Development and optimization of electrophoretically deposited octacalcium phosphate-collagen film as bone analogues [0.03%]
作为骨类体的电泳沉积八钙磷酸-胶原膜的开发与优化
Katrina J Staunton-Mann,Gengyao Wei,Thomas Kress et al.
Katrina J Staunton-Mann et al.
The hierarchical architecture of bone, characterized at the nanoscale, is defined by mineralized collagen fibrils with a disordered, hydrated, carboxylate-rich mineral surface, presenting a complexity often absent in conventional hydroxyapa...
Mengshi Chen,Siyi Chen,Yapei Song et al.
Mengshi Chen et al.
Decellularized tissues have attracted considerable attention in tissue engineering and regenerative medicine due to their diverse sources and excellent biocompatibility. However, current decellularization techniques often compromise the int...
Triamcinolone acetonide-loaded chitosan-polyethylene glycol hydrogel for preventing esophageal stricture post-endoscopic submucosal dissection [0.03%]
载有倍他米松的壳聚糖-聚乙二醇水凝胶在内镜下黏膜剥离术后的应用以预防食管狭窄发生率
Yaqiang Li,Rui Gao,Zhen He et al.
Yaqiang Li et al.
Postoperative esophageal stricture remains a significant challenge following endoscopic submucosal dissection (ESD), with limited effective prophylactic options in clinic. Here, we report the development of an injectable and tissue-adhesive...
In vivo safety prediction of recombinant collagen using in vitro simulated degradation analysis, chronic toxicity and immunological evaluation [0.03%]
基于体外模拟降解分析、慢性毒理及免疫学评价的重组胶原蛋白体内安全性预测
Can Huang,Jie Li,Xueyimu Aou et al.
Can Huang et al.
Protein-based biomaterials, particularly collagen-derived materials, have been widely applied in medical devices and regenerative medicine due to their excellent biocompatibility and tissue repair-promoting functions. However, the degradati...
Cationic microparticles inhibit local sterile inflammation in tissue injuries [0.03%]
阳离子微粒抑制组织损伤中的局部无菌炎症反应
Ying Zhang,Hanyao Huang,Jaewoo Lee et al.
Ying Zhang et al.
Sterile inflammation driven by circulating cell-free nucleic acids (cfNAs) plays a critical role in immune activation across various pathological conditions, including autoimmune diseases and tissue injuries. In this study, we explore the p...
ROS-responsive adhesive nanocomposite hydrogel promotes tendon-to-bone healing by modulating the inflammatory microenvironment and pro-differentiation [0.03%]
响应性粘合纳米复合水凝胶通过调节炎性微环境和促进腱骨愈合来促进细胞分化
Shaowei Zheng,Jiang Guo,Lin Li et al.
Shaowei Zheng et al.
Natural functional regeneration of the tendon-bone interface in rotator cuff repair surgery remains a major challenge and requires the development of innovative therapeutic strategies. Hydrogels with biomechanical adaptability and regenerat...
A microgel-stabilized, light-controlled artificial energy supply module for efficient biosynthesis [0.03%]
一种微凝胶稳定、光控人工能源供应模块用于高效生物合成
Shaoyang Kang,Sheng Ding,Donghao Lyu et al.
Shaoyang Kang et al.
Artificial energy supply modules that can produce adenosine triphosphate (ATP) through natural or synthetic structures are crucial for supporting artificial cells with therapeutic purposes. However, their advanced biomedical application is ...
Plasma-derived mitochondria as a minimal manipulation alternative for attenuating inflammatory immune responses [0.03%]
一种通过最少干预手段利用血浆源性线粒体来抑制炎症免疫反应的方法
Seong-Hoon Kim,Eun-Seo Back,Ikhyun Lim et al.
Seong-Hoon Kim et al.
Platelet-rich plasma (PRP) has long been used to promote tissue repair through its content of cytokines, growth factors and platelet-derived mitochondria (PLT-mito). While effective, PRP often triggers an early M1-type inflammatory response...
Stiff matrix drives microglial cell migration through Piezo1/Ca2+/AKT/cofilin signaling axis-regulated F-actin reassembly [0.03%]
刚性基底模体通过Piezo1/Ca2+/AKT/cofilin信号轴调节F肌动蛋白重组促进小胶质细胞迁移
Xinlan Chen,Zhongchen Li,Junqi Men et al.
Xinlan Chen et al.
The local stiffness of brain tissues increases in pathological states, and then, drives microglial cells to migrate towards stiffer areas for their functioning, but the underlying mechanism is still unclear. Herein, we investigated the role...
Magnesium-doped bioactive glass enhances bone regeneration by reversing replicative senescence of human dental pulp stem cells in bone defect therapy [0.03%]
镁掺杂生物活性玻璃通过逆转人牙髓干细胞复制性衰老促进骨缺损治疗中的骨再生
Xin Yan,Xiangdong Li,Qi Zhang et al.
Xin Yan et al.
Human dental pulp stem cells (hDPSCs) exhibit replicative senescence during in vitro expansion, leading to a reduction in osteogenic differentiation capacity and thereby limiting their potential for bone defect regeneration. Magnesium ion (...