Xenopax for the treatment of steroid-refractory acute graft-versus-host disease: the RELAX study [0.03%]
XENOPAX治疗糖皮质激素难治性急性移植物抗宿主病的RELAX研究
Le-Qing Cao,Wen-Xuan Huo,Er-Lie Jiang et al.
Le-Qing Cao et al.
Background: Steroid-refractory (SR) acute graft-versus-host disease (aGVHD) is the major cause of early mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Xenopax, a novel and the only availab...
Multicenter Study
Military Medical Research. 2025 Sep 29;12(1):63. DOI:10.1186/s40779-025-00640-0 2025
Are metformin-based combination approaches beneficial for non-small cell lung cancer: evidence from experimental and clinical studies [0.03%]
二甲双胍为基础的联合疗法对非小细胞肺癌有效吗？来自实验和临床研究的证据
Anita Thyagarajan,Vaibhav Gajjar,Ravi P Sahu
Anita Thyagarajan
Despite having multiple treatment options, the overall outcomes, including the survival rates of non-small cell lung cancer (NSCLC) patients, remain relatively low, indicating the need to explore new approaches to achieve improved therapeut...
Dual character of surface engineering on SN38 prodrug nano-assemblies: divergent effects on in vitro and in vivo behavior [0.03%]
SN38前药纳米组装体表面工程的双重特性：对体外和体内行为的不同影响
Ya-Qiao Li,Zhi-Yu Kuang,Bao-Yuan Zhang et al.
Ya-Qiao Li et al.
Background: Surface engineering has emerged as a promising strategy to enhance the performance of nanomedicines. In particular, the PEGylation levels for chemotherapy drug 7-Ethyl-10-hydroxycamptothecin (SN38) prodrug nan...
Camouflaged membrane-bridged radionuclide/Mn single-atom enzymes target lipid metabolism disruption to evoke antitumor immunity [0.03%]
迷彩膜桥式核素/锰单原子酶抗脂质代谢紊乱以激发肿瘤免疫效应
Meng-Die Yang,Chun-Yan Zhu,Gang Yang et al.
Meng-Die Yang et al.
Background: Lipid metabolic reprogramming has been increasingly recognized as a key factor contributing to tumor immune evasion, therapeutic resistance, and plasticity, which collectively compromise the efficacy of target...
ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases [0.03%]
ALDH2在自噬和细胞死亡中的作用：分子机制及其对疾病的影响
Yu Duan,Ze-Chen Shan,Jiao-Jiao Pang et al.
Yu Duan et al.
Aldehyde dehydrogenase (ALDH) 2, a mitochondrial enzyme, is the main acetaldehyde dehydrogenase involved in the scavenging of alcohol-derived acetaldehyde and endogenous aldehydes. The ALDH2rs671 mutation affects 560 million East Asians and...
Evaluation and application of an innovative portable field endoscope: addressing battlefield and biosafety concerns [0.03%]
一种创新便携式现场内窥镜的评估与应用：解决战场和生物安全问题
Gang Sun,Jia-Qi Zeng,Jun-Ling Wu et al.
Gang Sun et al.
Background: At present, no commercially available endoscopic system is specifically designed for use in the battlefield, disaster relief, or unique environments with biosafety concerns. Therefore, this limitation stems fr...
Global patterns and trends in cancer-related premature death and their impact on life expectancy across 185 countries: a population-based analysis [0.03%]
全球癌症所致过早死亡的分布及变化趋势及其对185个国家期望寿命的影响：基于人口的分析研究
Ke-Xin Sun,Xin Liang,Qian Zhu et al.
Ke-Xin Sun et al.
Background: The level of premature deaths (deaths among those aged 30-69 years) caused by cancer is an important indicator of evaluating the level of cancer prevention and control. However, the current burden and temporal...
Diana Julia Tedesco,Maria Fernanda Hutter,Fadi Khalaf et al.
Diana Julia Tedesco et al.
Background: Although sepsis is known to be the leading cause of morbidity and mortality in adult burn patients, its epidemiology and impact are poorly understood. This study aims to address these gaps by further character...
Clinical-transcriptomic classification of lumbar disc degeneration enhanced by machine learning [0.03%]
基于机器学习的临床转录组学分类法在腰椎间盘病变中的应用
Huai-Jian Jin,Peng Lin,Xiao-Yuan Ma et al.
Huai-Jian Jin et al.
Background: Lumbar disc degeneration (LDD) displays considerable heterogeneity in terms of clinical features and pathological changes. However, researchers have not clearly determined whether the transcriptome variations ...