosidase activity and proliferation. Applied to replicatively pre-aged fibroblasts, this screen yielded violuric acid (VA) and...
Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging [0.03%]
表观遗传沉默Lgr5会在衰老过程中诱导肠道上皮类器官发生衰老现象
Ryoei Uchida,Yoshimasa Saito,Kazuki Nogami et al.
Ryoei Uchida et al.
To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice and investigated alterations in their senescence and epigenetic status. Senescence-related...