Population immunity to the three serotypes of poliovirus post-interruption of wild poliovirus transmission in Nigeria [0.03%]
尼日利亚阻断野病毒传播后预防三种脊灰病毒感染的群体免疫性研究
Marycelin Mandu Baba,Aisha Abba Kawu,Sadiya Alhaji Bukar et al.
Marycelin Mandu Baba et al.
The presence of neutralizing antibodies is considered a surrogate marker of protection against the three serotypes of poliovirus. The need to use the Microneutralization test in assessing the neutralizing antibodies to the three serotypes o...
The impact of acute stress on the HIV reservoir: a prospective interventional trial [0.03%]
急性应激对HIV储存库的影响：一项前瞻性干预试验
Jared Stern,Michael Roche,Rory Shepherd et al.
Jared Stern et al.
The persistence of latently infected CD4+ T cells is the major barrier to cure of people with HIV (PWH) on antiretroviral therapy (ART). While most latently infected cells are transcriptionally silent, some express low levels of cell associ...
A liberalized approach to directly observed therapy for HCV retains excellent cure rates among PWID in Vienna [0.03%]
维也纳：对HIV阳性注射吸毒者liberal化直接观察治疗能保持极佳的治愈率
Caroline Schwarz,Angelika Schütz,Maximilian Anibas et al.
Caroline Schwarz et al.
Introduction: Directly observed therapy (DOT) is an effective strategy to optimize hepatitis C virus (HCV) cure rates in people who inject drugs (PWID) on stable opioid agonist therapy (OAT). While adherence to daily DOT ...
Serum osteopontin levels predict short-term outcomes in patients with hepatitis B-related acute-on-chronic liver failure [0.03%]
血清骨护素水平可预测乙肝相关急性-on-慢性肝衰竭患者的短期预后
Yu Liu,Miao Fang,Hongying Guo et al.
Yu Liu et al.
Background: Multiple analyses have suggested that osteopontin (OPN) is involved in acute and chronic liver disease. We aimed to investigate the value of serum OPN in predicting the short-term prognosis of patients with he...
Persistent cell-associated HIV-1 RNA in virally suppressed individuals on INSTI-based ART [0.03%]
基于INSTI的抗病毒治疗方案中获得抑制的HIV-1感染者体内持续存在的与细胞结合的HIV-1 RNA
Kazuo Suzuki,Lucy Gold,Angelique Levert et al.
Kazuo Suzuki et al.
Integrase strand transfer inhibitors (INSTIs) are the cornerstone of modern antiretroviral therapy (ART), achieving durable plasma HIV-1 suppression in most people living with HIV (PLWH). Previous comparisons of INSTI- and non-INSTI-based r...
Evolution of split-protein technologies in virology: From mechanistic discovery and diagnostics to therapeutic promise [0.03%]
病毒学中分蛋白技术的演变：从机制发现和诊断到治疗前景
Kai Zhou,Yingshou Lei,Yaoqi Zhou et al.
Kai Zhou et al.
The persistent challenge posed by viruses such as HIV, HBV, and SARS-CoV-2 necessitates the continuous evolution of molecular tools for their study and for advancing therapeutic research. Split-protein complementation assays (PCAs), where a...
2-Deoxyglucose as a therapeutic strategy for EBV-associated gastric carcinoma: Glycolytic and lytic reactivation inhibition under hypoxic conditions [0.03%]
二脱氧葡萄糖作为治疗EB病毒相关胃癌的策略：低氧条件下抑制糖酵解和再激活溶解释放效应
Yu Du,Wangsheng Zuo,Yiting Shao et al.
Yu Du et al.
Epstein-Barr virus-associated gastric carcinoma (EBVaGC), a distinct subtype of gastric cancer, accounts for approximately 10 % of all gastric cancer cases. 2-deoxyglucose (2-DG), a glycolysis inhibitor, has emerged as a crucial tool in can...
Prevalence of acquired resistance to HIV integrase strand transfer inhibitors (INSTIs) in clinical samples from treatment-experienced patients in Chile, 2012-2023 [0.03%]
2012-2023年智利接受过治疗的患者临床样本中获得性人类免疫缺陷病毒整合酶链转移抑制剂耐药性的流行率
P Ferrer,V Ramos,M Durán et al.
P Ferrer et al.
Background: Integrase strand transfer inhibitors (INSTIs) are widely used in HIV treatment, yet few large-scale studies have examined acquired resistance (AR) at the population level. This study assessed the prevalence, p...
The interprofessional nurse-physician model in comprehensive management of chronic hepatitis B: An updated review [0.03%]
慢乙肝全病程管理中的医护合作模式：更新版综述
Xiao-Ling Xiang,Fa-Da Wang,Xi-Jia Luo et al.
Xiao-Ling Xiang et al.
Chronic hepatitis B (CHB) remains a significant global public health challenge, particularly in China, where it affects over 70 million individuals. The outpatient management of CHB patients is complex due to the chronic nature of the disea...
Inhibition of protein kinase R suppresses HIV replication and integration in CD4 T cells [0.03%]
蛋白激酶R抑制可抑制CD4+T细胞中的HIV复制和整合
Jaeden Pyburn,Juan Zhao,Ling Wang et al.
Jaeden Pyburn et al.
Evaluation of CD4 T cell status in early HIV infection is critical for developing strategies targeting HIV replication. In this study, we infected CD4 T cells with HIV-1 and investigated the cell survival mechanisms in HIV-infected versus u...