Sex-dependent bioactive lipid mediator profiles in multiple sclerosis [0.03%]
多发性硬化症的性别依赖型生物活性脂质介质谱型
Wing Hee Fung,Serhii Chornyi,Menno M Schoonheim et al.
Wing Hee Fung et al.
Background: Pathophysiological drivers of sex differences in multiple sclerosis (MS) remain unclear. Potential candidates include bioactive lipid mediators (LMs), which are pivotal regulators of neuro-inflammatory respons...
Real-world adherence to and persistence with ofatumumab, infusion, oral, and other self-injectable disease-modifying therapies in patients with multiple sclerosis [0.03%]
奥法木单抗、输液、口服和其它自体注射型疾病修正疗法在多发性硬化患者中的真实世界依从性和持久性研究
Ming-Hui Tai,Brandon Brown,Riley Taiji et al.
Ming-Hui Tai et al.
Background: Treatment schedule complexity and route of administration may influence patient adherence and persistence. Limited real-world evidence exists comparing these outcomes across treatments for multiple sclerosis (...
Retinal atrophy in multiple sclerosis is similar with extended versus standard interval natalizumab therapy [0.03%]
那他珠单抗延长与标准间隔治疗多发性硬化视网膜变性情况相似
Brenna McCormack,Omar Ezzedin,Ting-Yi Lin et al.
Brenna McCormack et al.
Background: Retinal ganglion cell + inner plexiform layer (GCIPL) atrophy reflects global neurodegeneration and disability in multiple sclerosis. Extended interval dosing (EID; every 5-8 weeks) natalizumab reduces progres...
Effectiveness of a digital health application (levidex) on quality of life in people with multiple sclerosis: A pragmatic, randomized controlled trial (LAMONT) [0.03%]
一种数字健康应用程序（levidex）对多发性硬化症患者生活质量的影响：一项务实、随机对照试验(LAMONT)
Björn Meyer,Gereon Nelles,Linda Betz et al.
Björn Meyer et al.
Background: People with multiple sclerosis (pwMS) often experience impaired quality of life (QoL) despite receiving standard care. Digital therapeutics (DTx) may offer support, but prior trials yielded mixed results, poss...
Family planning and multiple sclerosis - Part 1: Patient perspectives on treatment choices in Sweden [0.03%]
从患者角度出发探讨瑞典的计划生育与多发性硬化症（上）：治疗选择
Alejandra Machado,Emma Pettersson,Fitsum Sebsibe Teni et al.
Alejandra Machado et al.
Background and objectives: Family planning and treatment management in women with multiple sclerosis (MS) require complex decision-making. In most cases, patients express their intention to start a family, giving physicia...
Anti-CD20 associated enterovirus meningoencephalitis: A narrative review with two illustrative cases [0.03%]
抗CD20相关肠道病毒脑炎：两例病例的叙事性回顾分析
Kedar R Mahajan,Frank Bittner,Mary Alissa Willis et al.
Kedar R Mahajan et al.
Background: B-cell depleting therapies are used for MS, autoimmune disorders, renal disease and hematological malignancies but increase infection susceptibility. ...
Family planning and multiple sclerosis - part 2: Does real-world practice align with Swedish treatment guidelines? [0.03%]
关于预防接种与多发性硬化症第二部分：瑞典治疗指南中的家庭计划真的管用吗？
Alejandra Machado,Emma Pettersson,Fitsum Sebsibe Teni et al.
Alejandra Machado et al.
Background and objectives: Managing family planning and treatment in women with multiple sclerosis (MS) requires balancing disease control with medication safety. Despite guidelines, practice often adapts to individual ne...
Insights from a Danish nationwide implementation of patient-reported outcomes in multiple sclerosis [0.03%]
丹麦全国实施多发性硬化症患者报告结果的启示
Rolf Pringler Holm,Luigi Pontieri,Mie Reith Mahler et al.
Rolf Pringler Holm et al.
Background: Multiple sclerosis (MS) monitoring often relies on traditional methods like the expanded disability status scale (EDSS) and magnetic resonance imaging, which may not fully reflect patients' health. Patient-rep...
Circulating microRNA expression profiles as biomarkers of disease activity in multiple sclerosis [0.03%]
循环microRNA表达谱作为多发性硬化病活动性的生物标志物
Ifat Vigiser,Yoav Zeevi,Yoav Piura et al.
Ifat Vigiser et al.
Background: Reliable biomarkers of inflammatory activity in multiple sclerosis (MS) are needed to complement clinical and MRI assessments. Circulating microRNAs (miRNAs) are promising candidates due to their serum stabili...
Establishing demographic-based normative values for neurofilament light chain and glial fibrillary acidic protein in serum and plasma samples [0.03%]
基于人口统计学的血清和血浆神经丝轻链和胶质纤维酸性蛋白正常值的确立
Tyler L Borko,Alanna Ritchie,Sean Selva et al.
Tyler L Borko et al.
Background: Interpretation of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) levels in blood requires reference ranges from healthy cohorts, accounting for demographic features. ...