Successful desensitization to horse antithymocyte globulin for aplastic anemia: two case reports and literature review [0.03%]
马抗胸腺细胞球蛋白在再生障碍性贫血脱敏治疗成功的两例报告及文献复习
Satoshi Yuyama,Mitsuaki Oura,Tatsuya Isezaki et al.
Satoshi Yuyama et al.
Background: Horse antithymocyte globulin (hATG) is an important therapeutic option for aplastic anemia (AA). However, hATG carries the risk of fatal anaphylaxis, and skin tests are performed to identify high-risk patients...
Vancomycin dosing design method considering risk factors for nephrotoxicity [0.03%]
考虑肾毒性的危险因素的万古霉素给药设计方法
Yoshihiko Matsuki,Yutaro Kozima,Megumi Yanagi et al.
Yoshihiko Matsuki et al.
Background: Vancomycin (VCM) induces nephrotoxicity in a dose-dependent manner, and patients with risk factors for nephrotoxicity have been reported to develop nephrotoxicity even within the effective concentration range....
Factors affecting free vancomycin concentration and target attainment of free area under the concentration-time curve [0.03%]
影响游离万古霉素浓度及游离药物浓度-时间曲线下面积靶点达成的因素
Toshiharu Urakami,Yusuke Oka,Takashi Matono et al.
Toshiharu Urakami et al.
Background: It has been reported that the protein binding rate of vancomycin (VCM) varies among individual patients. So, the authors investigated relevant factors that may affect free VCM concentration and target attainme...
Impact of education on antibiotic literacy and awareness among pharmacy students at a Japanese university: a questionnaire survey [0.03%]
日本大学生的抗生素知识和认识水平及其影响因素：一项问卷调查研究
Masayuki Maeda,Kozue Yamaguchi
Masayuki Maeda
Background: Considering the global threat of antimicrobial resistance (AMR), Japan implemented a national action plan in 2016 that emphasized antibiotic education for healthcare professionals. However, pharmacy education ...
The utility of Glaucoma Information Cards for grasping glaucoma subtypes: a single-center pilot study [0.03%]
一项单中心试点研究：青光眼信息卡在把握青光眼亚型方面的作用
Yukinori Yamada,Tetsuya Murase,Emiko Mashida et al.
Yukinori Yamada et al.
Background: In Japan, anticholinergic drugs were contraindicated for glaucoma, regardless of subtype. The contraindication in patients with open-angle glaucoma (OAG) led to excessive medication restrictions because antich...
Investigation of the total anticholinergic load of reported anticholinergic drug-related adverse events using the Japanese adverse drug event report database: a retrospective pharmacovigilance study [0.03%]
利用日本药品不良事件报告数据库调查报道的抗胆碱药相关不良事件中的总抗胆碱负荷：一项回顾性药物警戒研究
Yusuke Kan,Maki Doi,Yoshihiro Uesawa
Yusuke Kan
Background: The Anticholinergic Risk Scale and Total Anticholinergic Load were developed to assess the risks associated with anticholinergic drugs. Recently, the Japan Anticholinergic Risk Scale was introduced; however, t...
Impact of discontinuation of cephazolin prophylaxis on the incidence of postoperative adverse events in cataract surgery [0.03%]
左旋卡尼丁对眼科超声乳化白内障手术预防性使用头孢唑林停药后术后不良事件发生率的影响研究
Kazutaka Uchida,Keita Takahama,Kenshiro Higashi et al.
Kazutaka Uchida et al.
Background: Cataract surgeries are increasing annually, making appropriate medical management essential. The routine use of systemic antimicrobial agents for preventing surgical site infections lacks strong evidence and m...
Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy [0.03%]
医院药事委员会对抗碳青霉烯类药物使用的影响：分段时间序列分析及倾向匹配的非劣效性研究
Nakaba Okamura,Ayano Katagiri,Tomoya Komori et al.
Nakaba Okamura et al.
Background: Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost efficiency. Although formulary implementation has been increasing in Japan, comprehensive e...
Toxic epidermal necrolysis with thrombocytopenia induced by intravenous immunoglobulin: a case report and mini review [0.03%]
静脉注射免疫球蛋白诱发的中毒性表皮坏死松解症合并血小板减少1例及文献复习
Yoshihiro Nishita,Masatoshi Taga,Nozomi Arakawa et al.
Yoshihiro Nishita et al.
Background: Toxic epidermal necrolysis (TEN), a severe cutaneous hypersensitivity reaction induced particularly by drugs, is diagnosed when there is a fever of ≥ 38 °C, mucocutaneous symptoms, a rash with multiple eryth...
Remdesivir-induced severe hypoglycemia in an elderly man without diabetes: a case report [0.03%]
瑞德西韦致无糖尿病老人严重低血糖一例报告
Yasunori Nagano,Hisae Aoki,Juri David et al.
Yasunori Nagano et al.
Background: Remdesivir is recommended to treat hospitalized patients with coronavirus disease 2019 (COVID-19). Remdesivir is known to affect glucose metabolism in individuals with and without diabetes. However, little is ...