An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites [0.03%]
丙氨酸扩展的PABPN1引起内含子多聚腺苷酸化位点利用增加
Tooba Abbassi-Daloii,Soheil Yousefi,Eleonora de Klerk et al.
Tooba Abbassi-Daloii et al.
In eukaryote genomes, the polyadenylation site marks termination of mature RNA transcripts by a poly-adenine tail. The polyadenylation site is recognized by a dynamic protein complex, among which the poly-adenine-binding protein nuclear1 pl...
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span [0.03%]
DNA修复因子dPrp19泛表达通过减少DNA损伤延长果蝇寿命
Kathrin Garschall,Hanna Dellago,Martina Gáliková et al.
Kathrin Garschall et al.
Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to de...
Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster [0.03%]
重叠和独立的机制决定饮食及胰岛素配体敲除如何延长果蝇寿命
Jelle Zandveld,Joost van den Heuvel,Bastiaan J Zwaan et al.
Jelle Zandveld et al.
Lifespan in many organisms, including Drosophila melanogaster, can be increased by reduced insulin-IGF-like signaling (IIS) or by changes in diet. Most studies testing whether IIS is involved in diet-mediated lifespan extension employ only ...
Shin-Ichiro Imai
Shin-Ichiro Imai
Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress [0.03%]
衰老应激下听觉细胞功能和形态受损的线粒体观测
Teru Kamogashira,Ken Hayashi,Chisato Fujimoto et al.
Teru Kamogashira et al.
We aimed at determining the mitochondrial function in premature senescence model of auditory cells. Short exposure to H2O2 (1 h, 0.1 mM) induced premature cellular senescence in House Ear Institute-Organ of Corti 1 auditory cells. The trans...
Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells [0.03%]
人多能干细胞向泪腺上皮样细胞分化的转录因子诱导识别
Masatoshi Hirayama,Shigeru B H Ko,Tetsuya Kawakita et al.
Masatoshi Hirayama et al.
Dry eye disease is the most prevalent pathological condition in aging eyes. One potential therapeutic strategy is the transplantation of lacrimal glands, generated in vitro from pluripotent stem cells such as human embryonic stem cells, int...
Late-onset dementia: a mosaic of prototypical pathologies modifiable by diet and lifestyle [0.03%]
迟发性痴呆：可通过饮食和生活方式改变的典型病理变化的镶嵌图案
Mark P Mattson
Mark P Mattson
Idiopathic late-onset dementia (ILOD) describes impairments of memory, reasoning and/or social abilities in the elderly that compromise their daily functioning. Dementia occurs in several major prototypical neurodegenerative disorders that ...
Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models [0.03%]
阿尔茨海默病模型中细胞外囊泡相关Aβ介导的突触神经元 bioenergetic 和 ca2+ 处理缺陷
Erez Eitan,Emmette R Hutchison,Krisztina Marosi et al.
Erez Eitan et al.
Alzheimer's Disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs) are small 50-150 nanometer membrane vesicles that ha...
Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis [0.03%]
蛋白质稳态受损通过影响神经元的形态重塑来调节秀丽隐杆线虫的衰老过程
Elena M Vayndorf,Courtney Scerbak,Skyler Hunter et al.
Elena M Vayndorf et al.
Understanding cellular outcomes, such as neuronal remodeling, that are common to both healthy and diseased aging brains is essential to the development of successful brain aging strategies. Here, we used Caenorhabdits elegans to investigate...
Alaattin Kaya,Siming Ma,Brian Wasko et al.
Alaattin Kaya et al.
The budding yeast has served as a useful model organism in aging studies, leading to the identification of genetic determinants of longevity, many of which are conserved in higher eukaryotes. However, factors that promote longevity in labor...