Masato Iwabu,Miki Okada-Iwabu,Toshimasa Yamauchi et al.
Masato Iwabu et al.
Adipocytes are not merely organs for energy conservation but endocrine organs secreting a wide array of physiologically active substances, i.e., adipokines. Of these adipokines, adiponectin is known to exert anti-diabetic and anti-atheroscl...
Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C [0.03%]
精细定位CETP基因座发现与HDL-C相关的常见内含子插入突变
Elisabeth M van Leeuwen,Jennifer E Huffman,Joshua C Bis et al.
Elisabeth M van Leeuwen et al.
Background: Individuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in th...
Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation [0.03%]
中枢神经系统和脂肪组织BDNF/TrkB轴在代谢调节中的作用
Atsushi Nakagomi,Sho Okada,Masataka Yokoyama et al.
Atsushi Nakagomi et al.
Background/objectives: Brain-derived neurotrophic factor (BDNF) and its receptor (tropomyosin-related kinase B: TrkB, also known as Ntrk2) have a key role in central regulation of the energy balance. BDNF and TrkB are als...
The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease [0.03%]
雷帕霉素哺乳动物目标在认知衰老和阿尔茨海默病的交叉路口
Joshua S Talboom,Ramon Velazquez,Salvatore Oddo
Joshua S Talboom
Age-dependent cognitive decline is a major debilitating event affecting even individuals who are otherwise healthy. Understanding the molecular basis underlying these changes may increase the healthspan of the elderly population. It may als...
Aging science comes of age [0.03%]
衰老研究正走向成熟
Kazuo Tsubota
Kazuo Tsubota
'Purpose in Life' as a psychosocial resource in healthy aging: an examination of cortisol baseline levels and response to the Trier Social Stress Test [0.03%]
“生活目标”在健康老龄化过程中的心理社会资源作用：对皮质醇基础水平和特里尔社会压力测试反应的考察
Nia Fogelman,Turhan Canli
Nia Fogelman
'Purpose in Life' (Purpose) is associated with healthy aging, but it is unknown whether this association is causal. Conceptualizing Purpose as a form of psychosocial resource, one mechanism promoting health could be the regulation of stress...
Markers of T-cell senescence and physical frailty: insights from Singapore Longitudinal Ageing Studies [0.03%]
取自新加坡纵向老龄化研究的T细胞衰老标志物与身体衰弱的关系
Tze Pin Ng,Xavier Camous,Ma Shwe Zin Nyunt et al.
Tze Pin Ng et al.
Background: Elderly individuals have an eroded immune system but whether immune senescence is implicated with the development of frailty is unknown. The underlying immune mechanisms and the link between markers of senesce...
Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies [0.03%]
现代社会蓝光诱导的昼夜节律紊乱导致潜在健康危害的全球上升趋势
Megumi Hatori,Claude Gronfier,Russell N Van Gelder et al.
Megumi Hatori et al.
Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and sen...
Conserved and species-specific molecular denominators in mammalian skeletal muscle aging [0.03%]
哺乳动物骨骼肌衰老中的保守分子标志和物种特异性分子标志
Evi M Mercken,Miriam Capri,Bethany A Carboneau et al.
Evi M Mercken et al.
Aging is a complex phenomenon involving functional decline in multiple physiological systems. We undertook a comparative analysis of skeletal muscle from four different species, i.e. mice, rats, rhesus monkeys, and humans, at three differen...
Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells [0.03%]
致癌的MIR17HG和抑癌的MIR100HG簇及其基因靶点通过调控人类成体干细胞的复制性衰老相互拮抗
Mary F Lopez,Ping Niu,Lu Wang et al.
Mary F Lopez et al.
Growing evidence suggests that many diseases of aging, including diseases associated with robust changes and adipose deports, may be caused by resident adult stem cell exhaustion due to the process called cellular senescence. Understanding ...