A CD36-targeted aptamer-4-butyl-polyhydroxybenzophenone conjugate with pH-responsive release for liver delivery in MASLD [0.03%]
一种针对CD36的酸响应型释放的适配体-4-丁基苯并酚共轭物，用于NASH肝靶向输送
Luyao Ren,Yuxi Qin,Hongxiao Lu et al.
Luyao Ren et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widespread chronic liver disease worldwide, making efficient targeted delivery systems essential to alleviate its socioeconomic burden. Aptamers are short, single-strande...
Herbal polysaccharides-a rising star in engineering multifunctional biomaterials for tissue repair and regeneration [0.03%]
多糖-用于组织修复和再生多功能生物材料构建的新兴支架分子
Rui Huang,Xiudan Zheng,Zhijun Liu et al.
Rui Huang et al.
Herbal polysaccharides (HPs) derived from traditional Chinese medicine are rapidly emerging as versatile biomaterials in the field of tissue regeneration. These natural glycans function as unique carrier-effector systems that harmonize inhe...
The next generation of alginate dressings: recent innovations for chronic wound healing [0.03%]
下一代藻酸盐敷料：慢性伤口愈合的近期创新
Eduarda Pinto,Cristina C Barrias,Judite Novais Barbosa
Eduarda Pinto
Chronic wounds remain a major clinical challenge with a huge associated socioeconomic burden. Therefore, multifunctional biomaterials that can simultaneously manage exudate, modulate inflammation, prevent infection and promote tissue regene...
Photosynthetic alginate dressing enables sustained oxygen delivery through chloroplast-powered Hill reaction to promote angiogenesis and macrophage reprogramming for chronic wound healing [0.03%]
叶绿体驱动的海藻酸盐敷料通过光合作用持续供氧促进创面新生血管形成及巨噬细胞重编程以加速慢性难愈合伤口修复的新策略研究
Yifan Zhang,Lanqin Yu,Min Fang et al.
Yifan Zhang et al.
Chronic wounds are very difficult to heal due to persistent hypoxia, impaired angiogenesis and dysregulated inflammation. To address these problems, we developed a photosynthetic hydrogel dressing (SFCc) by integrating chloroplasts into an ...
Three-dimensionally-printed biphasic PCL/ β-TCP scaffold with spatially confined GelMA/CS hydrogel for coordinated osteochondral regeneration [0.03%]
一种用于协同软骨骨再生的三维多孔分层PCL/β-TCP/GelMA/CS支架
Feng Zhou,Xiaoyun Pan,Qixiang Yin et al.
Feng Zhou et al.
Osteochondral defects remain difficult to repair because articular cartilage and subchondral bone differ in structure and regenerative capacity, and stable interface integration is challenging. Here, we developed a structurally continuous y...
Complementary antioxidant strategy for diabetic wound healing: myricetin and ceria nanozymes for enhanced reactive oxygen species management [0.03%]
用于糖尿病伤口愈合的辅助抗氧化策略：芦丁和氧化铈纳米酶协同管理活性氧
Xiaoxiao Liao,Lei Song,Shancan Wang et al.
Xiaoxiao Liao et al.
Diabetic wounds are characterized by persistent oxidative stress, hypoxia and chronic inflammation, leading to delayed healing and high risk of recurrence. Conventional antioxidants such as polyphenols can rapidly scavenge reactive oxygen s...
Holmium vanadate nanoparticles as a biosafe and efficient contrast agent for spectral CT imaging of gastritis and colitis [0.03%]
纳米 holmium vanadate 颗粒作为内窥镜检查的生物安全高效对比剂用于肠炎和结肠炎的光谱CT成像研究
Wenqian Ru,Chunmei Yang,Xin Zhu et al.
Wenqian Ru et al.
The development of a biosafe and high-performance spectral computed tomography (CT) contrast agent for the specific and non-invasive diagnosis of gastrointestinal diseases represents a significant clinical need. Unlike conventional CT, whic...
CaAm-P19: a novel amelogenin-derived peptide for enamel remineralization [0.03%]
新型牙本质磷蛋白肽CaAm-P19促进牙齿再矿化作用的研究
Xiaoqian Ding,Xin Li,Cynthia Kar Yung Yiu et al.
Xiaoqian Ding et al.
Dental caries remains a prevalent global oral disease characterized by the progressive demineralization of dental hard tissues. Effective remineralization strategies are necessary to arrest its progression and repair the resulting structura...
Bioinspired enzymatic polyphenolic nanoplatform for redox modulation and functional renal restoration in diabetic nephropathy [0.03%]
糖尿病肾病中用于氧化还原调节和功能肾脏恢复的仿生酶聚酚纳米平台
Linli Cai,Tianyou Wang,Yin Huang et al.
Linli Cai et al.
Oxidative stress is a central pathological driver in diabetic nephropathy (DN), leading to excessive reactive oxygen species (ROS) generation, chronic inflammation and progressive renal fibrosis. Effective modulation of oxidative imbalance ...
Vitronectin-GM-CSF fusion protein hydrogel with a recruitment-anchoring-activation strategy accelerates vascularized tissue regeneration [0.03%]
利用招募-锚定-激活策略的粘连蛋白-粒细胞-巨噬细胞刺激因子融合蛋白水凝胶促进血管化组织再生
Jiake Zhang,Yuhan Xia,Xueliang Peng et al.
Jiake Zhang et al.
The process of tissue injury repair involves the synergistic effects of angiogenesis and immune regulation, yet a single molecule rarely can regulate both processes. To address this, we designed a fusion protein, VGC, by integrating the pot...