Relapse Rate and MRI Activity in Young Adult Patients With Multiple Sclerosis: A Post Hoc Analysis of Phase 3 Fingolimod Trials [0.03%]
青年多发性硬化症患者的复发率和磁共振成像活性：芬戈莫德三期临床试验的事后分析
Jutta Gärtner,Tanuja Chitnis,Angelo Ghezzi et al.
Jutta Gärtner et al.
Background: Disease activity differs in young patients with multiple sclerosis (MS) compared with the overall adult MS population. Objective: ...
Patient-Reported Disease-Modifying Therapy Adherence in the Clinic: A Reliable Metric? [0.03%]
患者报告的疾病修正疗法在临床上的一致性：一种可靠的指标吗？
Devon S Conway,Maria Cecilia Vieira,Nicolas R Thompson et al.
Devon S Conway et al.
Background: Adherence to multiple sclerosis (MS) disease-modifying therapy (DMT) is commonly assessed through patient reporting, but patient-reported adherence is rarely studied. ...
Addressing the targeting range of the ABILHAND-56 in relapsing-remitting multiple sclerosis: A mixed methods psychometric study [0.03%]
一种混合方法心理测量研究：在复发缓解型多发性硬化症中解决ABILHAND-56的目标范围问题
Sophie Cleanthous,Sara Strzok,Farrah Pompilus et al.
Sophie Cleanthous et al.
Background: ABILHAND, a manual ability patient-reported outcome instrument originally developed for stroke patients, has been used in multiple sclerosis clinical trials; however, psychometric analyses indicated the measur...
Clinical efficacy of teriflunomide over a fixed 2-year duration in the TOWER study [0.03%]
TOWER研究中特立氟宁固定2年治疗期的临床疗效分析
Mark S Freedman,Julia Morawski,Karthinathan Thangavelu
Mark S Freedman
Patients enrolled in the phase 3 TOWER study (NCT00751881) of teriflunomide had variable treatment durations (48-173 weeks). This has led to challenges when interpreting results in the context of other phase 3 trials of disease-modifying th...
The Sound of Jacqueline du Pré: Revisiting her Medical and Musical History [0.03%]
倾听杰奎琳·杜普蕾的声音——重新审视她的医学和音乐史
Luis Octavio Tierradentro-García,Juan Sebastián Botero-Meneses,Claudia Talero-Gutiérrez
Luis Octavio Tierradentro-García
Jacqueline du Pré was a British cellist, famous for her masterful interpretations and her passionate style of playing. Her outstanding musical career was, unfortunately, cut short by multiple sclerosis. In the present paper, we conduct a h...
Myelin status is associated with change in functional mobility following slope walking in people with multiple sclerosis [0.03%]
脱髓鞘状态与多发性硬化患者斜坡行走后功能移动性变化有关
E M King,M J Sabatier,M Hoque et al.
E M King et al.
Background: The level of myelin disruption in multiple sclerosis patients may impact the capacity for training-induced neuroplasticity and the magnitude of therapeutic response to rehabilitation interventions. Downslope w...
A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study [0.03%]
窄带紫外线B光疗治疗临床孤立综合征的随机对照临床试验：PhoCIS研究
Prue H Hart,Anderson P Jones,Stephanie Trend et al.
Prue H Hart et al.
Background: The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode of neurological symptoms caused by central nervous system inflammation or demyelination...
Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis [0.03%]
热休克蛋白70作为炎症性疾病的生物标志物在多发性硬化动物模型中的作用研究
Patricia Lechner,Dorothea Buck,Lisa Sick et al.
Patricia Lechner et al.
Background: Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation. ...
Multiple sclerosis: Executive dysfunction, task switching and the role of attention [0.03%]
多发性硬化症：执行功能障碍、任务转换和注意的作用
M Clough,P Foletta,A N Frohman et al.
M Clough et al.
Background: It has been suggested that switching ability might not be affected in multiple sclerosis (MS) as previously thought; however, whether this is true under more 'real-world' conditions when asymmetry in task diff...
Coexistence of systemic lupus erythematosus and multiple sclerosis. A case report and literature review [0.03%]
系统性红斑狼疮与多发性硬化病并存的一个病例报告和文献复习
Elisa Carolina Jácome Sánchez,María Ariana García Castillo,Victor Paredes González et al.
Elisa Carolina Jácome Sánchez et al.
Multiple sclerosis (MS) and systemic lupus erythematous (SLE) are autoimmune diseases, the coexistence of which is uncommon in patients. Owing to the rarity of this condition, the distinction between MS and SLE is a diagnostic challenge for...