Adherence to behavioural interventions in multiple sclerosis: Follow-up meeting report (AD@MS-2) [0.03%]
多发性硬化行为干预依从性研讨会第二次会议报告(AD@MS-2)
Christoph Heesen,Jared Bruce,Robert Gearing et al.
Christoph Heesen et al.
After an initial meeting in 2013 that reviewed adherence to disease modifying therapy, the AD@MS group conducted a follow-up meeting in 2014 that examined adherence to behavioural interventions in MS (e.g. physical activity, diet, psychosoc...
Effects of a DVD-delivered exercise intervention on physical function in older adults with multiple sclerosis: A pilot randomized controlled trial [0.03%]
一项针对多发性硬化症老年患者的基于DVD的锻炼干预对患者身体功能影响的试点随机对照试验
Edward McAuley,Thomas R Wójcicki,Yvonne Charlotte Learmonth et al.
Edward McAuley et al.
Background: Older adults with multiple sclerosis (MS) exhibit disease-related impairments such as compromised strength, balance, mobility, coordination, and quality of life (QOL). Exercise training as an intervention to r...
Safety, tolerability and pharmacodynamics of a novel immunomodulator, MIS416, in patients with chronic progressive multiple sclerosis [0.03%]
新型免疫调节剂MIS416治疗慢性进展性多发性硬化症的安全性和耐受性及其药理动力学研究
Alison M Luckey,Tim Anderson,Michael H Silverman et al.
Alison M Luckey et al.
Background: Preclinical studies have demonstrated that MIS416, a bacterially derived immune modulator, targets myeloid cells following systemic delivery. MIS416 stimulated myeloid cells have the capacity to regulate innat...
Personalized activity index, a new safety monitoring tool for multiple sclerosis clinical trials [0.03%]
个性化的活动指数，一种新的多发性硬化症临床试验安全监测工具
Yinshan Zhao,Yumi Kondo,Anthony Traboulsee et al.
Yinshan Zhao et al.
Background: An abnormal increase of contrast-enhancing lesion (CEL) counts on frequent MRIs is interpreted as a signal of potential worsening in multiple sclerosis (MS) clinical trials. We demonstrate the utility of the M...
The relationship between objective parameters of sleep and measures of fatigue, depression, and cognition in multiple sclerosis [0.03%]
客观睡眠参数与多发性硬化症疲劳、抑郁和认知评估的关系
R A Sater,M Gudesblatt,K Kresa-Reahl et al.
R A Sater et al.
Background: People with multiple sclerosis (MS) often report poor sleep, fatigue, sleepiness, depression and cognitive dysfunction. Interrelationships between symptoms and sleep are poorly understood. ...
MSJ-ETC Editorial [0.03%]
MSJ-ETC编辑室
Jeffrey Cohen,Ho Jin Kim,Mar Tintore et al.
Jeffrey Cohen et al.
Efficacy and tolerability of oral versus injectable disease-modifying therapies for multiple sclerosis in clinical practice [0.03%]
口服与注射型疾病修正疗法治疗多发性硬化症的疗效和耐受性临床实践的差异
Erin E Longbrake,Anne H Cross,Amber Salter
Erin E Longbrake
Background: The advent of oral disease-modifying therapies fundamentally changed the treatment of multiple sclerosis. Nevertheless, impressions of their relative efficacy and tolerability are primarily founded on expert o...
Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance [0.03%]
富马酸二甲酯相关淋巴细胞减少的风险因素及临床意义
Erin E Longbrake,Robert T Naismith,Becky J Parks et al.
Erin E Longbrake et al.
Background: Dimethyl fumarate (DMF), a disease-modifying therapy for multiple sclerosis (MS), causes lymphopenia in a fraction of patients. The clinical significance of this is unknown. Several cases of progressive multif...
Multiple sclerosis greatly impacts family members/partners: Evidence using the Family Reported Outcome Measure (FROM-16) [0.03%]
家庭报告结果测量表(FROM-16)显示多发性硬化症对家庭成员/伴侣影响巨大
Background: Multiple sclerosis (MS) may have a major impact on the physical, social and psychological wellbeing of people with multiple sclerosis (pwMS) and their family members/partners. ...