Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting [0.03%]
自动化样品准备模块（CLAM-LC-MS / MS系统）与液相色谱串联质谱的连接验证及其在临床环境中的他克莫司和环孢菌素A定量检测中与常规免疫测定法的比较
Tsutomu Shimada,Daisuke Kawakami,Arimi Fujita et al.
Tsutomu Shimada et al.
Background: Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both methodologies have disadvantages. In this study, we aimed to...
Temporal trends in antipsychotic prescriptions for pediatric patients using an administrative hospital database in Japan: a retrospective study [0.03%]
利用日本医院行政数据库分析儿童抗精神病药物的处方时间变化趋势的一项回顾性研究
Daisuke Kikuchi,Taku Obara,Ryo Obara et al.
Daisuke Kikuchi et al.
Background: Schizophrenia is a psychiatric disorder characterized by hallucinations, delusions, and other symptoms. Although treatment guidelines for schizophrenia have been established in Japan, drugs are not recommended...
Five years of safety profile of bevacizumab: an analysis of real-world pharmacovigilance and randomized clinical trials [0.03%]
贝伐珠单抗五年的安全概况：真实世界药物警戒与随机临床试验的分析
Li Wang,Yibo Fei,Han Qu et al.
Li Wang et al.
Objective: Bevacizumab is a monoclonal antibody against vascular endothelial growth factor. It has a wide range of clinical applications in various cancers and retinal diseases. The drugs entered the Chinese market by a l...
Health-related quality of life and its associated factors among hemophilia patients: experience from Ethiopian Hemophilia Treatment Centre [0.03%]
血友病患者的健康相关生活质量及其相关因素：来自埃塞俄比亚血友病治疗中心的经验
Sitina Iyar,Girma Tekle Gebremariam,Dessale Abate Beyene et al.
Sitina Iyar et al.
Background: Hemophilia is a rare genetic condition that is often overlooked and underdiagnosed, particularly in low-income countries. Long-term spontaneous joint bleeding and soft tissues can have a significant negative i...
A case with a trend of QT interval prolongation due to the introduction of methadone to a pancreatic cancer patient on levofloxacin [0.03%]
左氧氟沙星联用美沙酮致胰腺癌患者QT间期延长一例报告
Ryusuke Ouchi,Munenori Nagao,Shinju Suzuki et al.
Ryusuke Ouchi et al.
Background: As methadone can prevent the development of opioid resistance, it has application in alleviating cancer-related pain that proves challenging to manage with other opioids. QT interval prolongation is a serious ...
Influence of filtering on the effective concentration and sterility of a 2% cyclosporine ophthalmic solution: a quality improvement perspective [0.03%]
过滤对2%环孢素滴眼液的有效浓度和无菌性的影响：质量改进的视角
Masakazu Ozaki,Toshihiko Kobayashi,Aki Fujinaga et al.
Masakazu Ozaki et al.
Background: Pharmaceutical companies do not sell formulations for all diseases; thus, healthcare workers have to treat some diseases by concocting in-hospital preparations. An example is the high-concentration 2% cyclospo...
Impact of HBcrAg levels on HBsAg seroconversion after HBV rebound: a case report [0.03%]
HBV复发后HBcrAg水平对HBsAg血清学转换的影响（病例报告）
Maki Ohkubo,Kuniaki Fukuda,Shigeru Chiba et al.
Maki Ohkubo et al.
Background: Nucleoside analogues (NAs) such as entecavir are required for at least 12 months when patients with resolved hepatitis B virus (HBV) infection develop HBV reactivation. Entecavir treatment does not always achi...
Efficacy of the bleeding risk scoring system for optimal prophylactic anticoagulation therapy of venous thromboembolism in trauma patients: a single-center, retrospective, observational cohort study [0.03%]
出血风险评分系统指导创伤患者最优预防性抗凝血治疗疗效的单中心回顾性观察队列研究
Atsushi Tomizawa,Takaaki Maruhashi,Akito Shibuya et al.
Atsushi Tomizawa et al.
Background: We developed a bleeding risk scoring system (BRSS) using prophylactic anticoagulation therapy to comprehensively assess the risk of venous thromboembolism (VTE) in trauma patients. This study evaluated the use...
Upregulation of brain-derived neurotrophic factor by Shiikuwasha (Citrus depressa Hayata) [0.03%]
shlva(Citrus depressa Hayata)诱导脑源性神经营养因子的表达上调
Kensuke Nakajima,Shinya Okubo,Tomoe Ohta et al.
Kensuke Nakajima et al.
Background: A reduction in the brain-derived neurotrophic factor (BDNF) level in the brain causes depression, whereas an increase in its level has therapeutic benefits against depression. BDNF is synthesized in various pe...
Bleeding risk factors and real-world antithrombotic therapies in elderly patients with atrial fibrillation undergoing percutaneous coronary intervention: a retrospective study [0.03%]
老年房颤患者经皮冠状动脉介入术的出血危险因素及临床抗栓策略：一项回顾性研究
Kanako Fujita,Noriko Kohyama,Miki Sato et al.
Kanako Fujita et al.
Background: Bleeding risk factors in elderly patients with atrial fibrillation undergoing percutaneous coronary intervention (PCI) are unclear and data on the use of antithrombotic drugs are lacking. We investigated the b...