A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging [0.03%]
NAD+水平下降导致骨祖细胞丧失及骨质减少
Ha-Neui Kim,Filipa Ponte,Aaron Warren et al.
Ha-Neui Kim et al.
Age-related osteoporosis is caused by a deficit in osteoblasts, the cells that secrete bone matrix. The number of osteoblast progenitors also declines with age associated with increased markers of cell senescence. The forkhead box O (FoxO) ...
Christopher T Turner,Juliana Bolsoni,Matthew R Zeglinski et al.
Christopher T Turner et al.
Pressure injuries (PIs), also known as bedsores or pressure ulcers, are a major cause of death and morbidity in the elderly. The serine protease, Granzyme B (GzmB), contributes to skin aging and impaired wound healing. Aging is a major risk...
Ji Huang,Xiujie Liang,Diogo Ladeiras et al.
Ji Huang et al.
The aging kidney undergoes complex changes and is vulnerable to injury and development of chronic kidney disease (CKD) with preponderance affecting more women than men. Evidence has been presented that the type-II L-arginine:ureohydrolase, ...
The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a [0.03%]
GSK3β-β-catenin-TCF1信号通路通过上调miR-181a改善老年人初始T细胞活化功能
Zhongde Ye,Timothy M Gould,Huimin Zhang et al.
Zhongde Ye et al.
MicroRNAs play an important role in the regulation of T cell development, activation, and differentiation. One of the most abundant microRNAs in lymphocytes is miR-181a, which controls T cell receptor (TCR) activation thresholds in thymic s...
Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population [0.03%]
免疫球蛋白G糖类与汉族人痴呆之间的关联研究
Xiaoyu Zhang,Hui Yuan,Jihui Lyu et al.
Xiaoyu Zhang et al.
Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, s...
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan [0.03%]
与低基础运动能力及寿命缩短的大鼠相比，大鼠的基础运动能力和寿命越高其线粒体健康状况越好
Miguel A Aon,Sonia Cortassa,Magdalena Juhaszova et al.
Miguel A Aon et al.
The intrinsic aerobic capacity of an organism is thought to play a role in aging and longevity. Maximal respiratory rate capacity, a metabolic performance measure, is one of the best predictors of cardiovascular- and all-cause mortality. Ra...
Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains [0.03%]
差异性转录本使用情况解析阿尔茨海默病患者大脑中的基因表达变化
Diego Marques-Coelho,Lukas da Cruz Carvalho Iohan,Ana Raquel Melo de Farias et al.
Diego Marques-Coelho et al.
Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the pathophysiological processes involved in AD onset and progression are still poorly understood. Among numerous strategies, a comprehensive overview of g...
Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss [0.03%]
在Keap1基因敲除小鼠中激活NRF2通路可减轻老年性听力损失的进展
Tetsuya Oishi,Daisuke Matsumaru,Nao Ota et al.
Tetsuya Oishi et al.
Age-related hearing loss (AHL) is a progressive sensorineural hearing loss in elderly people. Although no prevention or treatments have been established for AHL, recent studies have demonstrated that oxidative stress is closely related to p...
NQO1 protects obese mice through improvements in glucose and lipid metabolism [0.03%]
NQO1通过改善糖脂代谢来保护肥胖小鼠
Andrea Di Francesco,Youngshim Choi,Michel Bernier et al.
Andrea Di Francesco et al.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenes...
Fenofibrate prevents iron induced activation of canonical Wnt/β-catenin and oxidative stress signaling in the retina [0.03%]
非诺贝特通过抑制视网膜铁诱导的经典Wnt/β-连环蛋白和氧化应激信号通路来预防糖尿病视网膜病变
Ashok Mandala,Austin Armstrong,Becky Girresch et al.
Ashok Mandala et al.
Accumulating evidence strongly implicates iron in the pathogenesis of aging and disease. Iron levels have been found to increase with age in both the human and mouse retinas. We and others have shown that retinal diseases such as age-relate...