An immunomodulatory decellularized pulp matrix hydrogel promotes vascularized dental pulp regeneration through angiogenic-odontogenic coupling [0.03%]
一种免疫调节的脱细胞牙髓基质水凝胶通过促血管生成/成牙本质偶联促进血管化牙髓再生
Ping Yi,Runling Zeng,Zihao Gao et al.
Ping Yi et al.
Maintaining the vitality of inflamed or exposed pulp is critical for long-term tooth preservation in clinical dentistry. Vital pulp therapy (VPT), achieved by placing bioactive materials over the exposed pulp tissue, aims to preserve pulp f...
Topological optimization synergized with a high-activity nano-hydroxyapatite coating to enhance bone regeneration in a porous titanium alloy scaffold [0.03%]
拓扑优化与高性能纳米羟基磷灰石涂层协同促进多孔钛合金支架的骨再生
Peng Zhao,Yushuan Jia,Jingming Li et al.
Peng Zhao et al.
Surface bioinertness-induced fibrosis at and within 3D-printed porous titanium implants critically impairs their repair efficacy. Surface bioactive and evenly distributed coating construction represents an ideal strategy to address this cha...
Comparative regenerative mechanisms of adipose-derived mesenchymal stem cell- and conditioned medium-loaded three-dimensional bioprinted hydrogels in chronic diabetic wounds [0.03%]
负载脂肪源性间充质干细胞和诱导介质的三维生物打印水凝胶在慢性糖尿病伤口修复中的再生机制比较研究
Lili Wang,Xiaoqi Li,Xinyu Zhang et al.
Lili Wang et al.
Chronic diabetic wounds remain a major clinical challenge owing to impaired angiogenesis, persistent inflammation and cellular dysfunction. In this study, we developed a bioadhesive composite hydrogel scaffold (gelatin methacryloyl/alginate...
PLGA/SF/linagliptin wound matrix-induced membrane promotes diabetic wounds healing by inhibiting macrophage pyroptosis [0.03%]
PLGA/SF/利那格列汀伤口敷料通过抑制巨噬细胞焦亡促进糖尿病创面愈合
Yizhuo Ren,Yanlong Wang,Kaixuan Cai et al.
Yizhuo Ren et al.
Diabetic wounds often exhibit delayed healing because of persistent inflammation, thus, remaining in the inflammatory phase. A key factor driving the delayed healing is pyroptosis, a proinflammatory form of programmed cell death which leads...
A novel collagen hydrogel loaded with primary brown sugar for accelerating burn wound healing by a synergistic mechanism [0.03%]
一种新型胶原蛋白水凝胶加载初级红糖通过协同机制加速烧伤创面修复
Ziying Guan,Liren Wei,Liaoyuan Han et al.
Ziying Guan et al.
Severe skin burns present complex clinical challenges, including delayed healing and scar formation. As the first-extracted product of sugarcane, brown sugar has a long application history in Chinese traditional medicine. Inspired by its me...
Pitaya‑inspired compartmentalized microspheres with natural tannic acid-copper coating orchestrate smart release of ions and multi-drugs for synergistic treatment of infected bone defects [0.03%]
一种基于仙人掌果的分隔型微球，其天然单宁酸-铜包衣可实现离子和多种药物的智能释放，以协同治疗感染性骨缺损
Dongbiao Chang,Zhenfan Bai,Linke Li et al.
Dongbiao Chang et al.
Infected bone defects present a significant clinical challenge, as persistent bacterial burden and exacerbated inflammatory response induce microenvironmental acidification, which severely compromises tissue regeneration. Therefore, this st...
Advances in biomimetic mineralized biomaterials for bone tissue engineering [0.03%]
仿生矿化生物材料在骨组织工程研究中的进展
Zefang Li,Wei Sun,Shuaicong Huang et al.
Zefang Li et al.
The intricate orchestration of bone biomineralization-where cells, signaling molecules and organic matrix tightly cooperate to produce native bone with remarkable strength and dynamic biological activities-exemplifies a pinnacle of evolutio...
Evaluation of bone formation within β-tricalcium phosphate scaffolds in a sheep scapular bioreactor model using micro-computed tomography analysis [0.03%]
基于微观CT分析的β-三钙磷酸盐支架在山羊肩胛骨生物反应器模型中成骨作用评估研究
D S Abdullah Al Maruf,Matt Darnell,Jiongyu Ren et al.
D S Abdullah Al Maruf et al.
Critical-sized bone defects in load-bearing regions remain a major clinical challenge. This study investigated how β-tricalcium phosphate (βTCP) scaffold pore size and stem cell source influence bone regeneration using a laser-sintered, p...
A dual-functional PEG-tyrosine hydrogel with photothermal effect and antioxidant capacity for cancer therapy and tissue regeneration [0.03%]
一种具有光热效应和抗氧化能力的双重功能PEG-酪氨酸水凝胶用于癌症治疗和组织再生
Haitao Zhu,Yunfan Shen,Zhebin Wu et al.
Haitao Zhu et al.
Achieving optimal tumor eradication while minimizing off-target toxicity and enhancing patient recovery remains a central challenge in translational oncology. Traditional therapies such as radiotherapy and chemotherapy are associated with s...
A review on thermoresponsive PNIPAM hydrogels for regenerative medicine: from mechanical design to tissue adhesion [0.03%]
PNIPAM温敏水凝胶的可调控性能在再生医学中的应用：从机械设计到组织粘附
Aaima Siddiqui,Muhammad Touqeer,Farjana Akter Ritu et al.
Aaima Siddiqui et al.
Poly(N-isopropylacrylamide) (PNIPAM) hydrogels are potential wound dressings due to their lower critical solution temperature (LCST) of 32°C, close to physiological temperature, enabling injectable or spreadable formulations that quickly f...