Satralizumab treatment in adults with aquaporin-4 immunoglobulin G-seropositive neuromyelitis optica spectrum disorder in clinical practice [0.03%]
临床实践中成人AQP4-IgG阳性神经免疫性疾病患者的satralizumab治疗
Hesham Abboud,Brian Steingo,Diana Vargas et al.
Hesham Abboud et al.
Background: Satralizumab is approved for aquaporin-4 immunoglobulin G-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD), but real-world data are limited. This case series aimed to describe real-world exp...
Barriers to care for people with unclear visual loss-Data from a tertiary-level-of-care neuroinflammation center [0.03%]
不明视觉障碍患者治疗障碍的防治——来自一家三级神经炎症诊疗中心的数据
Murat Delikaya,Charlotte Bereuter,Jan Schroeter et al.
Murat Delikaya et al.
Background: Visual symptoms are common in people with multiple sclerosis. The revised 2024 McDonald criteria include the optic nerve as a fifth anatomical region, underscoring the need for specific diagnostics. Although o...
Semantic networks in relapsing-remitting multiple sclerosis exhibit reduced efficiency, interconnectivity, and flexibility [0.03%]
复发缓解性多发性硬化的语义网络表现出效率降低、互联性和灵活性下降
Sophia Lall,Jennifer Pardo,Joshua Sandry
Sophia Lall
Background: Word-finding deficits are common in persons with relapsing-remitting multiple sclerosis (pwRRMS); this may be related to the inefficient organization of semantic information. ...
Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis [0.03%]
视神经脱髓鞘导致的视盘胶质细胞丢失与多模态视觉功能障碍有关
Mustafa Subhi,Sargis Manukyan,Gabriela Zabala et al.
Mustafa Subhi et al.
Background: Optic neuritis (ON) is a common manifestation of multiple sclerosis and related disorders (MSRD) characterized by retinal neurodegeneration, including thinning of ganglion cell-inner plexiform layer (GCIPL). C...
Hypogammaglobulinemia and infection rates in patients with multiple sclerosis treated with ocrelizumab for up to six years: A real-world single-center study [0.03%]
为期长达六年奥法木单抗治疗的多发性硬化患者的低丙种球蛋白血症和感染率：一项单一中心真实世界研究
B Khatri,P Van Zealand,S Tarima et al.
B Khatri et al.
Objectives and aims: Ocrelizumab (OCR) is disease-modifying therapy that depletes B cells for the treatment of patients with relapsing and progressive multiple sclerosis (MS). The aim of this study was to evaluate occurre...
Safety reporting quality in multiple sclerosis clinical trials: A review of phase III clinical trials included in FDA approval of disease-modifying treatments [0.03%]
多项硬化症临床试验的安全报告质量：包含于FDA的疾病修正治疗审批程序中的三期临床试验回顾
William Z Lin,Jaimie J Lee,Anibal Chertcoff et al.
William Z Lin et al.
Background: Evaluating safety of emerging interventions is important in clinical trials. To support reporting of safety outcomes, a harms extension of the Consolidated Standards of Reporting Trial (CONSORT) guidelines was...
The impact of early life stress on patient-reported outcomes in multiple sclerosis [0.03%]
早期生活压力对多发性硬化症患者报告结果的影响
Myla Goldman,Shanshan Chen,Rylan Pearsall et al.
Myla Goldman et al.
Background: Early life stress (ELS) has been implicated in the risk of developing autoimmune disorders including multiple sclerosis (MS), but less is known about its relationship to the clinical course of MS. ...
Transition from anti-CD20 therapies to fumarates as a treatment strategy: A multicenter, retrospective observational experience [0.03%]
从抗CD20疗法转换为富马酸类药物治疗的经验：一项多中心回顾性观察研究
Brandi L Vollmer,Tammy Hoyt,Timothy W West et al.
Brandi L Vollmer et al.
We present real-world data on patients switching from anti-CD20s to fumarates for various motivations in this retrospective observational study of 43 patients from three multiple sclerosis centers. Recurrent infections on anti-CD20s were th...
Validity and reliability of fatigue scale for motor and cognitive functions (FSMC) in an Iranian population of people with multiple sclerosis [0.03%]
伊朗多发性硬化症患者身心疲劳量表（FSMC）的有效性和可靠性研究
Farinaz Tabibian,Armin Adibi,Ali Motahharynia et al.
Farinaz Tabibian et al.
Introduction: Multiple sclerosis (MS) is a central nervous system disorder and is frequently associated with fatigue. The Fatigue Scale for Motor and Cognitive Functions (FSMC) is an instrument to assess both motor and co...
The presence of a paramagnetic phase rim in multiple sclerosis is linked to lesion age: An exploratory study [0.03%]
多发性硬化症中存在.paramagnetic相带与病变年龄有关：一项探索性研究
Samuel Klistorner,Tatiana Usnich,Margareta A Clarke et al.
Samuel Klistorner et al.
Background: In relapsing-remitting multiple sclerosis (RRMS), smouldering inflammation at the rims of chronic active lesions is increasingly recognised as a key driver of disease progression. Paramagnetic rim lesions (PRL...