Pharmaceutical studies on and clinical application of olanzapine suppositories prepared as a hospital preparation [0.03%]
奥氮平栓的药学研究及临床应用
Kazuaki Matsumoto,Satoru Kimura,Kenichi Takahashi et al.
Kazuaki Matsumoto et al.
Background: A new formulation of olanzapine available for terminally ill patients is needed. Rectal administration using suppositories is an alternative for patients for whom administration via the oral route is not feasi...
Evaluation of pharmaceutical lifesaving skills training oriented pharmaceutical intervention [0.03%]
基于药学干预的救命技能训练效果评价
Yoshito Zamami,Toru Imai,Masaki Imanishi et al.
Yoshito Zamami et al.
Background: Many pharmacists are participating in team-based medical care in emergency hospitals. Therefore, there is a desperate need to improve the education system. In the present study, we provided a "pharmaceutical l...
Predictors of the therapeutic effect of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome [0.03%]
全身性炎症反应综合征相关急性肺损伤患者使用西维莱司特疗效的影响因素分析
Takuma Ozawa,Kiyoshi Mihara,Nobuhiro Yasuno
Takuma Ozawa
Background: Sivelestat, a neutrophil elastase inhibitor, was previously approved in Japan for the treatment of acute lung injury associated with systemic inflammatory response syndrome. However, sivelestat produced incons...
Pharmacokinetics and dose adjustment of etoposide administered in a medium-dose etoposide, cyclophosphamide and total body irradiation regimen before allogeneic hematopoietic stem cell transplantation [0.03%]
中剂量依托泊苷、环磷酰胺及全身放疗方案用于异基因外周血造血干细胞移植前清髓的药代动力学及剂量调整研究
Yuki Tazawa,Akio Shigematsu,Kumiko Kasashi et al.
Yuki Tazawa et al.
Background: We investigated the pharmacokinetics of etoposide (ETP) to reduce the inter-individual variations of ETP concentrations in patients with acute leukemia who underwent allogeneic hematopoietic stem cell transpla...
Effect of vitamin K2 on the anticoagulant activity of warfarin during the perioperative period of catheter ablation: Population analysis of retrospective clinical data [0.03%]
维生素K2对导管消融围手术期-warfarin抗凝活性的影响：一项回顾性临床数据分析
Zhi Zhou,Ikuko Yano,Sumiko Odaka et al.
Zhi Zhou et al.
Background: Catheter ablation is a non-medication therapy for atrial fibrillation, and during the procedure, warfarin is withdrawn in the preoperative period to prevent the risk of bleeding. In case of emergency, vitamin ...
Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population [0.03%]
与化疗引起的恶心和呕吐相关的多态性在日本人群中的基因型频率分布特征
Aya Goto,Haruka Kotani,Masayuki Miyazaki et al.
Aya Goto et al.
Background: Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects. ...
Elevated prothrombin time/international normalized ratio associated with concurrent administration of regorafenib and warfarin in a patient with advanced colorectal cancer [0.03%]
一例接受瑞戈非尼和华法林联合治疗的晚期结直肠癌患者的凝血酶原时间/国际标准化比率升高病例报告
Hironori Kitade,Azusa Hiromasa-Yamasaki,Kengo Hokkoku et al.
Hironori Kitade et al.
Background: Regorafenib and its metabolites may inhibit the activities of several CYP or UDP-glucuronosyltransferase isoforms, including that of CYP2C9. Therefore, pharmacological agents that are CYP2C9 substrates may sho...
Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis using the Japanese Adverse Drug Event Report database [0.03%]
利用日本药物不良事件报告数据库分析史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症
Junko Abe,Ryogo Umetsu,Kanako Mataki et al.
Junko Abe et al.
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions associated with fatal disorders. Although many causes of SJS/TEN have been proposed, the time-to-onset...
Preliminary study for predicting better methotrexate efficacy in Japanese patients with rheumatoid arthritis [0.03%]
预测日本类风湿关节炎患者甲氨蝶呤疗效的预测性研究初步报告
Masayuki Hashiguchi,Tomomi Tsuru,Kumika Miyawaki et al.
Masayuki Hashiguchi et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammatory status, joint destruction, disability, and pain. Methotrexate (MTX) has been confirmed to reduce disease activit...
The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study [0.03%]
米安色林直肠栓剂在犬和健康志愿者中的药代动力学：一项试点研究
Shuichi Nawata,Noriko Kohyama,Naoki Uchida et al.
Shuichi Nawata et al.
Background: We formulated mianserin suppositories for the treatment of delirium and evaluated their pharmacokinetics by measuring plasma drug concentrations in dogs and healthy human volunteers. ...