Enhancement of therapeutic efficacy of Brinzolamide for Glaucoma by nanocrystallization and tyloxapol addition [0.03%]
纳米晶技术和Tyloxapol技术改善Brimzolamide治疗青光眼的药效学研究
Shuya Masuda,Shiho Yano,Tomohisa Tadokoro et al.
Shuya Masuda et al.
Background: Brinzolamide (BRI) suspensions are used for the treatment of glaucoma; however, sufficient drug delivery to the target tissue after eye drop administration is hampered by poor solubility. To address this issue...
Evaluation of the drug-drug interactions management system for appropriate use of nirmatrelvir/ritonavir: a retrospective observational study [0.03%]
评价药物相互作用管理系统促进奈玛特韦/利托那韦合理应用的回顾性观察研究
Takeshi Tomida,Takeshi Kimura,Kazuhiro Yamamoto et al.
Takeshi Tomida et al.
Purpose: While nirmatrelvir/ritonavir (NMV-r) has been positioned as a first-line treatment for mild to moderate COVID-19, it has multiple and significant drug-drug interactions (DDIs). The use of NMV-r in Japan has been ...
Patient resuscitated after cardiopulmonary arrest exhibits abnormally increased phenytoin metabolic rate due to unknown factors: a case report [0.03%]
因不明因素心肺复苏后苯妥英代谢率异常增高的脑死亡患者一例报告
Ayumu Nagamine,Takuya Araki,Hideaki Yashima et al.
Ayumu Nagamine et al.
Background: Fosphenytoin (FOS) is a prodrug of phenytoin (PHT) with a metabolism that exhibits Michaelis-Menten-type kinetics. Genetic polymorphisms of the metabolic enzymes of PHT make it challenging to predict its plasm...
Subjective symptoms are triggers for the detection of immune checkpoint inhibitor-induced interstitial lung disease and associate with disease severity: a single-center retrospective study [0.03%]
以主观症状作为免疫检查点抑制剂相关间质性肺疾病的诱发因素并与疾病严重程度相关的单中心回顾性研究
Mari Yokoi,Atsushi Yonezawa,Daiki Hira et al.
Mari Yokoi et al.
Background: Interstitial lung disease (ILD) is one of the most common fatal immune-related adverse events (irAEs). ILD development adversely affects the continuation of anticancer drug therapy, including immune checkpoint...
Effect of blood pressure control on the risk of proteinuria during bevacizumab treatment in patients with colorectal cancer: a single-center retrospective cohort study [0.03%]
贝伐珠单抗治疗结直肠癌患者血压控制对蛋白尿风险影响的单中心回顾性队列研究
Satoru Nihei,Junichi Asaka,Mizunori Yaegashi et al.
Satoru Nihei et al.
Purpose: Pre-existing hypertension is reportedly a major risk factor for bevacizumab-induced proteinuria. However, few studies have focused on the effects of blood pressure (BP) control on proteinuria during bevacizumab t...
Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report [0.03%]
纳洛美丁诱发的阿片类药物所致便秘患者的乙状结肠憩室穿孔一例报告
Hayato Yokota,Yumiko Akamine,Mizuki Kobayashi et al.
Hayato Yokota et al.
Background: Naldemedine is an orally available peripherally acting μ-opioid receptor antagonist approved to treat opioid-induced constipation (OIC). It is contraindicated for patients with known or suspected gastrointest...
Fasudil hydrochloride and ozagrel sodium combination therapy for patients with aneurysmal subarachnoid hemorrhage: a cross-sectional study using a nationwide inpatient database [0.03%]
法舒地尔氯化氢和欧扎格雷钠联合治疗动脉瘤性蛛网膜下腔出血患者：一项基于全国住院病人数据库的横断面研究
Hiroshi Magara,Takuaki Tani,Shinobu Imai et al.
Hiroshi Magara et al.
Background: Fasudil and ozagrel are drugs with the same indications for the treatment of cerebral vasospasm in Japan. However, there have been no definitive conclusions on the clinical efficacy of fasudil hydrochloride an...
Characteristics of CYP3A4-related potential drug-drug interactions in outpatients receiving prescriptions from multiple clinical departments [0.03%]
多科处方门诊患者的CYP3A4相关潜在药物相互作用特征分析
Rina Matsuoka,Shinsuke Akagi,Tomohiro Konishi et al.
Rina Matsuoka et al.
Background: Drug-drug interactions (DDIs) increase the incidence of adverse drug reactions (ADRs). In a previous report, we revealed that the incidence of potential DDIs due to the same CYP molecular species in one prescr...
A retrospective study examining the association between polypharmacy and complications after laparoscopic surgery for colorectal cancer [0.03%]
一项回顾性研究：探讨结直肠癌腹腔镜手术后合并用药与并发症之间的关联
Takashi Watanabe,Shota Kashiwagura,Ryusuke Ouchi et al.
Takashi Watanabe et al.
Background: Polypharmacy is an escalating public health concern across various healthcare settings worldwide. We aimed to comprehensively investigate postoperative complications after laparoscopic surgery for colorectal c...
Hyperkalemic effect of drug-drug interaction between esaxerenone and trimethoprim in patients with hypertension: a pilot study [0.03%]
高血压患者中钾竞争性酸阻滞剂esseraxone与曲莫普利相互作用导致高钾血症的药代动力学和药效学研究：一项探索性研究
Toshinori Hirai,Shun Ueda,Toru Ogura et al.
Toshinori Hirai et al.
Background: We examined whether the pharmacodynamic drug-drug interaction between esaxerenone and trimethoprim enhances the hyperkalemic effect. Methods: ...