Clinical relevance and predictors of anti-natalizumab antibodies in multiple sclerosis: A real-world retrospective cohort study [0.03%]
针对多发性硬化症患者抗那他珠单抗抗体的临床相关性和预测因素：一项回顾性队列研究
Michael Levy,Ysoline Beigneux,Thomas Roux et al.
Michael Levy et al.
Background: Natalizumab is effective for relapsing MS but may trigger anti-natalizumab antibodies (ANZ) that neutralise drug activity and increase reactions. Trials report persistent antibodies in ∼6% and overall prevale...
The interconnection of multiple sclerosis and neurofibromatosis type 1: A single institution retrospective study and systematic review [0.03%]
多发性硬化与1型神经纤维瘤病的关联：单一机构回顾性研究及系统综述
Danielle A Bazer,Grace E Tobin,Nyah Woller-Li et al.
Danielle A Bazer et al.
Background: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic neurocutaneous disorder. Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. The rates of occurre...
Characteristics of myelin oligodendrocyte glycoprotein antibody-associated meningoencephalitis [0.03%]
髓鞘少突胶质细胞糖蛋白抗体相关脑炎的临床特征分析
Aisha Elfasi,Samir Alkabie,Elsa Rodriguez et al.
Aisha Elfasi et al.
Background: Meningoencephalitis can occur in myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). Objective: ...
Safety and efficacy of extended versus standard interval dosing of anti-CD20 therapy in multiple sclerosis - A meta-analysis [0.03%]
延长与标准间隔给药的抗CD20疗法治疗多发性硬化症的安全性和有效性——一项荟萃分析
Mahmoud Elkhooly,Rhea Jacob,Torge Rempe
Mahmoud Elkhooly
Background: Anti-CD20 therapy is a highly effective multiple sclerosis (MS) disease-modifying therapy, but may be complicated by infections, which has led to the utilization of different extended interval dosing (EID) reg...
Vlad C Bibic,Robert Carruthers,Daniel Hong et al.
Vlad C Bibic et al.
Background: Aggressive multiple sclerosis (MS) causes early, rapid accumulation of disability with frequent and severe relapses, incomplete recovery from relapses, and/or high T2 lesion burden. Severe relapses are typical...
Use of optical coherence tomography in the care of people with multiple sclerosis in Switzerland: A national survey among neurologists [0.03%]
光学相干断层扫描在瑞士多发性硬化患者护理中的应用：神经科医生的全国调查
Veronika Kana,Marina Herwerth,Konstantin Gugleta et al.
Veronika Kana et al.
Background: Optical coherence tomography (OCT) can assess optic nerve involvement and facilitate the diagnosis of multiple sclerosis (MS). Objective: ...
Real-world safety and effectiveness of ofatumumab in multiple sclerosis: A clinic-based study in Australia [0.03%]
奥法木单抗治疗多发性硬化症的现实世界安全性和有效性：一项在澳大利亚进行的基于门诊患者的临床研究
Turlough Montague,Emily Cheung,Yuuki Kang et al.
Turlough Montague et al.
Background: Monoclonal antibodies that target the CD20 antigen and cause B-cell depletion have proven to be a highly effective treatment strategy in relapsing-remitting MS (RRMS). Ofatumumab, the first fully human anti-CD...
In multiple sclerosis, cognitive disengagement syndrome (CDS) is associated with higher depression, insomnia, fatigue, and paresthesia [0.03%]
在多发性硬化症中，认知脱离综合征(CDS)与更高的抑郁、失眠、疲劳和感觉异常有关
Dena Sadeghi-Bahmani,G Leornard Burns,Atefeh Meghrazi et al.
Dena Sadeghi-Bahmani et al.
Background: Cognitive disengagement syndrome (CDS) refers to a set of attentional symptoms comprising daydreaming, mental fogginess, and hypoactivity clearly distinguishable from ADHD-IN and other forms of psychopathologi...
Diagnostic pathways and barriers in multiple sclerosis in Zambia: A qualitative study [0.03%]
赞比亚多发性硬化症的诊断途径和障碍：一项定性研究
Mashina Chomba,Dominique Mortel,Sarah Braun et al.
Mashina Chomba et al.
Background: Multiple sclerosis remains under-recognized in Zambia and much of sub-Saharan Africa, often leading to misdiagnosis and delays. Understanding diagnostic pathways and barriers can inform strategies to improve m...
Baricitinib triggering a central nervous system inflammatory-demyelinating disease: A case report [0.03%]
巴瑞克替尼诱发中枢神经系统炎症脱髓鞘疾病1例报告
Rozita Khalili,Ahmad A Toubasi,Meryim Poursheykhi et al.
Rozita Khalili et al.
Janus kinase inhibitors (JAKis), such as baricitinib, target the Janus kinase/signal transducers and activators of transcription pathway to regulate proinflammatory cytokines and T-helper cell activity, thereby reducing inflammation. Despit...