Tumefactive demyelination: Clinical outcomes, lesion evolution and treatments [0.03%]
肿瘤样脱髓鞘的临床预后、病灶演变和治疗方法
Staley A Brod,J William Lindsey,Flavia Nelson
Staley A Brod
Objective: Large demyelinating lesions with possible mass effect (tumefactive multiple sclerosis or tumefactive demyelination) can be mistaken for tumour-like space-occupying lesions suggesting a malignant outcome. ...
Exploratory MRI measures after intravenous autologous culture-expanded mesenchymal stem cell transplantation in multiple sclerosis [0.03%]
静脉注射扩增的自体间充质干细胞治疗多发性硬化症的探索性磁共振检测措施研究
Jenny Feng,Erik Offerman,Jian Lin et al.
Jenny Feng et al.
Background: Mesenchymal stem cells (MSC) have immunomodulatory and neuro-protective properties and are being studied for treatment of multiple sclerosis (MS). Tractography-based diffusion tensor imaging (DTI), cortical th...
Conversion of clinically isolated syndrome to multiple sclerosis: a prospective multi-center study in Eastern India [0.03%]
临床孤立综合征患者向多发性硬化的转化：印度东部多中心前瞻性研究
T K Banerjee,M Saha,E Ghosh et al.
T K Banerjee et al.
Background: In White populations more than 60% of clinically isolated syndrome (CIS) convert to multiple sclerosis (MS) on a long-term follow-up; several predictors for conversion have been identified. ...
No differential gene expression for CD4+ T cells of MS patients and healthy controls [0.03%]
多发性硬化症患者和健康对照者CD4+t细胞无差异表达基因
Ina S Brorson,Anna Eriksson,Ingvild S Leikfoss et al.
Ina S Brorson et al.
Background: Multiple sclerosis-associated genetic variants indicate that the adaptive immune system plays an important role in the risk of developing multiple sclerosis. It is currently not well understood how these multi...
Efficacy and safety of dimethyl fumarate in treatment-naïve Japanese patients with multiple sclerosis: Interim analysis of the randomized placebo-controlled study [0.03%]
富马酸二甲酯治疗日本初治多发性硬化患者的疗效和安全性：随机双盲安慰剂对照研究的中期分析结果
Masahiro Mori,Takashi Ohashi,Yasuhiro Onizuka et al.
Masahiro Mori et al.
Background: The use of dimethyl fumarate has not been reported in treatment-naïve Japanese patients with relapsing-remitting multiple sclerosis. Objectiv...
Perception of stigma in patients with primary progressive multiple sclerosis [0.03%]
原发进展型多发性硬化症患者的耻辱感知研究
Francisco Pérez-Miralles,Daniel Prefasi,Antonio García-Merino et al.
Francisco Pérez-Miralles et al.
Stigma associated with neurological disorders may contribute to a poor health-related quality of life. However, limited information is available in primary progressive multiple sclerosis. We investigated the presence and impact of stigma in...
Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial [0.03%]
一项关于口服硫辛酸治疗急性视神经炎的盲法、安慰剂对照随机试验
Julie Falardeau,Allison Fryman,Rohan Wanchu et al.
Julie Falardeau et al.
Background: Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representi...
Distinct serum and cerebrospinal fluid cytokine and chemokine profiles in autoantibody-associated demyelinating diseases [0.03%]
自身抗体相关脱髓鞘疾病的血清和脑脊液细胞因子及趋化因子谱不同
Livia S Hofer,Sara Mariotto,Sebastian Wurth et al.
Livia S Hofer et al.
Background: Demyelinating diseases of the central nervous system associated with autoantibodies against aquaporin-4 and myelin-oligodendrocyte-glycoprotein are mediated by different immunopathological mechanisms compared ...
Multicentre assessment of motor and sensory evoked potentials in multiple sclerosis: reliability and implications for clinical trials [0.03%]
多发性硬化症的运动和感觉诱发电位的多中心评估：可靠性及对临床试验的影响
Martin Hardmeier,François Jacques,Philipp Albrecht et al.
Martin Hardmeier et al.
Background: Motor and sensory evoked potentials (EP) are potential candidate biomarkers for clinical trials in multiple sclerosis. Objective: ...
The Multiple Sclerosis Functional Composite and Symbol Digit Modalities Test as outcome measures in pediatric multiple sclerosis [0.03%]
儿童多发性硬化症功能复合体和符号数字模式测试作为结果测量指标
J Nicholas Brenton,Hitoshi Koshiya,Emma Woolbright et al.
J Nicholas Brenton et al.
Background: There is an increasing number of pediatric multiple sclerosis (MS) clinical trials occurring; however, data validating outcome metrics that accurately capture functional disability within pediatric cohorts are...