Thrombin generation correlates with disease duration in multiple sclerosis (MS): Novel insights into the MS-associated prothrombotic state [0.03%]
血栓调节蛋白的生成与多发性硬化病程相关：关于多发性硬化相关促凝状态的新观点
Martin Em Parsons,Karen O&#x;Connell,Seamus Allen et al.
Martin Em Parsons et al.
Background: Thrombin is well recognised for its role in the coagulation cascade but it also plays a role in inflammation, with enhanced thrombin generation observed in several inflammatory disorders. Although patients wit...
Interferon beta-1b in treatment-naïve paediatric patients with relapsing-remitting multiple sclerosis: Two-year results from the BETAPAEDIC study [0.03%]
β干扰素-β-1b在小儿复发型多发性硬化症初治患者中的疗效：BETAPAEDIC研究的两年结果
Jutta Gärtner,Wolfgang Brück,Almuth Weddige et al.
Jutta Gärtner et al.
Background and objective: Study evaluating Betaferon(R)'s safety and tolerability in paediatric patients with multiple sclerosis (BETAPAEDIC) is a prospective, open-label observational multicentre study to assess the safe...
Subcutaneous interferon β-1a three times weekly and the natural evolution of gadolinium-enhancing lesions into chronic black holes in relapsing and progressive multiple sclerosis: Analysis of PRISMS and SPECTRIMS trials [0.03%]
重组干扰素β-1a皮下注射每周三次与复发型多发性硬化症及进行性多发性硬化症患者中钆增强病灶的自然演变成为慢性黑灶：PRISMS和SPECTRIMS试验分析
A Traboulsee,Dkb Li,R Tam et al.
A Traboulsee et al.
Background: Evolution of gadolinium-enhancing lesions into chronic black holes (CBH) may be reduced by interferon (IFN) therapy. Objective: ...
Randomized, Placebo-controlled Crossover Study of Dalfampridine Extended-release in Transverse Myelitis [0.03%]
延髓炎患者使用盐酸达氟米idine缓释片的随机双盲对照交叉研究
Kateryna Schwartz,Nicholas F Wymbs,Hwa Huang et al.
Kateryna Schwartz et al.
Background: Dalfampridine has the potential to be effective in patients with transverse myelitis (TM) as this rare disorder shares some clinical and pathogenic similarities with multiple sclerosis. ...
Serum Neurofilament Light Chain in NMOSD and Related Disorders: Comparison According to Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Antibodies Status [0.03%]
NMOSD及相关疾病血清神经丝轻链根据AQP4和MOG抗体状态的比较
Mariotto S,Farinazzo A,Monaco S et al.
Mariotto S et al.
Background: Neurofilament light chain (NF-L) levels reflect axonal damage in different conditions, including demyelinating disorders. Objectives: ...
Antibody response against HERV-W env surface peptides differentiates multiple sclerosis and neuromyelitis optica spectrum disorder [0.03%]
针对HERV-W_env表面肽的抗体反应可区分多发性硬化和视神经脊髓炎谱系疾病
Giannina Arru,Elia Sechi,Sara Mariotto et al.
Giannina Arru et al.
Background: A specific humoral immune response against HERV-W envelope surface (env-su) glycoprotein antigens has been reported in serum of patients with multiple sclerosis (MS). However, it has not been evaluated to date...
Measuring the impact of multiple sclerosis: Enhancing the measurement performance of the Multiple Sclerosis Impact Scale (MSIS-29) using Rasch Measurement Theory (RMT) [0.03%]
用拉什测量理论增强多发性硬化症影响量表的测量性能
Sophie Cleanthous,Stefan Cano,Elizabeth Kinter et al.
Sophie Cleanthous et al.
Background: Study objectives were to evaluate the Multiple Sclerosis Impact Scale (MSIS-29) and explore an optimized scoring structure based on empirical post-hoc analyses of data from the Phase III ADVANCE clinical trial...
Randomized controlled trial of an e-learning designed behavioral intervention for increasing physical activity behavior in multiple sclerosis [0.03%]
多发性硬化症患者增加体力活动行为的基于网络的行为干预的随机对照试验
Robert W Motl,Elizabeth A Hubbard,Rachel E Bollaert et al.
Robert W Motl et al.
Background: Internet-delivered, behavioral interventions represent a cost-effective, broadly disseminable approach for teaching persons with multiple sclerosis (MS) the theory-based skills, techniques, and strategies for ...
Prevalence of neutralising antibodies to interferon-beta and clinical response in Chinese patients with relapsing multiple sclerosis [0.03%]
中国复发性多发性硬化症患者干扰素β中和抗体的流行率及其临床反应
Alexander Y Lau,W K Ip,Cheryl Au et al.
Alexander Y Lau et al.
Background: There are no data on neutralising antibodies to interferon-beta and its clinical implications in Chinese patients with multiple sclerosis (MS). ...
The efficacy of cladribine tablets in CIS patients retrospectively assigned the diagnosis of MS using modern criteria: Results from the ORACLE-MS study [0.03%]
克拉屈滨片对后来根据现代标准确诊为多发性硬化症的单时相临床孤立综合征患者的有效性：ORACLE-MS研究结果
Mark S Freedman,Thomas P Leist,Giancarlo Comi et al.
Mark S Freedman et al.
Background: Multiple sclerosis (MS) diagnostic criteria have changed since the ORACLE-MS study was conducted; 223 of 616 patients (36.2%) would have met the diagnosis of MS vs clinically isolated syndrome (CIS) using the ...