Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents [0.03%]
直接抗病毒治疗后慢性丙型肝炎患者的某些氧化应激标志物的可逆性
Pin-Nan Cheng,Hung-Yu Sun,I-Che Feng et al.
Pin-Nan Cheng et al.
Introduction: Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting ant...
Influencing factors and adverse outcomes of virologic rebound states in anti-retroviral-treated individuals with HIV infection [0.03%]
HIV感染者接受抗逆转录病毒治疗后病毒学反跳的影响因素及不良预后事件
Defu Yuan,Mingma Li,Ying Zhou et al.
Defu Yuan et al.
Antiretroviral therapy (ART) aims to inhibit HIV replication, decrease CD4 T cell loss, and immune function recovery in order to reduce the morbidity and mortality associated with the infection. Treatment should also, improve quality of lif...
The poliovirus re-emergence: did concentrated efforts against COVID-19 open the door? [0.03%]
新冠疫情集中防疫期间脊髓灰质炎病毒死灰复燃的原因分析
Nour Shaheen,Abdelrahman Mohamed,Abdelraouf Ramadan et al.
Nour Shaheen et al.
Combining treatment for chronic hepatitis C with opioid agonist therapy is an effective microelimination strategy for people who inject drugs with high risk of non-adherence to direct-acting antiviral therapy [0.03%]
将慢性丙型肝炎治疗与阿片受体激动剂治疗结合是针对直接抗病毒药物依从性高风险的注射吸毒者的一种有效的微消除策略
M Schwarz,C Schwarz,A Schütz et al.
M Schwarz et al.
Background & aims: Despite effective direct-acting antivirals (DAAs), hepatitis C virus (HCV) prevalence is high among people who inject drugs (PWIDs) and non-adherence to therapy remains a major obstacle towards HCV elim...
Adeno-associated virus-vectored delivery of HIV biologics: the promise of a "single-shot" functional cure for HIV infection [0.03%]
腺相关病毒载体递送HIV免疫治疗生物制剂：“单次注射”功能性治愈艾滋病的希望
Patricia A Hahn,Mauricio A Martins
Patricia A Hahn
The ability of immunoglobulin-based HIV biologics (Ig-HIV), including broadly neutralizing antibodies, to suppress viral replication in pre-clinical and clinical studies illustrates how these molecules can serve as alternatives or adjuncts ...
Highlights from the Tenth International Workshop on HIV Persistence during Therapy, December 13-16, 2022, Miami, Florida-USA [0.03%]
第二届HIV治疗存续国际研讨会会议述评
N Archin,K J Bar,T Burdo et al.
N Archin et al.
The International Workshop on HIV Persistence during Therapy provides a forum in which HIV/AIDS researchers gather to share the latest research findings related to viral reservoirs and cure. The Tenth Workshop, which was attended by over 40...
Barriers that prevent adults living with HBV infection from participating in clinical research: experience from South Africa [0.03%]
乙肝病毒感染成人参与临床研究障碍：南非的经验
Nombuyiselo Mofokeng,Tongai G Maponga,Marije van Schalkwyk et al.
Nombuyiselo Mofokeng et al.
High profile international goals have been set for the elimination of hepatitis B virus (HBV) infection as a public health threat by the year 2030. Developing and expanding equitable, accessible translational HBV research programmes that re...
Impact of hepatitis B vaccination programs in Vietnam evaluated by estimating HBsAg prevalence [0.03%]
通过估计HBsAg流行率评估越南乙肝疫苗接种计划的影响
Kenichi Komada,Yasunori Ichimura,Mami Shimada et al.
Kenichi Komada et al.
Background: Vietnam introduced a 3-dose hepatitis B (HBV) immunization program comprising 1 dose immediately after birth and 2 or 3 in infancy in the past 20 years, but the impact of the vaccine has not been systematicall...
Substantial uneven proliferation of CD4+ T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir [0.03%]
急性HIV感染恢复期间CD4+T细胞的大量不均匀增殖足以解释HIV储库中观察到的扩增克隆的数量。
Florencia A Tettamanti Boshier,Daniel B Reeves,Elizabeth R Duke et al.
Florencia A Tettamanti Boshier et al.
The HIV reservoir is a population of 1-10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA. When antiretroviral therapy (ART) is stopped and HIV repl...