Premature stopping of LEIA-HF: protecting trial participants while preserving clinical knowledge [0.03%]
LEIA-HF试验的提前终止：在保护受试者的同时保留临床知识
Johannes Grand,Anne Sophie Overgaard Olesen,Janus C Jakobsen
Johannes Grand
Sodium Portable Tester for Instantaneous Natriuresis Assessment: The SPOT-Na Study [0.03%]
便携式钠测定仪用于即时钠尿评估：SPOT-Na研究
Thomas Goria,Anaïs Curtiaud,Sabrina Garnier Kepka et al.
Thomas Goria et al.
Machine Learning Based Prediction of Hospital Mortality in Post-Cardiotomy Cardiogenic Shock with Mechanical Support [0.03%]
基于机器学习的机械辅助下心脏手术后心源性休克患者死亡率预测
Ahmad Mahajna,Michal Kawczynski,Silvia Mariani et al.
Ahmad Mahajna et al.
Aims: To develop and evaluate machine learning-based models for predicting in-hospital mortality in post-cardiotomy cardiogenic shock patients supported with extracorporeal life support, aiming to improve prognostication ...
Event rates in major Phase 3 heart failure trials over the last 20 years [0.03%]
过去20年主要3期心力衰竭试验的事件率
Alberto Aimo,Giorgia Panichella,Andrea Ripoli et al.
Alberto Aimo et al.
Aims: To determine whether control-arm event rates in heart failure (HF) randomized clinical trials (RCTs) published in NEJM from 2004-2024 declined over time, despite intensification of background therapy. ...
High-Urgency Heart Transplantation and Outcome Trade-offs: Early Post-Transplant Infection and Mortality [0.03%]
高紧迫性心脏移植及预后影响：早期移植感染与死亡率关系分析
Kyu-Sun Lee,Darae Kim,Jin-Oh Choi et al.
Kyu-Sun Lee et al.
Aims: To evaluate differences in post-transplant outcomes by pre-transplant urgency status, focusing on early post-transplant infection and its contribution to mortality. ...
Cardiac Magnetic Resonance Imaging Parameters Predict New-Onset Symptoms of Heart Failure in Hypertrophic Cardiomyopathy [0.03%]
肥厚型心肌病患者心脏磁共振参数与新发心力衰竭症状的关系研究
Danuzia S da Silva,Vanessa Karlinski Vizentin,Iuri Ferreira Felix et al.
Danuzia S da Silva et al.
Background: Hypertrophic cardiomyopathy (HCM) is a heritable cardiac disorder characterized by increased left ventricular (LV) wall thickness, often leading to heart failure (HF). HF represents a significant burden and is...
Predicted versus observed outcomes in the ALT-FLOW early feasibility study [0.03%]
ALT-FLOW早期可行性研究的预期结果与实际观察结果的对比分析
Francesco Fioretti,William A Gray,Benjamin Hibbert et al.
Francesco Fioretti et al.
Background and aims: Whether hemodynamic and symptomatic benefits of the APTURE left atrial-to-coronary sinus shunt translate into clinical outcome benefit in heart failure with left ventricular ejection fraction >40% rem...
Hypercontractile Phenotype at Rest in Chronic Coronary Syndromes Predicts Impaired Functional Reserve and Increased Mortality [0.03%]
慢性冠状动脉综合征中静息高收缩表型与功能储备障碍和死亡率增加有关
Quirino Ciampi,Yi Wang,Lauro Cortigiani et al.
Quirino Ciampi et al.
Background: Transthoracic echocardiography (TTE) identifies a hypercontractile phenotype (HP) in chronic coronary syndromes (CCS), characterized by elevated resting left ventricular (LV) elastance (Force = systolic blood ...
Global Trend and Predictors of Non-Labeled Sacubitril-Valsartan Dosing: Results from IKNOW-HF Survey [0.03%]
未标注的沙库必利-缬沙坦剂量的全球趋势和预测因素：IKNOW-HF调查结果
Israa Fadhil Yaseen,Hasan Ali Farhan,Justin Paul Gnanaraj et al.
Israa Fadhil Yaseen et al.
Background: Optimizing guideline-directed medical therapy (GDMT) remains vital for heart failure (HF) management. However, non-labeled dosing of sacubitril-valsartan is increasingly reported. ...
Efficacy of ARNIs on Hard Renal Outcomes in Heart Failure with and without Chronic Kidney Disease: When Endpoint Definition Matters-An Updated Meta-Analysis [0.03%]
ARNI对心力衰竭伴或不伴慢性肾脏病患者肾脏硬终点的影响：定义结局指标的重要性-一项荟萃分析的更新结果
Giuseppe Cianciolo,Daniele Vetrano,Alessandro Tomassetti et al.
Giuseppe Cianciolo et al.
Background: The renal effects of sacubitril/valsartan (Sac/Val) in heart failure (HF) remain incompletely defined, partly because kidney outcomes in pivotal HF trials have been variably prespecified and heterogeneously de...