Association of multiple sclerosis and sudden sensorineural hearing loss [0.03%]
多发性硬化症与突发性感音神经性听力损失的相关性
S Atula,S T Sinkkonen,R Saat et al.
S Atula et al.
Background: Multiple sclerosis (MS) may affect other cranial nerves besides the optic nerve. Sudden sensorineural hearing loss (SSHL), possibly caused by a deficit in the auditory tract, including the vestibulocochlear ne...
Erythrocytes in multiple sclerosis - forgotten contributors to the pathophysiology? [0.03%]
多发性硬化症中的红细胞——被遗忘的病理生理学贡献者吗？
Kira Groen,Vicki E Maltby,Katherine A Sanders et al.
Kira Groen et al.
Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environm...
Burden of genetic risk variants in multiple sclerosis families in the Netherlands [0.03%]
荷兰多发性硬化家系的遗传风险变异负担
Julia Y Mescheriakova,Linda Broer,Simin Wahedi et al.
Julia Y Mescheriakova et al.
Background: Approximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive. ...
The Neurological Sleep Index: A suite of new sleep scales for multiple sclerosis [0.03%]
神经睡眠指数：一套新的多发性硬化症睡眠量表
R J Mills,A Tennant,C A Young
R J Mills
Objective: The objective of this study was to develop patient-reported outcome measures for sleep dysfunction and sleepiness in multiple sclerosis (MS), since there are currently no MS-specific measurement tools for these...
Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve [0.03%]
遗传学方法体内抑制LINGO-1可减少视神经退行性变并促进其再生
Melissa M Gresle,Yaou Liu,Trevor J Kilpatrick et al.
Melissa M Gresle et al.
Background: Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Acr...
Phu D Hoang,Meryem Baysan,Hilary Gunn et al.
Phu D Hoang et al.
Introduction: The Physiological Profile Assessment (PPA) is used in research and clinical practice for assessing fall risk. We compared PPA test performance between people with multiple sclerosis (MS) and healthy controls...
Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression [0.03%]
常见的可遗传的血液免疫细胞群差异可能是多发性硬化易感性和进展的基础
David R Booth,Nicole L Fewings,Grant P Parnell et al.
David R Booth et al.
A promising new avenue of MS research that may lead to a better understanding of pathogenesis, progression and therapeutic response, and to development of new therapies, comes from the recent identification of defined immune cell population...
Accuracy and precision of smartphone applications and commercially available motion sensors in multiple sclerosis [0.03%]
智能手机应用程序和商用运动传感器在多发性硬化症患者中的准确性和精确度
Julia M Balto,Dominique L Kinnett-Hopkins,Robert W Motl
Julia M Balto
Background: There is increased interest in the application of smartphone applications and wearable motion sensors among multiple sclerosis (MS) patients. ...
Delayed-release dimethyl fumarate and disability assessed by the Multiple Sclerosis Functional Composite: Integrated analysis of DEFINE and CONFIRM [0.03%]
延缓释放富马酸二甲酯和由多发性硬化症功能复合评估的残疾状况：DEFINE研究与CONFIRM研究整合分析
Gavin Giovannoni,Ralf Gold,Ludwig Kappos et al.
Gavin Giovannoni et al.
The effect of delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on the Multiple Sclerosis Functional Composite (MSFC) was assessed using integrated Phase 3 DEFINE and CONFIRM data. Patients treated with DMF (n = 76...
Comparison of nadir serum concentrations in the extended dosing therapy of natalizumab between American and Japanese multiple sclerosis patients [0.03%]
纳利珠单抗延长给药疗程在美国和日本多发性硬化患者中达到稳态时的谷浓度比较研究
Masami Tanaka,Kaho Yokoyama
Masami Tanaka