Acellular nerve perineurium repairs peripheral nerve injuries in a rat model via ECM-mediated barrier and optimization of the regenerative microenvironment [0.03%]
脱细胞神经周膜通过基质介导的屏障和优化修复微环境修复大鼠周围神经损伤
Fulin He,Zhenpeng Li,Fawei Liao et al.
Fulin He et al.
Building upon the clinically established platform of acellular nerve allografts (ANAs), we developed an advanced derivative: acellular nerve perineurium (ANP) grafts. These grafts are characterized by their preservation of the native perine...
Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering [0.03%]
用于防治感染和组织工程的骨科植入物生物材料的协同整合研究进展
Longhui Xu,Xu Chen,Zeyang Cao et al.
Longhui Xu et al.
The treatment of infected bone defects (IBD) is challenging in orthopedics because of their complex pathological mechanisms and high recurrence rates. An ideal therapeutic strategy should simultaneously eradicate infection and promote bone ...
Mitochondria-targeted nanotechnology in cardiovascular diseases: a review of recent advances [0.03%]
心血管疾病中靶向线粒体的纳米技术最新进展评述
Sijia Sun,Manxiang Wu,Pengli Zhang et al.
Sijia Sun et al.
Cardiovascular diseases (CVDs) remain the leading cause of global mortality, with mitochondrial dysfunction serving as a central pathological hub in conditions such as atherosclerosis, myocardial ischemia-reperfusion injury and heart failur...
Biomaterial regulation of excessive inflammation restores osteoimmune homeostasis in diabetic bone regeneration [0.03%]
生物材料调控过度炎症恢复糖尿病骨再生中的软骨-免疫稳态
Qiyue Zhou,Yu Zhang,Zhuo Dai et al.
Qiyue Zhou et al.
Diabetes mellitus markedly increases the incidence of fractures, implant failure and nonunion, primarily because chronic low-grade inflammation and a disrupted bone microenvironment impair regeneration. Under physiological conditions, coord...
Advanced materials and devices strategies of mechanical stimulation for tissue regeneration [0.03%]
用于组织再生的机械刺激的先进材料和器件策略
Mengting Huan,Huihui An,Xing Sheng et al.
Mengting Huan et al.
Mechanical stimulation as a form of physical therapy plays a crucial role in regulating cellular behavior and promoting tissue regeneration. It can influence cell proliferation, differentiation, migration and extracellular matrix deposition...
An interfacial hydrogel compartment within a multicompartment tendon-to-bone scaffold influences cell behavior under cyclic tensile loading [0.03%]
界面水凝胶隔室对多隔室肌腱-骨支架中细胞行为的影响研究
Kyle B Timmer,Megan L Killian,Brendan A C Harley
Kyle B Timmer
Injuries to spatially graded insertional tissues such as the tendon-to-bone enthesis in the rotator cuff present unique challenges for regenerative engineering. To address these, tissue engineering approaches are increasingly considering th...
A novel dual-targeting strategy to suppress cariogenic bacteria and biofilms with engineered ARG/FBG bioactive composites [0.03%]
一种针对致龋菌和菌斑的新颖双重靶向策略及工程化ARG/FBG生物活性复合物
Xili Qiu,Tongjun Li,Jincai Guo et al.
Xili Qiu et al.
Dental caries is a biofilm-mediated disease primarily driven by Streptococcus mutans (S. mutans), which ferments dietary sugars to produce acids that demineralize enamel. This study developed a novel composite combining L-arginine (ARG) and...
Stimuli-responsive hydrogels for radiation-induced skin injury: from passive barriers to autonomous drug delivery systems [0.03%]
用于放射性皮肤损伤的刺激响应型水凝胶：从被动屏障到自主药物输送系统
Kai Zhang,Chulan Xiao,Yuanyuan Wang et al.
Kai Zhang et al.
Radiation-induced skin injury (RISI) affects over 95% of radiotherapy patients. Current clinical management remains confined to passive supportive care, lacking mechanistic precision for RISI's unique pathophysiology. This review adopts a f...
Betaine based organ preservation solution alleviates renal allograft I/R injury by protecting endothelial cells [0.03%]
betaine基器官保存液通过保护内皮细胞减轻同种异体肾移植缺血/再灌注损伤
Mingxing Yu,Shuo Li,Xu Duan et al.
Mingxing Yu et al.
Static cold preservation remains a cornerstone of transplantation, and high-performance organ preservation solutions, sharing the same goal as regenerative biomaterials, are indispensable for facilitating the regeneration and functional rec...
Khan Haroon,Jie Yu,Renke Li et al.
Khan Haroon et al.
Extracellular vesicles (EVs) are versatile, cell-derived complexes that serve as a complete package of biologically important molecules, released during both normal and pathological processes. With rapid advancements in EVs research, there ...