Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections [0.03%]
微流体辅助的多重生物标志物检测技术在肿瘤切片中用于原位绘制免疫细胞地图
Daniel Migliozzi,Benjamin Pelz,Diego G Dupouy et al.
Daniel Migliozzi et al.
Because of the close interaction between tumors and the immune system, immunotherapies are nowadays considered as the most promising treatment against cancer. In order to define the diagnosis and the subsequent therapy, crucial information ...
Lucas Armbrecht,Rafael Sebastian Müller,Jonas Nikoloff et al.
Lucas Armbrecht et al.
Single-cell profiling provides insights into cellular behaviour that macroscale cell cultures and bulk measurements cannot reveal. In the context of personalized cancer treatment, the profiling of individual tumour cells may lead to higher ...
Uniaxially crumpled graphene as a platform for guided myotube formation [0.03%]
单轴起皱石墨烯促进骨骼肌管定向生长的研究
Junghoon Kim,Juyoung Leem,Hong Nam Kim et al.
Junghoon Kim et al.
Graphene, owing to its inherent chemical inertness, biocompatibility, and mechanical flexibility, has great potential in guiding cell behaviors such as adhesion and differentiation. However, due to the two-dimensional (2D) nature of graphen...
Zhensong Xu,Wenkun Dou,Chen Wang et al.
Zhensong Xu et al.
In transfusion medicine, there has been a decades-long debate about whether the age of stored red blood cells (RBCs) is a factor in transfusion efficacy. Existing clinical studies investigating whether older RBCs cause worse clinical outcom...
Predicting strength distributions of MEMS structures using flaw size and spatial density [0.03%]
基于缺陷尺寸和空间密度的MEMS结构强度分布预测方法研究
Robert F Cook,Frank W DelRio,Brad L Boyce
Robert F Cook
The populations of flaws in individual layers of microelectromechanical systems (MEMS) structures are determined and verified using a combination of specialized specimen geometry, recent probabilistic analysis, and topographic mapping. Stre...
Long Quang Nguyen,Peter Emil Larsen,Tom Larsen et al.
Long Quang Nguyen et al.
Thermal analysis is essential for the characterization of polymers and drugs. However, the currently established methods require a large amount of sample. Here, we present pyrolytic carbon resonators as promising tools for micromechanical t...
Smart-phone, paper-based fluorescent sensor for ultra-low inorganic phosphate detection in environmental samples [0.03%]
一种基于智能手机的纸基荧光传感器用于环境样品中极低浓度无机磷酸盐的检测
Mehenur Sarwar,Jared Leichner,Ghinwa M Naja et al.
Mehenur Sarwar et al.
A major goal of environmental agencies today is to conduct point-of-collection monitoring of excess inorganic phosphate (Pi) in environmental water samples for tracking aquatic "dead zones" caused by algae blooms. However, there are no exis...
Hybrid superhydrophilic-superhydrophobic micro/nanostructures fabricated by femtosecond laser-induced forward transfer for sub-femtomolar Raman detection [0.03%]
飞秒激光成型的超亲水/超疏水微纳结构及其用于zepto摩尔浓度拉曼检测研究
Xiaodan Ma,Lan Jiang,Xiaowei Li et al.
Xiaodan Ma et al.
Raman spectroscopy plays a crucial role in biochemical analysis. Recently, superhydrophobic surface-enhanced Raman scattering (SERS) substrates have enhanced detection limits by concentrating target molecules into small areas. However, due ...
Optically read Coriolis vibratory gyroscope based on a silicon tuning fork [0.03%]
一种基于硅音叉的可光学读出的科里奥利振动陀螺仪
N V Lavrik,P G Datskos
N V Lavrik
In this work, we describe the design, fabrication, and characterization of purely mechanical miniature resonating structures that exhibit gyroscopic performance comparable to that of more complex microelectromechanical systems. Compared to ...
Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing [0.03%]
一种使用低成本3d打印技术制造高宽比微针模具的简便定制方法
Kevin J Krieger,Nicky Bertollo,Manita Dangol et al.
Kevin J Krieger et al.
We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D printer. As opposed to conventional microneedle fabrication methods, this technique neither requires complex and expensive manufactu...