Geographic variations of multiple sclerosis prevalence in France: The latitude gradient is not uniform depending on the socioeconomic status of the studied population [0.03%]
法国多发性硬化患病率的地理差异：纬度梯度因研究人群的社会经济地位不同而不均匀
Philippe Ha-Vinh,Stève Nauleau,Marine Clementz et al.
Philippe Ha-Vinh et al.
Background: In France, two studies analysed multiple sclerosis prevalence nationwide: one was carried out in farmers, and the other one in employees. A south-north gradient of prevalence was found solely in farmers. ...
Negative prognostic impact of MRI spinal lesions in the early stages of relapsing-remitting multiple sclerosis [0.03%]
复发缓解型多发性硬化症早期阶段磁共振脊髓病变的不良预后影响
E D&#x;Amico,F Patti,C Leone et al.
E D&#x;Amico et al.
Background: The presence of spinal cord (SC) magnetic resonance imaging (MRI) lesions can be expected to affect the mobility of people with relapsing-remitting MS (pwRRMS), but reports are ambiguous. ...
Myelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin [0.03%]
髓鞘少突胶质细胞糖蛋白在针对中枢神经系统髓鞘的T细胞自身免疫中的双重作用
Bert A &#x;t Hart,Robert Weissert
Bert A &#x;t Hart
Background: Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has b...
Longitudinal analyses of anti-JCV antibody index for risk assessment of progressive multifocal leukoencephalopathy [0.03%]
抗JCV抗体指数的纵向分析在进行进展性多灶性白质脑病风险评估中的应用
A Salmen,N von Ahsen,A K Trampe et al.
A Salmen et al.
Risk assessment for natalizumab-associated progressive multifocal leukoencephalopathy (Nat-PML) comprises the anti-JC virus (JCV) antibody index (AI). The anti-JCV AI was longitudinally determined in a natalizumab-treated MS cohort (Nat-MS,...
Jeffrey A Cohen,Ho Jin Kim,Mar Tintore
Jeffrey A Cohen
Incidence of AQP4-IgG seropositive neuromyelitis optica spectrum disorders in the Netherlands: About one in a million [0.03%]
荷兰国家人群中的水通道蛋白4-IgG阳性神经脊髓炎谱系疾病患病率约为百万分之一
E Daniëlle van Pelt,Yu Yi M Wong,Immy A Ketelslegers et al.
E Daniëlle van Pelt et al.
Neuromyelitis optica (NMO) is a rare autoimmune disease affecting the optic nerves and spinal cord. In the majority of NMO patients anti-aquaporin-4 antibodies (AQP4-IgG) are detected. Here we assessed a nationwide incidence of AQP4-IgG-ser...
Predicting optimal response to B-cell depletion with rituximab in multiple sclerosis using CXCL13 index, magnetic resonance imaging and clinical measures [0.03%]
使用CXCL13指数、磁共振成像和临床指标预测利妥昔单抗治疗多发性硬化症的最优反应
Enrique Alvarez,Laura Piccio,Robert J Mikesell et al.
Enrique Alvarez et al.
Background: B-cell depleting drugs show promise for treating multiple sclerosis. Objective: We sought predictors of optimal response to...
Improvement to baseline after plasma exchange in spinal attacks associated with neuromyelitis optica [0.03%]
与视神经脊髓炎相关的脊髓发作在血浆置换治疗后的改善状况评估
Mickael Bonnan,Philippe Cabre
Mickael Bonnan
Free kappa light chains in cerebrospinal fluid as a biomarker to assess risk conversion to multiple sclerosis [0.03%]
脑脊液中游离κ轻链作为生物标志物评估多发性硬化症风险的转换
P Menéndez-Valladares,M I García-Sánchez,P Cuadri Benítez et al.
P Menéndez-Valladares et al.
Background: Multiple sclerosis (MS) initiates with a first attack or clinically isolated syndrome (CIS). The importance of an early treatment in MS leads to the search, as soon as possible, for novel biomarkers which can ...
A randomized trial of teriflunomide added to glatiramer acetate in relapsing multiple sclerosis [0.03%]
特立氟咪酯与醋酸格拉默联合治疗复发性多发性硬化症的随机临床试验
M S Freedman,J S Wolinsky,P Truffinet et al.
M S Freedman et al.
Background: Teriflunomide is a once-daily oral immunomodulator for the treatment of relapsing-remitting MS. Objective: To evaluate the ...