Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system [0.03%]
糖尿病氧化应激的分子分型的即时护理核磁系统
Weng Kung Peng,Lan Chen,Bernhard O Boehm et al.
Weng Kung Peng et al.
Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new appro...
Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system [0.03%]
糖尿病氧化应激的分子分型的即时护理核磁系统应用查看
Weng Kung Peng,Lan Chen,Bernhard O Boehm et al.
Weng Kung Peng et al.
Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new appro...
Targeting of intracellular Ca2+ stores as a therapeutic strategy against age-related neurotoxicities [0.03%]
靶向细胞内钙池作为对抗年龄相关神经毒性的治疗策略
Joshua Goldberg,Antonio Currais,Gamze Ates et al.
Joshua Goldberg et al.
Calcium dysregulation often underlies pathologies associated with aging and age-associated neurodegenerative diseases. Cells express a unique pattern of Ca2+ channels and pumps geared to fulfill specific physiological requirements and there...
Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice [0.03%]
短期热量限制可提高小鼠的非同源末端连接DNA修复能力
Zhonghe Ke,Denis Firsanov,Brianna Spencer et al.
Zhonghe Ke et al.
Calorie restriction (CR) improves health, reduces cancer incidence and extends lifespan in multiple organisms including mice. CR was shown to enhance base excision repair and nucleotide excision repair pathways of DNA repair, however, wheth...
Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome [0.03%]
揭露二硫脲保护机体免受肥胖和代谢综合征侵害的机制
Michel Bernier,Dylan Harney,Yen Chin Koay et al.
Michel Bernier et al.
There is an unmet need and urgency to find safe and effective anti-obesity interventions. Our recent study in mice fed on obesogenic diet found that treatment with the alcohol aversive drug disulfiram reduced feeding efficiency and led to a...
Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice [0.03%]
合成大麻素CP55940在C57BL/6小鼠中的年龄依赖性激素类似效应
Erik L Hodges,Jessica P Marshall,Nicole M Ashpole
Erik L Hodges
Use of cannabis and cannabinoid-containing substances is increasing among geriatric patients, despite relatively sparse preclinical evidence in aged models. To better understand the effects of exogenous cannabinoids on aging male and female...
Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation [0.03%]
外源H2S对秀丽隐杆线虫的寿命和健康期的影响独立于eat-2突变下游效应的作用
Li Theng Ng,Li Fang Ng,Richard Ming Yi Tang et al.
Li Theng Ng et al.
Caloric restriction (CR) is one of the most effective interventions to prolong lifespan and promote health. Recently, it has been suggested that hydrogen sulfide (H2S) may play a pivotal role in mediating some of these CR-associated benefit...
Alexander Frenzel,Hans Binder,Nadja Walter et al.
Alexander Frenzel et al.
Body shape and composition are heterogeneous among humans with possible impact for health. Anthropometric methods and data are needed to better describe the diversity of the human body in human populations, its age dependence, and associati...
Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging [0.03%]
由衰老成纤维细胞构建的类器官型人类皮肤培养模型表现出皮肤老化的特征
Regina Weinmüllner,Barbara Zbiral,Adnan Becirovic et al.
Regina Weinmüllner et al.
Skin aging is driven by intrinsic and extrinsic factors impacting on skin functionality with progressive age. One factor of this multifaceted process is cellular senescence, as it has recently been identified to contribute to a declining ti...
CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians [0.03%]
CD27-CD28+ CD8+ EMRA T 细胞的非 CMV 依赖性增多与八旬老人的生存率呈正相关关系
Carmen Martin-Ruiz,Jedrzej Hoffmann,Evgeniya Shmeleva et al.
Carmen Martin-Ruiz et al.
Cytomegalovirus (CMV) seropositivity in adults has been linked to increased cardiovascular disease burden. Phenotypically, CMV infection leads to an inflated CD8 T-lymphocyte compartment. We employed a 8-colour flow cytometric protocol to a...